Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods by Louis M. Weiss, Kami Kim |, Hardcover | Barnes & Noble
Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods

Toxoplasma Gondii: The Model Apicomplexan - Perspectives and Methods

by Louis M. Weiss, Kami Kim
     
 

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This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire

Overview

This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.

  • Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogen
  • Provides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosis
  • Offers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists

Editorial Reviews

From the Publisher
"The field was in need of this new edition because of the information burst that has occurred with the sequencing of the genome which has led to tractable genetic systems. A one source resource for these molecular techniques is essential to the continuing progress in this research field." - Melanie T. Cushion, Ph.D., Professor and Associate Chair for Research, Division of Infectious Diseases, University of Cincinnati College of Medicine, Ohio

Reviewer: Rebecca T. Horvat, PhD, D(ABMM)(University of Kansas Medical Center)
Description: This up-to-date review of the current information and research on Toxoplasma gondii, a parasite that infects a large number of animals, including humans, provides a base for future investigations and therapies.
Purpose: This book evolved from the International Congress on Toxoplasmosis in 2003, where it was noted that the study of this ubiquitous pathogen had developed rapidly in the last 10 years. Although there was an increasing interest in Toxoplasma gondii, there was no single source of current information on the research with this organism. This book has done a good job of presenting recent research on this organism in the context of historical data.
Audience: It is written primarily for researchers studying toxoplasmosis. Additionally, it could be used as a textbook in an advanced undergraduate or graduate course. The authors are all experienced researchers in this area.
Features: The authors have done a good job of reviewing historical literature and then moving into a discussion of the more recent research in this field. The book is comprehensive and covers topics such as animal models used in research and investigation of the innate and adaptive immune response to toxoplasmosis. These chapters allow the reader to appreciate why Toxoplasma gondii are established in a large number of animal species, including humans. It is noted that this parasite has a wide spectrum of host animals and can present a problem in wild species, zoo animals, and pets. Several chapters discuss the process of host cell invasion by the parasite and then in contrast show the mechanism used to kill toxoplasmosis inside professional phagocytes. Additional chapters explore the use of cell culture models to discover new therapeutic agents. Some of these chapters give detailed information on the techniques used to culture this parasite. Other topics covered include the discovery of toxoplasma-specific proteins, new diagnostic tests, treatment options, and vaccine development to control spread of disease.
Assessment: This is a valuable resource for scientists working on this organism. There are few other current books that cover this topic so comprehensively. I anticipate that it will provide a springboard for further collaboration and experimentation on this fascinating pathogen.

Product Details

ISBN-13:
9780123964816
Publisher:
Elsevier Science
Publication date:
10/10/2013
Edition description:
New Edition
Pages:
1160
Product dimensions:
7.60(w) x 9.40(h) x 2.30(d)

Meet the Author

Louis M. Weiss M.D., M.P.H is Professor of Medicine (Division of Infectious Diseases) and Professor of Pathology (Division of Parasitology and Tropical Medicine) of the Albert Einstein College of Medicine, Bronx, New York. Dr. Weiss received his M.D. and M.P.H degrees from the Johns Hopkins University in 1982. He then completed a residency in Internal Medicine at the University of Chicago and a fellowship in Infectious Diseases at the Albert Einstein College of Medicine. Following this fellowship, he joined the faculty at Einstein where he is currently a Professor of Pathology and Medicine. His laboratory group has an active research program on parasitic diseases with a research focus on Toxoplasma gondii, the Microsporidia and Trypanosoma cruzi. Dr. Weiss is the author of over 200 publications and the editor of 3 books on parasitology. He is a fellow of the American College of Physicians, Infectious Disease Society of America and the American Academy of Microbiology. Dr. Weiss is the Co-Director of the Einstein Global Health Center.

Kami Kim M.D. is Professor of Medicine (Division of Infectious Diseases), Professor of Pathology (Division of Parasitology and Tropical Medicine) and Professor of Microbiology and Immunology of the Albert Einstein College of Medicine, Bronx, New York. Dr. Kim received her M.D. degree from Columbia College of Physicians and Surgeons in 1984. She trained in internal medicine at Columbia Presbyterian Medical Center and in infectious diseases at the University of California, San Francisco. Following her clinical training, she did a postdoctoral fellowship in the Department of Microbiology & Immunology at Stanford University School of Medicine, after which she joined the faculty at Einstein where she is currently a Professor of Medicine, Pathology and Microbiology and Immunology. Her laboratory research is focused upon understanding the pathogenesis of toxoplasmosis and malaria. Recently she has developed collaborations with clinical investigators at the Blantyre Malaria Project in Malawi to understand the clinical impact of HIV co-infection upon cerebral malaria. She is also interested in understanding epigenetic and genetic factors that govern the host response to parasitic infections, opportunistic pathogens and tuberculosis. Dr. Kim is a fellow of the American Academy of Microbiology and the Infectious Disease Society of America and an elected member of the Association for American Physcians and the American Society for Clinical Investigation.

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