Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Preclinical, and Clinical Biology / Edition 1

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Overview

David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of this new hormone. Along the way they provide the most recent and comprehensive guide to the biology of megakaryocytes and platelets.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Booknews
A summary of current research and literature regarding thrombopoietins (TPO) whose recent discovery two years ago has prompted a flurry of trials and studies. The 23 contributing researchers review the history of the search to discover TPO, describe the molecular and biological characteristics of the new molecule, and present the results of the preclinical animal experiments that will guide the clinical use of the hormone while also providing a comprehensive guide to the biology of megakaryocytes and platelets. Contains reproducible protocols to study TPO, photographs, charts, and graphs. Annotation c. by Book News, Inc., Portland, Or.
From the Publisher
...a useful reference tool for oncologists, hemtologists, physicians, and medical researchers. -Biological Abstracts/RRM
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Product Details

  • ISBN-13: 9780896033795
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/1/1996
  • Edition description: 1997
  • Edition number: 1
  • Pages: 413
  • Product dimensions: 7.20 (w) x 10.20 (h) x 0.90 (d)

Table of Contents

Foreword
Preface
List of Contributors
1 Megakaryocyte Biology 3
2 Platelet Structure and Function 41
3 The Evolution of Mammalian Platelets 63
4 Potential Clinical Applications of Thrombopoietic Growth Factors 79
5 Historical Perspective and Overview 95
6 The Murine Myeloproliferative Leukemia Virus MPLV, v-mpl Oncogene, and c-mpl 109
7 Mpl Expression and Functional Role in Human Megakaryocytopoiesis 123
8 The Purification and Cloning of Human Thrombopoietin 135
9 The Purification of Thrombopoietin from Thrombocytopenic Plasma 143
10 The Role of Other Hemopoietic Growth Factors and the Marrow Microenvironment in Megakaryocytopoiesis 165
11 Structure of Thrombopoietin and the Thrombopoietin Gene 181
12 Transcription Factors in Megakaryocyte Differentiation and Gene Expression 189
13 The Biological Significance of Truncated and Full-Length Forms of Mpl Ligands 203
14 In Vitro Effects of Mpl Ligand on Human Hemopoietic Progenitor Cells 217
15 Effect of Cytokines on the Development of Megakaryocytes and Platelets: As Ultrastructural Analysis 237
16 The Thrombopoietin Receptor, Mpl, and Signal Transduction 257
17 Regulation of Proplatelet and Platelet Formation In Vitro 271
18 In Vitro Effects of Mpl Ligands on Platelet Function 285
19 In Vivo Dose - Response Effects of Mpl Ligands on Platelet Production and Function 301
20 Efficacy of Mpl Ligands and other Thrombopoietic Cytokines in Animal Models 321
21 Genetic Manipulation of Mpl Ligand and Thrombopoietin In Vivo 349
22 Serum Levels of Thrombopoietin in Health and Disease 359
23 The Regulation of Platelet Production In Vivo 377
Glossary 397
Index 401
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