Timely, levelheaded investigation of stem-cell medicine. Stem cells possess the power to regenerate and repair body tissue, Furcht and Hoffman (both: Laboratory Medicine and Pathology/Univ. of Minnesota Medical School) remind us. Some of that power has been tapped, for instance, in countering bone-marrow failure. But stem cells' theoretical potential to regenerate and restore all of the body's tissues, particularly via embryonic stem cells, will be fully realized, if ever, only after extensive research. Nothing is starry-eyed in this plainspoken, well-tuned text. Although researchers are unveiling the mystery of stem cells everyday, and much lies in the province of possibility, the authors aver that those possibilities are based on good science, which they capably explicate for the reader. Their treatment of the stem-cell issue is thoroughgoing, acknowledging that embryonic stem-cell research raises bioethical as well as biological questions, and that economic considerations play a role in its development. They treat the ethical issue with respect, applying a cross-cultural perspective to everything from designer babies to the commodification of life. They make a case for continued research with some intelligent form of governance: "Ethical lines move all the time within the polity, subject to the dynamics of the polity-that is, politics." The denial of federal funds, they fear, will contribute to the brain drain of researchers from the United States, despite infusions of state, philanthropic and venture capital. They also warn of the technology's dual use: "To understand the immune system enough to re-create it is to possess the potential biological power of annihilation"-a threat onlyknowledge can check. Noting that the biorevolution gives humankind a potentially vast power to expand the boundaries of life, the authors ask, "Are we . . . prepared to understand that power, seize it, and use it wisely?" Their cogent survey gives readers the tools to address that daunting question. First printing of 20,000
Leo Furcht, MD, is Allan-Pardee professor and chairman of the Department of Laboratory Medicine and Pathology at the University of Minnesota Medical School. A former president of the Federation of American Societies of Experimental Biology, he holds several key patents in the stem cell field. He lives in Minneapolis, Minnesota.
William Hoffman has been a writer and editor in the University of Minnesota Medical School for over twenty-five years and has created a series of Web-based global bioscience maps that show how competition in science and business affects ethics, policymaking, and economic development. He lives in Minneapolis, Minnesota.
Brock Reeve is executive director of the Harvard Stem Cell Institute and the brother of the late Christopher Reeve. He lives in Boston, Massachusetts.
Foreword Brock Reeve xi
Prologue: Into the Cave lvii
Agents of Hope 1
Diseases and Cancers of the Blood
Diabetes and Other Autoimmune Diseases
Spinal Cord Injury and Nervous System Diseases
Universal Donor Cells
Architects of Development 35
Stem Cells 101
A Brief History of Regenerative Science
Closing the "Regeneration Gap"
The Genetics of Stem Cells
Cellular Aging and Immortality
Gastrulation and a Womb with a View
The Future of Regeneration
Challengers of Ethics 75
Using Surplus Embryos
Life and Death on the Moral Compass
Barometers of Politics 115
Public Opinion and Corn-Pone Politics
Cloning and the United Nations
Stem Cells and the Law
Are Humans Patentable?
Objects of Competition 145
Is America Losing Its Edge?
Clusters of Innovation
Patient Advocacy Goes Global
Free Exchange of Stem Cell Know-How
Harbingers of Destruction 195
Immunity in the Age of Bioterrorism
Military Research and Development
A Matter of National Security
An Immune System in aBottle
The Future of Immunity
Theoretical Possibilities of Death
Controlling the Power of Stem Cells
Epilogue: Beyond the Darkness 233