Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods

Overview

This new edition of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and ...

See more details below
Hardcover (New Edition)
$171.93
BN.com price
(Save 14%)$199.95 List Price
Other sellers (Hardcover)
  • All (3) from $161.59   
  • New (2) from $161.59   
  • Used (1) from $171.92   
Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods

Available on NOOK devices and apps  
  • NOOK Devices
  • Samsung Galaxy Tab 4 NOOK
  • NOOK HD/HD+ Tablet
  • NOOK
  • NOOK Color
  • NOOK Tablet
  • Tablet/Phone
  • NOOK for Windows 8 Tablet
  • NOOK for iOS
  • NOOK for Android
  • NOOK Kids for iPad
  • PC/Mac
  • NOOK for Windows 8
  • NOOK for PC
  • NOOK for Mac
  • NOOK for Web

Want a NOOK? Explore Now

NOOK Book (eBook)
$199.95
BN.com price

Overview

This new edition of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

Read More Show Less

Editorial Reviews

From the Publisher

"The field was in need of this new edition because of the information burst that has occurred with the sequencing of the genome which has led to tractable genetic systems. A one source resource for these molecular techniques is essential to the continuing progress in this research field." – Melanie T. Cushion, Ph.D., Professor and Associate Chair for Research, Division of Infectious Diseases, University of Cincinnati College of Medicine, Ohio

From the Publisher
"The field was in need of this new edition because of the information burst that has occurred with the sequencing of the genome which has led to tractable genetic systems. A one source resource for these molecular techniques is essential to the continuing progress in this research field." - Melanie T. Cushion, Ph.D., Professor and Associate Chair for Research, Division of Infectious Diseases, University of Cincinnati College of Medicine, Ohio
From The Critics
Reviewer: Rebecca T. Horvat, PhD, D(ABMM)(University of Kansas Medical Center)
Description: This up-to-date review of the current information and research on Toxoplasma gondii, a parasite that infects a large number of animals, including humans, provides a base for future investigations and therapies.
Purpose: This book evolved from the International Congress on Toxoplasmosis in 2003, where it was noted that the study of this ubiquitous pathogen had developed rapidly in the last 10 years. Although there was an increasing interest in Toxoplasma gondii, there was no single source of current information on the research with this organism. This book has done a good job of presenting recent research on this organism in the context of historical data.
Audience: It is written primarily for researchers studying toxoplasmosis. Additionally, it could be used as a textbook in an advanced undergraduate or graduate course. The authors are all experienced researchers in this area.
Features: The authors have done a good job of reviewing historical literature and then moving into a discussion of the more recent research in this field. The book is comprehensive and covers topics such as animal models used in research and investigation of the innate and adaptive immune response to toxoplasmosis. These chapters allow the reader to appreciate why Toxoplasma gondii are established in a large number of animal species, including humans. It is noted that this parasite has a wide spectrum of host animals and can present a problem in wild species, zoo animals, and pets. Several chapters discuss the process of host cell invasion by the parasite and then in contrast show the mechanism used to kill toxoplasmosis inside professional phagocytes. Additional chapters explore the use of cell culture models to discover new therapeutic agents. Some of these chapters give detailed information on the techniques used to culture this parasite. Other topics covered include the discovery of toxoplasma-specific proteins, new diagnostic tests, treatment options, and vaccine development to control spread of disease.
Assessment: This is a valuable resource for scientists working on this organism. There are few other current books that cover this topic so comprehensively. I anticipate that it will provide a springboard for further collaboration and experimentation on this fascinating pathogen.
Read More Show Less

Product Details

  • ISBN-13: 9780123964816
  • Publisher: Elsevier Science
  • Publication date: 10/10/2013
  • Edition description: New Edition
  • Edition number: 2
  • Pages: 1160
  • Product dimensions: 7.60 (w) x 9.40 (h) x 2.30 (d)

Meet the Author

Louis M. Weiss M.D., M.P.H is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center.

Kami Kim M.D. is Professor of Medicine (Division of Infectious Diseases), Professor of Pathology (Division of Parasitology and Tropical Medicine) and Professor of Microbiology and Immunology of the Albert Einstein College of Medicine, Bronx, New York. Dr. Kim received her M.D. degree from Columbia College of Physicians and Surgeons in 1984. She trained in internal medicine at Columbia Presbyterian Medical Center and in infectious diseases at the University of California, San Francisco. Following her clinical training, she did a postdoctoral fellowship in the Department of Microbiology & Immunology at Stanford University School of Medicine, after which she joined the faculty at Einstein where she is currently a Professor of Medicine, Pathology and Microbiology and Immunology. Her laboratory research is focused upon understanding the pathogenesis of toxoplasmosis and malaria. Recently she has developed collaborations with clinical investigators at the Blantyre Malaria Project in Malawi to understand the clinical impact of HIV co-infection upon cerebral malaria. She is also interested in understanding epigenetic and genetic factors that govern the host response to parasitic infections, opportunistic pathogens and tuberculosis. Dr. Kim is a fellow of the American Academy of Microbiology and the Infectious Disease Society of America and an elected member of the Association for American Physcians and the American Society for Clinical Investigation.

Read More Show Less

Table of Contents

Preface 1. The History and Life Cycle of Toxoplasma gondii 2. The Ultrastructure of Toxoplasma gondii 3. Population Structure and Epidemiology of Toxoplasma gondii 4. Toxoplasma Clinical Disease and Diagnostics 5. Ocular Disease 6. Toxoplasmosis in Wild and Domestic Animals 7. Toxoplasma Animal Models and Therapeutics 8. Biochemistry, Lipids, Glycobiology and Metabolism of Toxoplasma gondii 9. The Apicoplast and Mitochondrion of Toxoplasma gondii 10. Calcium Storage and Homeostasis in Toxoplasma gondii 11. The Parasitophorous Vacuole: an organelle for the host pathogen interface 12. Toxoplasma Secretory Organelles: Rhoptries, Micronemes and Dense Granules 13. The Cytoskelton: Structure and Motility 14. Alterations in Host Cell Biology due to Toxoplasma gondii 15. Bradyzoite Development 16. Development and Application of Classical Genetics in Toxoplasma gondii 17. Genetic Manipulation 18. Gene Regulation and Epigenomics 19. Genomic Analysis and Bioinformatics 20. Comparative Aspects of Nucleotide and Amino Acid Metabolism in Toxoplasma gondii and other Apicomplexa 21. Chemical Biology and Toxoplasma as a Model System for Drug Discovery 22. Proteomics of Toxoplasma gondii 23. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioural Consequences 24. Innate Immunity in Toxoplasma Infection 25. Adaptive Immunity and host Genetics 26. Toxoplasma gondii vaccines Epilogue: Toxoplasma as a Model Organism

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)