Top Drugs: Top Synthetic Routesby John Saunders
Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of
Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis.
Description: This book is a concise introduction to pharmaceutically important classes of compounds. The author briefly describes both mechanism of action and methods of agent preparation. He incorporates many topics relevant to both human health and modern synthetic chemistry.
Purpose: The purpose is to introduce therapeutically important biological targets and then to provide routes to prepare the most important of the compounds.
Audience: The audience is senior students in the areas of organic and medicinal chemistry.
Features: The combination of the two topics represents an important contribution as they are seldom combined within a single volume. With this approach the author provides insight into the life of a practicing medicinal chemist. The He also provides an introduction to a broad range of structures found in therapeutically interesting molecules. Structures discussed include heterocycles, peptidomimetics, and nucleosides. The author typically describes routes and reactions that research chemists use to synthesize the materials as commercial routes are not in the public domain. Many of the reagents discussed are not used commercially today (benzene and chloroform, for example). The schemes are generally well organized and informative. The author provides leading references that will allow a student to elaborate on topics of interest.
Assessment: This is a good introduction to the synthetic chemistry required to fuel the pharmaceutical industry and should encourage students to pursue a career in this exciting field. The book is short by design but the author does omit several important classes of compounds including anticancer agents, hormone regulators including steroids, and a broad discussion of antibiotics. A second edition is merited to incorporate these additional classes and to address typographical errors.
Meet the Author
and post it to your social network
Most Helpful Customer Reviews
See all customer reviews >