BN.com Gift Guide

Top Drugs: Top Synthetic Routes

Overview

Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to ...

See more details below
Available through our Marketplace sellers.
Other sellers (Paperback)
  • All (4) from $23.52   
  • New (2) from $23.52   
  • Used (2) from $23.52   
Close
Sort by
Page 1 of 1
Showing All
Note: Marketplace items are not eligible for any BN.com coupons and promotions
$23.52
Seller since 2008

Feedback rating:

(17789)

Condition:

New — never opened or used in original packaging.

Like New — packaging may have been opened. A "Like New" item is suitable to give as a gift.

Very Good — may have minor signs of wear on packaging but item works perfectly and has no damage.

Good — item is in good condition but packaging may have signs of shelf wear/aging or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Acceptable — item is in working order but may show signs of wear such as scratches or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Used — An item that has been opened and may show signs of wear. All specific defects should be noted in the Comments section associated with each item.

Refurbished — A used item that has been renewed or updated and verified to be in proper working condition. Not necessarily completed by the original manufacturer.

New
Brand New, Perfect Condition, Please allow 4-14 business days for delivery. 100% Money Back Guarantee, Over 1,000,000 customers served.

Ships from: Westminster, MD

Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
$26.12
Seller since 2008

Feedback rating:

(4519)

Condition: New
New Book. Shipped from UK within 4 to 14 business days. Established seller since 2000.

Ships from: Horcott Rd, Fairford, United Kingdom

Usually ships in 1-2 business days

  • Standard, 48 States
  • Standard (AK, HI)
Page 1 of 1
Showing All
Close
Sort by
Sending request ...

Overview

Today's top selling drugs have been uncovered from two major sources: natural products and laboratory synthesis. Those synthesised directly by medicinal chemists usually have been the result of a protracted discovery programme using a natural product (e.g. a hormone or an enzyme substrate) or a screening lead as a starting point. Many of the major categories of human disease cardiovascular, gastrointestinal, central nervous system, inflammatory and infectious diseases are included. After a short introduction to the discovery and mechanism of action of each drug, the syntheses of the best selling drugs are reviewed. Where the information exists in the literature, the original research method to each drug is compared with more recent approaches which aim either at improving the route or at validating newer methodologies or reagents in the context of drug synthesis. Since, for many drugs, the marketed product was originally prepared as a racemic mixture, perhaps the most important comparison is between that route and alternatives which involve some element of asymmetric synthesis.

The book contains black-and-white illustrations.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Stephen A. Munk, PhD (Ash Stevens Inc.)
Description: This book is a concise introduction to pharmaceutically important classes of compounds. The author briefly describes both mechanism of action and methods of agent preparation. He incorporates many topics relevant to both human health and modern synthetic chemistry.
Purpose: The purpose is to introduce therapeutically important biological targets and then to provide routes to prepare the most important of the compounds.
Audience: The audience is senior students in the areas of organic and medicinal chemistry.
Features: The combination of the two topics represents an important contribution as they are seldom combined within a single volume. With this approach the author provides insight into the life of a practicing medicinal chemist. The He also provides an introduction to a broad range of structures found in therapeutically interesting molecules. Structures discussed include heterocycles, peptidomimetics, and nucleosides. The author typically describes routes and reactions that research chemists use to synthesize the materials as commercial routes are not in the public domain. Many of the reagents discussed are not used commercially today (benzene and chloroform, for example). The schemes are generally well organized and informative. The author provides leading references that will allow a student to elaborate on topics of interest.
Assessment: This is a good introduction to the synthetic chemistry required to fuel the pharmaceutical industry and should encourage students to pursue a career in this exciting field. The book is short by design but the author does omit several important classes of compounds including anticancer agents, hormone regulators including steroids, and a broad discussion of antibiotics. A second edition is merited to incorporate these additional classes and to address typographical errors.
Stephen A. Munk
This book is a concise introduction to pharmaceutically important classes of compounds. The author briefly describes both mechanism of action and methods of agent preparation. He incorporates many topics relevant to both human health and modern synthetic chemistry. The purpose is to introduce therapeutically important biological targets and then to provide routes to prepare the most important of the compounds. The audience is senior students in the areas of organic and medicinal chemistry. The combination of the two topics represents an important contribution as they are seldom combined within a single volume. With this approach the author provides insight into the life of a practicing medicinal chemist. The He also provides an introduction to a broad range of structures found in therapeutically interesting molecules. Structures discussed include heterocycles, peptidomimetics, and nucleosides. The author typically describes routes and reactions that research chemists use to synthesize the materials as commercial routes are not in the public domain. Many of the reagents discussed are not used commercially today (benzene and chloroform, for example). The schemes are generally well organized and informative. The author provides leading references that will allow a student to elaborate on topics of interest. This is a good introduction to the synthetic chemistry required to fuel the pharmaceutical industry and should encourage students to pursue a career in this exciting field. The book is short by design but the author does omit several important classes of compounds including anticancer agents, hormone regulators including steroids, and a broad discussion of antibiotics. Asecond edition is merited to incorporate these additional classes and to address typographical errors.

3 Stars from Doody
Read More Show Less

Product Details

  • ISBN-13: 9780198501008
  • Publisher: Oxford University Press, USA
  • Publication date: 7/12/2012
  • Series: Oxford Chemistry Primers Series , #90
  • Edition description: New Edition
  • Pages: 96
  • Product dimensions: 9.30 (w) x 7.00 (h) x 0.30 (d)

Table of Contents

1 Inhibitors of angiotensin converting enzyme as effective antihypertensive agents 1
2 Blockade of angiotensin-II receptors 16
3 Calcium channel blockers in the treament of angina and hypertension 21
4 Antagonists of histamine receptors (H[subscript 2]) as anti-ulcer remedies 31
5 Proton pump inhibitors as gastric acid secretion inhibitors 37
6 Modulation of central serotonin in the treatment of depression 43
7 Hypnotic, anxiolytic, anticonvulsant and muscle relaxant agents: ligands for benzodiazepine receptors 52
8 Another histamine receptor: blockers of the H[subscript 1] receptor for the treatment of seasonal allergic rhinitis 61
9 Nucleoside analogues which inhibit HIV reverse transcriptase 71
10 Quinolones as anti-bacterial DNA gyrase inhibitors 80
Abbreviations 88
Index 89
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)