Tocotrienols: Vitamin E Beyond Tocotrienols

Tocotrienols: Vitamin E Beyond Tocotrienols

by Ronald Ross Watson
     
 

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ISBN-10: 1420080377

ISBN-13: 9781420080377

Pub. Date: 08/19/2008

Publisher: Taylor & Francis

A New Avenue of Research Beyond Traditional Studies of Vitamin E

In the current literature, more than 95% of all studies of vitamin E are directed toward the specific exploration of the bioactive component α-tocopherol. Until recently, there has been a dearth of research into non-tocopherol vitamin E molecules. A unique resource that examines

Overview

A New Avenue of Research Beyond Traditional Studies of Vitamin E

In the current literature, more than 95% of all studies of vitamin E are directed toward the specific exploration of the bioactive component α-tocopherol. Until recently, there has been a dearth of research into non-tocopherol vitamin E molecules. A unique resource that examines the newest developments in this area, Tocotrienols: Vitamin E Beyond Tocopherols focuses on the lesser-known vitamin E compound known as tocotrienol.

Explores Treatment Possibilities

Recognized as potent antioxidants, tocotrienols play a role in cholesterol reduction, tumor suppression, reversal of arteriosclerosis and protection of the heart against oxidative stress. Compiling contributions from leading researchers, this book builds upon a recent symposium sponsored by the American Oil Chemists Society. It begins with an overview of tocotrienols, and then examines their sources, chemistry and mechanisms of action. Contributors discuss the uses of tocotrienols in the prevention and treatment of cancer and heart disease, their metabolism and absorption and their potential in the treatment of infectious disease and neurodegeneration, as well as their use as a countermeasure against radiological threat.

For the past 10 years, Professors Ronald R. Watson and Victor R. Preedy have published books on bioactive nutrients and dietary supplements. Professor Watson has been and is currently funded to do research by grants from the American Heart Foundation and the U.S. National Institute of Heart, Lung, and Blood. By gathering the contributions contained in this volume, they have expanded the field of knowledge and forged a new path in disease treatment and prevention.

Product Details

ISBN-13:
9781420080377
Publisher:
Taylor & Francis
Publication date:
08/19/2008
Pages:
424
Product dimensions:
0.70(w) x 1.00(h) x 1.30(d)

Table of Contents

Introduction and Overview
Tocotrienols: A Review, A.G. Schauss
Tocotrienols in Vitamin E: Hype or Science?, N.E. Levin and D.L. Clouatre
Sources
Tocotrienols: Distribution and Sources Cereals—Role in Human Health, H. Zielinski
Tocotrienols in Plants: Sources and Importance, L. Harinantenaina
Vitamin E: Natural vs. Synthetic, A. Kosowski and D.L. Clouatre
Chemistry of Tocotrienols
Angiogenesis Inhibition, K. Nakagawa, A. Shibata, P. Sookwong and T. Miyazawa
Chemistry of Tocotrienols, S.P. Ghosh, M. Hauer-Jensen, and K.S. Kumar
Mechanisms of Action
Antioxidant Activity of Tocotrienols in Cells and Serum, R. Simone and P. Palozza
Antioxidant Action of Tocotrienols and Tocopherols in Solution and Membranes: Chemical and Physical Effects, Y. Yoshida and E. Niki
Antiproliferative and Apoptotic Effects of Tocotrienols on Normal and Neoplastic Mammary Epithelial Cells, P.W. Sylvester
DNA Polymerase Inhibition, Y. Mizushina, H. Yoshida, and T. Miyazawa
Tocotrienols in Altering the Expression of Adhesion Molecules, Y. Naito and T. Yoshikawa
Uptake, Distribution and Protective Action of Tocotrienols in Cultured Cells, N. Noguchi, Y. Saito and E. Niki
Cancer Prevention and Treatment
Anticancer Effects of Tocotrienols and Tocopherols Irrespective of Anti-Oxidative Properties, T. Yano and N. Virgona
Role of the MevalonatePathway in Tocotrienol-Mediated Tumor Suppression, H. Mo and C.E. Elson
Telomerase Inhibition, T. Eitsuka, K. Nakagawa and T. Miyazawa
Heart Disease
Tocopherol and Tocotrienols: Role in Heart Disease Care and Prevention, V. Juturu
Tocotrienols and the Regulation of Cholesterol Biosynthesis, J. Cao, W. Qi and B.-L. Song
Tocotrienols in Cardiometabolic Diseases, B. Tan and A.M. Mueller
Tocotrienols in Hyperlipidemic Conditions, J. Iqba1 and M. Minhajuddin
Vitamin E Isomers, Tocotrienols, in Cardioprotection, S. Das, M. Das and D.K. Das
Metabolism and Absorption
Absorption and Disposition of Tocotrienols, K.-H. Yuen, B.-H. Ng and J.-W. Wong
The Metabolism of Tocopherols and Tocotrienols and Novel Functions of Their Metabolites, Q. Jiang
Tocotrienols Activate the Steroid and Xenobiotic Receptor SXR to Modulate Small Molecule Metabolism, K.R. Johnson, T. Hsu, and B. Blumberg
Health Promotion
Tocotrienols in the Potential Treatment of Infectious Disease, A. M. Mueller, B. Tan and E. S. Stuart
Tocotrienols as Natural Neuroprotective Vitamins, C.K. Sen, S. Khanna and S. Roy
Gamma-Tocotrienol: Potential as a Countermeasure against Radiological Threat, K.S. Kumar, S.P. Ghosh and M. Hauer-Jensen
Index

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