Thrombopoiesis and Thrombopoietins: Molecular, Cellular, Preclinical, and Clinical Biology

Overview

David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of flits new hormone. Along the way they provide the most recent and comprehensive guide to the ...
See more details below
Available through our Marketplace sellers.
Other sellers (Paperback)
  • All (2) from $136.59   
  • New (1) from $136.59   
  • Used (1) from $227.35   
Close
Sort by
Page 1 of 1
Showing All
Note: Marketplace items are not eligible for any BN.com coupons and promotions
$136.59
Seller since 2007

Feedback rating:

(23706)

Condition:

New — never opened or used in original packaging.

Like New — packaging may have been opened. A "Like New" item is suitable to give as a gift.

Very Good — may have minor signs of wear on packaging but item works perfectly and has no damage.

Good — item is in good condition but packaging may have signs of shelf wear/aging or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Acceptable — item is in working order but may show signs of wear such as scratches or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Used — An item that has been opened and may show signs of wear. All specific defects should be noted in the Comments section associated with each item.

Refurbished — A used item that has been renewed or updated and verified to be in proper working condition. Not necessarily completed by the original manufacturer.

New
BRAND NEW

Ships from: Avenel, NJ

Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
Page 1 of 1
Showing All
Close
Sort by
Sending request ...

Overview

David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of flits new hormone. Along the way they provide the most recent and comprehensive guide to the biology of megakaryocytes and platelets.

The book contains predominantly black-and-white illustrations, with some color illustrations.

Read More Show Less

Editorial Reviews

From the Publisher
...a useful reference tool for oncologists, hemtologists, physicians, and medical researchers. -Biological Abstracts/RRM
Read More Show Less

Product Details

  • ISBN-13: 9781461284406
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 7/31/2012
  • Edition description: Softcover reprint of the original 1st ed. 1997
  • Edition number: 1
  • Pages: 412

Table of Contents

Foreword, Shirley Ebbe. Part I: Introduction. Megakaryocyte Biology, Carl W. Jackson, Julie T. Arnold, Tamara I. Pestina, and Paula E. Stenberg. Platelet Structure and Function, Dorothea Zucker-Franklin. The Evolution of Mammalian Platelets, Jack Levin. Potential Clinical Applications of Thrombopoietic Growth Factors, Charles A. Schiffer. Part II: The Search for the Physiologic Regulator of Platelet Production. Historical Perspective and Overview, Eric M. Mazur. The Murine Myeloproliferative Leukemia Virus MPLV, v-mpl Oncogene, and c-mpl, Françoise Wendling and Sylvie Gisselbrecht. Mpl Expression and Functional Role in Human Megakaryocytopoiesis, Françoise Wendling, Najet Debili, and William Vainchenker. The Purification and Cloning of Human Thrombopoietin, Dan Eaton. The Purification of Thrombopoietin from Thrombocytopenic Plasma, David J. Kuter, Hiroshi Miyazaki, and Takashi Kato. The Role of Other Hemopoietic Growth Factors and the Marrow Microenvironment in Megakaryocytopoiesis, Ronald Hoffman. Part III: Molecular Biology. Structure of Thrombopoietin and the Thrombopoietin Gene, Austin L. Gurney and Frederic J. de Sauvage. Transcription Factors in Megakaryocyte Differentiation and Gene Expression, Ramesh A. Shivdasani. The Biological Significance of Truncated and Full-Length Forms of Mpl Ligands, Donald Foster and Pamela Hunt. Part IV: Cellular Biology. In Vitro Effects of Mpl Ligand on Human Hemopoietic Progenitor Cells, Najet Debili, Elisabeth Cramer, Françoise Wendling, and William Vainchenker. Effect of Cytokines on the Development of Megakaryocytes and Platelets: An Ultrastructural Analysis, Dorothea Zucker-Franklin. The Thrombopoietin Receptor, Mpl, and Signal Transduction, Kenneth Kaushansky, Virginia C. Broudy, and Jonathan G. Drachman. Regulation of Proplatelet and Platelet Formation In Vitro, Esther Choi. In Vitro Effects of Mpl Ligands on Platelet Function, Laurence A. Harker, Ulla M. Marzec, and Christopher F. Toombs. Part V: Preclinical Biology.In Vivo Dose-Response Effects of Mpl Ligands and Platelet Production and Function, Laurence A. Harker, Christopher F. Toombs, and Richard B. Stead. Efficacy of Mpl Ligands and other Thrombopoietic Cytokines in Animal Models, Ann M. Farese and Thomas J. MacVittie. Genetic Manipulation of Mpl Ligand and Thrombopoietin In Vivo, Frederic J. de Sauvage and Mark W. Moore. Part VI: Clinical Biology. Serum Levels of Thrombopoietin in Health and Disease, Janet Lee Nichol. The Regulation of Platelet Production In Vivo, David J. Kuter. Glossary. Index.
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)