Toxicology and Human Environments

by Elsevier Science

Overview

Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments.

The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis.

• Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health
• Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them

Product Details

ISBN-13:	9780124159082
Publisher:	Elsevier Science
Publication date:	12/31/2012
Series:	ISSN , #112
Sold by:	Barnes & Noble
Format:	eBook
Pages:	450
File size:	6 MB

About the Author

Dr Ernest Hodgson, Distinguished Professor Emeritus, North Carolina State University and Executive Director, Foundation for Toxicology and Agromedicine was educated at King’s College of the University of Durham (now the University of Newcastle), Oregon State University and the University of Wisconsin. At North Carolina State University since 1961 he was a William Neal Reynolds Professor and Head of the newly formed Department of Toxicology. He was also one of the founders of the three university (East Carolina University, North Carolina State University and North Carolina A&T University) program in agromedicine, an organization which led to the formation of the North Carolina Agromedicine Institute.

Dr. Hodgson has conducted research on xenobiotic biochemistry for several decades, has authored c. 400 peer-reviewed papers in this area, and is editor and part author of several monographs. Most recently his research has focused on human studies utilizing human hepatocytes and sub-cellular preparations. Currently involved as a collaborator with Dr Michael Roe in RNAseq studies of genome-wide effects of environmental chemicals. From 1961 until his retirement he was supported by extramural funding, primarily from NIH (NIEHS) and the US Army.

Dr Hodgson is also editor and contributing author of toxicology textbooks (Textbook of Modern Toxicology and Molecular and Biochemical Toxicology, both currently in their 4th editions) and is a lexicographer (Dictionary of Toxicology, under revision for a 3rd edition and a Dictionary of Agromedicine, being created for the NC Agromedicine Institute). He is well recognized for his role as a teacher of toxicology. In addition to his role as editor and part author of textbooks he has trained some 40 graduate students and 20 post-doctoral research associates.

His service on federal study sections and other federal panels has been extensive and includes the following agencies. NIH, NASA, US Army and others. He has been recognized by awards from the Society of Toxicology, the American Chemical Society, the International Society for the Study of Xenobiotics, the Consolidated University of North Carolina and North Carolina State University. He is a past president of the International Society for the Study of Xenobiotics.

Table of Contents

1. Human Environments: Definition, Scope and the Role of Toxicology

Ernest Hodgson

2. Estimating Human Exposure: Improving Accuracy with Chemical Markers

Roger C. Cochran and Jeffrey H. Driver

3. Metabolism of Xenobiotics Human Environments

Edward Croom

4. Toxic Endpoints in the Study of Human Exposure to Environmental Chemicals

Andrew D. Wallace

5. Pesticide Regulations: Exposure-Dose Modeling from FIFRA to FQPA

James B. Knaak, Cecilla Tan and Curt C. Dary

6. Occupational Chemicals: Metabolism, Toxicity and Mode of Action

Sheila Flack and Leena A. Nylander-French

7. Chemicals of Military Deployments: Revisiting Gulf War Syndrome in Light of New Information

A.A. Brimfield

8. Pharmaceuticals in the Environment: Lessons Learned for Reducing Uncertainties in Environmental Risk Assessment

Bryan W. Brooks, Jason P. Berninger, Lauren A. Kristofco, Alejandro J. Ramirez, Jacob K. Stanley and Theodore W. Valenti

9. Quantitative Risk Assessment Methods for Cancer and Non-Cancer Effects

Ronald E. Baynes

10. Human Health Risk Assessment for Contaminated Properties

Atul M. Salhotra

11. The Future of Human Health Risk Assessment of Environmental Chemicals.

Ernest Hodgson

12. Ecological Risk Assessment

Damian Shea and Waverly Thorsen

13. Metabolic Interactions of Environmental Toxicants in Humans

Ernest Hodgson

14. Toxins and Venoms

Ernest Hodgson

15. Summary and Conclusions

Ernest Hodgson

Editorial Reviews

Praise for the series: "Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell." —British Medical Journal

From the Publisher