Toxicology of Organophosphate & Carbamate Compounds

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Overview

This book brings together the expertise of leading scientists from around the world on the complex toxicology of anticholinesterase compounds (Organophosphates and Carbamates) . It provides the most up-to-date and in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements

Anticholinesterase compounds constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used both in chemical warfare and terrorist attacks; while other OPs and CMs have been recommended as therapeutic agents in human and veterinary medicine.

Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent and accidental use continues to pose a threat to human and animal health, aquatic systems, and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and non-target organs. These are some of the contributing factors that make this class of agents so very important and will make this book a crucial reference work for every researcher dealing with these agents.

• Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants

• Describes epidemiology of the world’s major disasters involving Organophosphates and Carbamates

• Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases

• Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity

• Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis

• Provides in vitro and in vivo models for neurotoxicity testing

• Integrates knowledge of studies in lab animals and humans

• Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues

• Describes management of Anticholinesterase poisoning in humans

This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs.

In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides.

-Describes everything you need to know aboutOrganophosphates and Carbamates
-Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants
-Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates
-Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases
-Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity
-Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis
-Provides in vitro and in vivo models for neurotoxicity testing
-Integrates knowledge of studies in lab animals and humans
-Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues
-Describes management of Anticholinesterase poisoning in human

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Editorial Reviews

From the Publisher
"...the text of the volume has been well organized giving appropriate tables, figures in depth and comprehensive manner, covering important and novel issues."
- Prof P.K.Gupta, Adviser to WHO and Director TCS Inc., Bareilly, India for TOXICOLOGY INTERNATIONAL (June 2006)
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Product Details

  • ISBN-13: 9780120885237
  • Publisher: Elsevier Science
  • Publication date: 12/27/2005
  • Pages: 768
  • Product dimensions: 11.00 (w) x 8.70 (h) x 1.60 (d)

Meet the Author

Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer(s) disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including six major books: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, and (6) Biomarkers in Toxicology. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.
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Table of Contents

Foreword
Section-I Uses, Abuses & Epidemiology
Section-II Pharmacokinetics & Metabolism
Section-III Esterases, Receptors, Mechanisms & Tolerance Development
Section-IV Organ Toxicity
Section-V Non-Specific Toxic Effects
Section-VI Risk Assessment & Regulations
Section-VII Aquatic & Wildlife
Section-VIII Analytical & Biomarkers
Section-IX Therapeutic Measures
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