If any disease can be said to epitomize and era, peptic ulcer does so for our time.Virtually unknown before 1900, cases of ulcers have reached epidemic proportions in the twentieth century. Up until the 1970s this painful disease was difficult to treat, often requiring surgery and leading to disability and even death. Since then, a bewildering succession of drug treatments has appeared and care is now possible. The Ulcer Story is the first and only book to make sense of the flood of new information for the general reader, and there is much here that will interest and challenge doctors as well.While revealing the plots and subplots of the history of peptic ulcers, Dr. Thompson shows us the paths we can take to regain a healthy and pain-free existence. Throughout, he brings to bear his impressive credentials and years of clinical experience to equip us with the means to assess our own conditions and treatments. Drawing upon cutting-edge research and the successful strategies of talented clinicians, he answers our most urgent questions: How do doctors diagnose ulcers and distinguish them from other gut ailments? What drugs are safe and effective and how do they work? What lifestyle changes, if any, can we make to control or even eliminate symptoms of dyspepsia and heatburn? Will the future bring a complete cure for the many types of ulcers?Most of the many heroes of this story are the working physicians who fight this once debilitating disease, and who have translated medical innovation into life-saving treatment. Dedicated to them, and to the legions of ulcer and heatburn sufferers for whom there is now hope, The Ulcer Story is an inspiration.
"...sorts through the plethora of treatments and preventive information available...explains how doctors diagnose ulcers, effective and safe drug treatments, and how lifestyle changes can control ulcers and dyspepsia."
| Ch. 1 | The Gut: A Brief Anatomy | 3 |
| Ch. 2 | Physiology: How the Gut Works | 19 |
| Ch. 3 | Terminology | 27 |
| Ch. 4 | The Peptic Ulcer Story: A Brief History | 33 |
| Ch. 5 | Epidemiology of Ulcers, Dyspepsia, and Heartburn | 59 |
| Ch. 6 | Gastric Secretion | 71 |
| Ch. 7 | NSAIDs: Nonsteroidal Anti-Inflammatory Drugs | 81 |
| Ch. 8 | Helicobacter pylori | 93 |
| Ch. 9 | Other Causes: Genetics, Lifestyle, and Stress | 105 |
| Ch. 10 | Dyspepsia | 115 |
| Ch. 11 | Peptic Ulcer: Gastric and Duodenal | 129 |
| Ch. 12 | Rare and Atypical Ulcers | 141 |
| Ch. 13 | Complications of Peptic Ulcer | 153 |
| Ch. 14 | Gastroesophageal Reflux | 171 |
| Ch. 15 | Heartburn and Esophagitis | 183 |
| Ch. 16 | Diagnosis and Treatment of Heartburn and Esophagitis | 191 |
| Ch. 17 | Complications of Gastroesophageal Reflux | 203 |
| Ch. 18 | Functional Dyspepsia: Non-Ulcer Dyspepsia | 223 |
| Ch. 19 | Noncardiac Chest Pain: The Irritable Esophagus | 233 |
| Ch. 20 | Burbulence: Functional Abdominal Bloating | 241 |
| Ch. 21 | Cancer of the Upper Gut | 251 |
| Ch. 22 | Antacids | 259 |
| Ch. 23 | Histamine H[subscript 2] Antagonists | 269 |
| Ch. 24 | Proton Pump Inhibitors | 279 |
| Ch. 25 | Sucralfate | 285 |
| Ch. 26 | Prostaglandins | 289 |
| Ch. 27 | Bismuth and Antibiotics: Treatment of H. pylori | 293 |
| Ch. 28 | The Prokinetics: Gastrokinetics | 309 |
| Ch. 29 | Ulcer and Antireflux Surgery: Postsurgical Problems | 315 |
| Ch. 30 | Testing Treatments: Clinical Trials and Placebos | 337 |
| Ch. 31 | Investigations: Testing Upper Gut Symptoms | 349 |
| Epilogue | 359 | |
| Bibliography | 365 | |
| Index | 387 |
Overview
If any disease can be said to epitomize and era, peptic ulcer does so for our time.Virtually unknown before 1900, cases of ulcers have reached epidemic proportions in the twentieth century. Up until the 1970s this painful disease was difficult to treat, often requiring surgery and leading to disability and even death. Since then, a bewildering succession of drug treatments has appeared and care is now possible. The Ulcer Story is the first and only book to make sense of the flood of new information for the ...