The Search for Antiviral Drugs: Case Histories from Concept to Clinic

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Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut. Text on the development of drugs used to treat HIV, rhinoviruses, and herpes simplex virus. For researchers or practitioners in pharmacology, virology, and related areas. Illustrated. 14 contributors, 8 U.S.
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1993 Hard cover New. Sewn binding. Cloth over boards. 240 p. Contains: Illustrations. Audience: General/trade. BRAND NEW. NO DJ. (as issued)

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1993 Hard cover Illustrated. New in New dust jacket. Sewn binding. Cloth over boards. 240 p. Contains: Illustrations.

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Overview

Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut. Text on the development of drugs used to treat HIV, rhinoviruses, and herpes simplex virus. For researchers or practitioners in pharmacology, virology, and related areas. Illustrated. 14 contributors, 8 U.S.
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Editorial Reviews

Booknews
Researchers from pharmaceutical laboratories throughout the world provide ten personal, behind-the-scenes accounts of large-scale antiviral projects ranging from the early production of the nucleoside analogs for the effective treatment of viral infections to the current search for effective and profitable drugs to combat HIV, Herpes, and the common cold. Assumes a fairly high degree of sophistication in chemistry. No index. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780817636067
  • Publisher: Birkhauser Verlag
  • Publication date: 6/1/1993
  • Pages: 240

Table of Contents

Preface
Contributors
1 Introduction: The First Effective Antiviral 1
2 Discovery and Development of Zidovudine as the Cornerstone of Therapy to Control Human Immunodeficiency Virus Infection 23
3 Discovery of Nevirapine, a Nonnucleoside Inhibitor of HW-1 Reverse Transcriptase 45
4 Discovery of TIBO, a New Family of HIV-1-Specific Reverse Transcriptase Inhibitors 71
5 Discovery and Development of 2-Pyridinone HIV-1 Reverse Transcriptase Inhibitors 105
6 Discovery and Development of the HIV Proteinase Inhibitor Ro 31-8959 129
7 A New Approach to Antiviral Chemotherapy: Intervention in Viral Gene Expression by HIV Tat Antagonists 153
8 Discovery of Pirodavir, a Broad-Spectrum Inhibitor of Rhinoviruses 179
9 sICAM-1 as a Receptor Antagonist for Rhinoviruses: A Model System of Adhesion Molecule as Cell Receptors for Viruses 211
10 Inactivation of Herpes Simplex Virus Ribonucleotide Reductase by Subunit Association Inhibitors: A Potential Antiviral Strategy 225
Keyword Index 239
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