Thomas' Hematopoietic Cell Transplantation

Thomas' Hematopoietic Cell Transplantation

by Karl G. Blume

An Essential resource for all hematologists, oncologists, pathologists, pediatricians, immunologists and all others interested in this dynamic area of medicine!

Why you should buy this book....

  • Extensive coverage of subject area - from the scientific basis to the view of the future
  • Includes all experimental research and clinical

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An Essential resource for all hematologists, oncologists, pathologists, pediatricians, immunologists and all others interested in this dynamic area of medicine!

Why you should buy this book....

  • Extensive coverage of subject area - from the scientific basis to the view of the future
  • Includes all experimental research and clinical application
  • Combined the knowledge and expertise of over 170 international specialists
  • Clear structure and layout
  • Over 500 illustrations, including a colour plate section

Why buy the NEW edition......

  • New and fully revised to reflect the latest developments in this fast moving field
  • 10 new chapters, covering some of the latest developments - see below for the complete tables of content

Haematopoietic cell transplantation is the intravenous infusion of haematopoietic progenitor cells designed to establish marrow and immune function in patients with a variety of acquired and inherited malignant and non-malignant disorders. These include hematological malignancies (leukaemia, lymphoma and myeloma), non-malignant acquired bone marrow disorders (aplastic anaemia), and genetic diseases associated with abnormal haematopoiesis and function (thalassaemia, sickle cell anaemia, and severe combined immunodeficiency). Haematopoietic cell transplantation is also key in the support of patients undergoing high-dose chemotherapy for the treatment of malignant diseases for which hematological toxicity would otherwise limit drug administration (e.g. breast, germ-cell and ovarian cancers).

This is an outstanding reference source on bone marrow transplantation which has become recognised as the bible in the field. The original editor, Donnall Thomas, was a pioneer in the field and won the 1990 Nobel Prize for his discoveries concerning organ and cell transplantation in the treatment of human diseases.

During the past three decades there has been outstanding progress in the area which has led to an exponential increase in the number of transplant recipients worldwide. More than 13,000 new cases of haematopoietic stem cell transplantation per year have been recently reported to the International Bone Marrow Transplant Registry. This considerable increase in number has been paralleled by impressive basic and applied research into the uses of hematopoietic stem cell transplantation. There is therefore now a need for a new edition of Hematopoietic Stem Cell Transplantation to accumulate this knowledge and convey the most current information available.

The third edition will be divided into eight sections containing over 100 chapters written by international experts in the field of blood and bone marrow transplantation. The text will be completely revised and updated throughout to take account of new and recent developments, from both a scientific and clinical perspective. There are ten completely new chapters.

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Editorial Reviews

Doody's Review Service
Reviewer: Jayesh Mehta, MD (Northwestern University Feinberg School of Medicine)
Description: This is the third edition of the most comprehensive and complete textbook of hematopoietic stem cell transplantation (HSCT) available. The second edition was published in 1999.
Purpose: The breadth of knowledge in the field of HSCT has increased significantly over the last five years. The purpose is to thoroughly revise the previous edition so that this information is documented and critically evaluated. These are important objectives that ensure the book's relevance. The addition of several new chapters along with revamping of other chapters has made the book complete, comprehensive, and reasonably current, and has fulfilled the editors' stated objectives.
Audience: The book is primarily targeted at physicians and scientists working in the field of HSCT. Trainees in the field as well as physicians from other specialties who interact with transplant physicians are also likely to find relevant chapters useful as a reference source. Its sheer size and depth precludes it from being used as a book one could sit down with and read from cover to cover to get an idea of HSCT. There have been miniguides in the past which have enabled this, and these may still be the primary source of knowledge to those who are not directly working in the field. The editors credible authorities who are world renowned. Most contributors are also well known in the field.
Features: The book covers every conceivable topic related to HSCT such as hematopoietic stem cells and their biology, pharmacology of high-dose therapy, complications and their management, and clinical results. Additional chapters on history, statistics, transplant registries, regulatory issues, nursing aspects, ethics, and patient issues such as quality of life add up to a total of 110 chapters. All chapters are informative and some are excellent. Of particular note is the one on gastrointestinal and hepatic complications by Strasser and McDonald. At 42 pages, over 700 references, and several practically useful flow charts, it is the most outstanding account of this complex subject I have seen. There is significant redundancy in some of the chapters covering clinical results for specific diseases where much space and a very large number of references have been devoted to a description of the underlying disease itself — something that probably has no place in a specialized textbook. It is also debatable whether in utero transplantation merits a chapter of its own. Do "Histocompatibility" and "Functional evolution of the major histocompatibility complex" need to be separate chapters? However, these are minor concerns that do not detract from the utility of the book.
Assessment: Overall, the book is excellent and offers a breadth and depth of knowledge of the field that only one other book can match. The noteworthy competitor is Clinical Bone Marrow and Blood Stem Cell Transplantation by Atkinson, et al. (Cambridge University Press, 2004). The Atkinson work has a considerably more international perspective whereas the Thomas book is almost completely limited to North America. The first two editions of the Atkinson work were smaller — and therefore friendlier. The third editions of both books are equally lengthy. This edition is sufficiently different from the previous one because of evolution of the field and comprehensive coverage of the changes to justify replacing the second edition.
From the Publisher
"A must for the bookshelf of any person who has even the vaguest interest in the biology or practice of marrow, blood, or umbilical-cord hematopoietic stem-cell transplantation."

New England Journal of Medicine

"Essential addition to the library of any unit performing bone marrow transplants."

Journal of Hematotherapy

"Uniformly informative, helpful, well-organised and presented, comprehensive, up-to-date and well-referenced."

British Journal of Haematology

"Overwhelmingly complete, extremely up-to-date and each chapter is written by a world leader in the field."

Clinical and Laboratory Haematology

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Product Details

Publication date:
Edition description:
Third Edition
Product dimensions:
8.90(w) x 11.10(h) x 2.49(d)

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