Tissue-Specific vascular endothelial signals and vector targeting, Part B

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The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

• Includes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, providing researchers an overview and synthesis of the latest findings in the area
• Presents up-to-date research from leaders in the field

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Editorial Reviews

From the Publisher
Praise for Advances in Genetics: "Outstanding both in variety and in the quality of its contributions."—NATURE "Can be highly recommended to geneticists, and biologists in general...will prove to be of high importance for the development of the science of genetics."—SCIENCE
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Product Details

  • ISBN-13: 9780123750228
  • Publisher: Elsevier Science
  • Publication date: 9/27/2010
  • Pages: 174
  • Product dimensions: 6.00 (w) x 9.10 (h) x 0.60 (d)

Table of Contents

Contributors ix

1 MR Molecular Imaging of Tumor Vasculature and Vascular Targets Arvind P. Pathak Marie-France Penet Zaver M. Bhujwalla 1

I Introduction 2

II Structural, Functional, and Molecular Characteristics of Tumor Vasculature 3

III Basis of Contrast in MR Images 7

IV Imaging Receptor Expression 16

V Imaging Vascular Targeting 17

VI Multimodal Molecular-Functional Imaging of Tumor Vasculature 19

VII Conclusion 21

References 22

2 An Integrated Approach for the Rational Design of Nanovectors for Biomedical Imaging and Therapy Biana Godin Wouter H. P. Driessen Bettina Proneth Sei-Young Lee Srimeenakshi Srinivasan Rolando Rumbaut Wadih Arap Renata Pasqualini Mauro Ferrari Paolo Decuzzi 31

I Introduction 32

II Three Generations of Nanovectors 34

III Mathematical Models for Predicting the Nanovectors' Behavior 39

IV Biophysical Characterization of Nanovectors 48

V Vascular Targeting Moieties 50

VI In vitro Assays for Nanovectors' Characterization 53

VII Intravital Video Microscopy 55

VIII Conclusions 57

References 59

3 Targeted Systemic Gene Therapy and Molecular Imaging of Cancer: Contribution of the Vascular-Targeted AAVP Vector Amin Hajitou 65

I Introduction 66

II Targeted Gene Delivery 68

III Conclusions and Perspectives 79

References 80

4 Cationic and Tissue-Specific Protein Transduction Domains: Identification, Characterization, and Therapeutic Application Maliha Zahid Xiaoli Lu Zhibao Mi Paul D. Robbins 83

I Introduction 84

II Cationic Protein Transduction Domains 84

III Biopanning using Peptide Phage Display Libraries 85

IV Peptide Phage Display Biopanning in Cell Culture for Transduction Peptides 87

V Methods for Analysis of Transduction Efficiency 90

VI Peptide Phage Display Biopanning in vivo for Transduction Peptides 91

VII PTDs as Therapeutics 92

VIII Conclusions 93

References 93

5 GRP78 Signaling Hub: A Receptor for Targeted Tumor Therapy Masanori Sato Virginia J. Yao Wadih Arap Renata Pasqualini 97

I Introduction 99

II GRP78 Association with Activated α2-Macroglobulin Promotes Cell Proliferation 101

III GRP78 Autoantibody Predicts Poor Prognosis in Tumors but Shows Therapeutic Effects in Rheumatoid Arthritis 102

IV GRP78 Promotes Endothelial Cell Survival in Association with T-Cadherin 103

V Cripto Mitogenic Signaling is GRP78-Dependent 103

VI Interaction of GRP78 with Plasminogen Kringle 5 and Microplasminogen Leads to Apoptosis or the UPR 104

VII GRP78 Association with Extracellular Par-4 Activates the Extrinsic Apoptotic Pathway 105

VIII GRP78 Inhibits Tissue Factor-Mediated Procoagulant Activity 107

IX GRP78 Targeting Peptides Inhibit Tumor Growth 108

X Conclusions 109

References 110

6 On the Synergistic Effects of Ligand-Mediated and Phage-Intrinsic Properties During in Vivo Selection Wouter H. P. Driessen Lawrence F. Bronk Julianna K. Edwards Bettina Proneth Glauco R. Souza Paolo Decuzzi Renata Pasqualini Wadih Arap 115

I Introduction 116

II Ligand-Receptor Mediated Effects 118

III Synergistic Effects Intrinsic to Phage 124

IV Conclusion 130

References 130

7 Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy Prashanth Sreeramoju Steven K. Libutti 135

I Introduction 136

II Isolated Limb Perfusion 136

III Isolated Liver Perfusion 137

IV Chemoembolization 138

V Gene Therapy Strategies Available to Target the Tumor and the Tumor-Associated Vasculature 139

VI Conclusions 148

References 148

Index 153

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