Tissue-Specific vascular endothelial signals and vector targeting, Part B

Tissue-Specific vascular endothelial signals and vector targeting, Part B

by Elsevier Science
     
 

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

* Includes important reviews of the broadest interest to

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Overview

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

* Includes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines, providing researchers an overview and synthesis of the latest findings in the area
• Presents up-to-date research from leaders in the field

Product Details

ISBN-13:
9780123750228
Publisher:
Elsevier Science
Publication date:
09/27/2010
Pages:
174
Product dimensions:
6.00(w) x 9.10(h) x 0.60(d)

Table of Contents

Contributors ix

1 MR Molecular Imaging of Tumor Vasculature and Vascular Targets Arvind P. Pathak Marie-France Penet Zaver M. Bhujwalla 1

I Introduction 2

II Structural, Functional, and Molecular Characteristics of Tumor Vasculature 3

III Basis of Contrast in MR Images 7

IV Imaging Receptor Expression 16

V Imaging Vascular Targeting 17

VI Multimodal Molecular-Functional Imaging of Tumor Vasculature 19

VII Conclusion 21

References 22

2 An Integrated Approach for the Rational Design of Nanovectors for Biomedical Imaging and Therapy Biana Godin Wouter H. P. Driessen Bettina Proneth Sei-Young Lee Srimeenakshi Srinivasan Rolando Rumbaut Wadih Arap Renata Pasqualini Mauro Ferrari Paolo Decuzzi 31

I Introduction 32

II Three Generations of Nanovectors 34

III Mathematical Models for Predicting the Nanovectors' Behavior 39

IV Biophysical Characterization of Nanovectors 48

V Vascular Targeting Moieties 50

VI In vitro Assays for Nanovectors' Characterization 53

VII Intravital Video Microscopy 55

VIII Conclusions 57

References 59

3 Targeted Systemic Gene Therapy and Molecular Imaging of Cancer: Contribution of the Vascular-Targeted AAVP Vector Amin Hajitou 65

I Introduction 66

II Targeted Gene Delivery 68

III Conclusions and Perspectives 79

References 80

4 Cationic and Tissue-Specific Protein Transduction Domains: Identification, Characterization, and Therapeutic Application Maliha Zahid Xiaoli Lu Zhibao Mi Paul D. Robbins 83

I Introduction 84

II Cationic Protein Transduction Domains 84

III Biopanning using Peptide Phage Display Libraries 85

IV Peptide Phage Display Biopanning in Cell Culture for Transduction Peptides 87

V Methods for Analysis of Transduction Efficiency 90

VI Peptide Phage Display Biopanning in vivo for Transduction Peptides 91

VII PTDs as Therapeutics 92

VIII Conclusions 93

References 93

5 GRP78 Signaling Hub: A Receptor for Targeted Tumor Therapy Masanori Sato Virginia J. Yao Wadih Arap Renata Pasqualini 97

I Introduction 99

II GRP78 Association with Activated α2-Macroglobulin Promotes Cell Proliferation 101

III GRP78 Autoantibody Predicts Poor Prognosis in Tumors but Shows Therapeutic Effects in Rheumatoid Arthritis 102

IV GRP78 Promotes Endothelial Cell Survival in Association with T-Cadherin 103

V Cripto Mitogenic Signaling is GRP78-Dependent 103

VI Interaction of GRP78 with Plasminogen Kringle 5 and Microplasminogen Leads to Apoptosis or the UPR 104

VII GRP78 Association with Extracellular Par-4 Activates the Extrinsic Apoptotic Pathway 105

VIII GRP78 Inhibits Tissue Factor-Mediated Procoagulant Activity 107

IX GRP78 Targeting Peptides Inhibit Tumor Growth 108

X Conclusions 109

References 110

6 On the Synergistic Effects of Ligand-Mediated and Phage-Intrinsic Properties During in Vivo Selection Wouter H. P. Driessen Lawrence F. Bronk Julianna K. Edwards Bettina Proneth Glauco R. Souza Paolo Decuzzi Renata Pasqualini Wadih Arap 115

I Introduction 116

II Ligand-Receptor Mediated Effects 118

III Synergistic Effects Intrinsic to Phage 124

IV Conclusion 130

References 130

7 Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy Prashanth Sreeramoju Steven K. Libutti 135

I Introduction 136

II Isolated Limb Perfusion 136

III Isolated Liver Perfusion 137

IV Chemoembolization 138

V Gene Therapy Strategies Available to Target the Tumor and the Tumor-Associated Vasculature 139

VI Conclusions 148

References 148

Index 153

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