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The World of Nano-Biomechanics: Mechanical Imaging and Measurement by Atomic Force Microscopy

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Mechanics in biology at the nanometer scaled world is an exciting recent development where biology meets physics and engineering.

Surrounded by the thermal agitation of solvent molecules, proteins, DNAs, polysaccharides, lipid membranes, and the functional structures based on their interactions must keep their integrity as information processing machineries for their biological functions. The requirement for their mechanical rigidity and flexibility for this purpose is now being studied at the single molecular level using the state-of-the-art technologies of recent development.

This book introduces elementary mechanics necessary to understand the biology at the nano-world. Breathtaking experiments such as single molecule stretching of DNA, RNA and proteins are now revealing the internal mechanics of their molecular structure. Just looking into the response of protein molecules against the tensile stretching exposing their interior under the physiological conditions is phenomenal.

Written by an author with biochemical and biophysical background, this book is an ideal guidance to bio-nanomechanics for those who are not familiar with mechanical concepts.

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Product Details

  • ISBN-13: 9780444527776
  • Publisher: Elsevier Science
  • Publication date: 12/5/2007
  • Pages: 300
  • Product dimensions: 6.10 (w) x 9.10 (h) x 0.80 (d)

Meet the Author

Graduated from the University of Tokyo (B.S. in Biophysics and Biochemistry, 1965) and obtained Ph.D. from Duke University (Physical Biochemistry, 1971). Worked in protein denaturation and renaturation under Dr. Charles Tanford and then returned to Univ. of Tokyo to continue the work on protein science. Appointed Professor of Biodynamics at Tokyo Institute of Technology in 1989.

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Table of Contents

Chapter 1. Force in Biology
Chapter 2. Introduction to Basic Mechanics
Chapter 3. Force and Force Measurement Apparatuses
Chapter 4. Polymer Chain Mechanics
Chapter 5. Interaction Forces
Chapter 6. Single Molecule Interaction Forces
Chapter 7. Single Molecule DNA and RNA Mechanics
Chapter 8. Single Molecule Protein Mechanics
Chapter 9. Motion in Nano-biology
Chapter 10. Cell Mechanics
Chapter 11. Manipulation at the Molecular Level
Chapter 12. Finite Element Analysis of Microscopic Biological Structures
Chapter 13. Appendices

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