Thiamine Deficiency and Associated Clinical Disorders / Edition 1

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The past twenty years have seen remarkable advances in neuroscience, neurology, imaging techniques, and diagnostic strategies. These advances have been successfully applied to many different diseases , including thiamine deficiency and associated clinical disorders. Syndromes such as beriberi, Wernicke's disease, Leigh's disease, African Seasonal Ataxia, and various inherited ataxias, have all benefited from improved scientific approaches. Thiamine Deficiency and Associated Clinical Disorders represents an intriging area of both basic and clinical investigation. Modern imaging and diagnostic strategies have facilitated the rapid treatment, and potential reversal of these clinical disorders. The fusion of laboratory and clinical knowledge serve as an example of how research can translate to successful treatment. This book is designed to bring together cogent results from both basic and clinical investigation. These data will be of interest to neurologists, internists, nutritionists, biochemists, neurochemists, neuroscientists, and many others with interest in thiamine deficiency.

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Editorial Reviews

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“This short 192 page book Thiamine Deficiency and Associated Clinical Disorders, which is part of the ongoing Contemporary Clinical Neuroscience series, is authored by David McCandless, Ph.D. who is known for his work in metabolic encephalopathy. For those who wish to have a deeper understanding of a number of metabolic derangements which result in neurological dysfunction, this book would be of interest. For the neuroradiologist there is an opportunity to view gross pathology and histopathology … .” (American Journal of Neuroradiology, October, 2009)

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Product Details

  • ISBN-13: 9781607613107
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 8/21/2009
  • Series: Contemporary Clinical Neuroscience Series
  • Edition description: 2009
  • Edition number: 1
  • Pages: 192
  • Product dimensions: 6.20 (w) x 9.40 (h) x 0.70 (d)

Table of Contents

Early Chemistry 1

Early Thiamine Deficiency 9

Thiamine Deficiency in Mammals 17

Beriberi 31

Wernicke's Disease 47

Central Pontine Myelinolysis, Alcoholic Cerebellar Degeneration, and Marchiafava-Bignami Disease 65

Central Pontine Myelinolysis 65

Alcoholic Cerebellar Degeneration 72

Marchiafava-Bignami Disease 75

Leigh's Disease 81

African Seasonal Ataxia 103

Inherited Ataxias 113

Thiamine Deficiency in Serious Blness 131

Beriberi 131

Cancer 132

Intensive Care Units 133

Hematologic Tumors 134

Gastrectomy 134

5-Fluorouracil 136

Wernicke's Disease and Gastrectomy 139


Malaria 141

Amyotrophic Lateral Sclerosis 142

Alzheimer's Disease 143

World Health Concerns 145

Epilogue: Future Prospects 151

Animal Models of Thiamine Deficiency 151

Beriberi 153

Wernicke's Disease 154


Leigh's Disease 157

Inherited Ataxias 158

Serious Illnesses and Thiamine Deficiency 159

Conclusions 160

Appendix A Bontius Translation 161

Appendix B Thiamine Synonyms 163

Appendix C The Nobel Prize Acceptance Speech of Dr. Christiaan Eijkman, 1929 165

References 173

Index 185

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