Transcription Factors and Human Disease / Edition 1

Transcription Factors and Human Disease / Edition 1

by Gregg L. Semenza
     
 

Several general principles have emerged from the study of human transc ription factors. First, germline mutations in genes encoding transcrip tion factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations in volving many of the same genes contribute to tumorigenesis. Third, tra nscriptional

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Overview

Several general principles have emerged from the study of human transc ription factors. First, germline mutations in genes encoding transcrip tion factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations in volving many of the same genes contribute to tumorigenesis. Third, tra nscriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology a re unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and t he expression within the differentiated cells of gene products that pa rticipate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulatio n and then describes inherited human diseases attributable to mutation s in DNA sequences encoding transcription factors or their cognate bin ding sites.

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Product Details

ISBN-13:
9780195112399
Publisher:
Oxford University Press, USA
Publication date:
01/28/1999
Series:
Oxford Monographs on Medical Genetics Series, #37
Edition description:
New Edition
Pages:
384
Product dimensions:
6.40(w) x 9.30(h) x 1.30(d)

Table of Contents

Pt. ITranscriptional Regulation
1Gene Expression and Transcriptional Regulation3
2Cis-acting Transcriptional Regulatory Elements26
3Trans-acting Factors42
Pt. IITranscriptional Pathophysiology
4Mutations in Cis-acting Transcriptional Regulatory Elements113
5Mutations in Genes Encoding Transcription Factors: The Nuclear Receptor Superfamily127
6Other Zinc Finger Proteins: WT1 and GL13155
7PAX Proteins169
8bHLH Proteins199
9Homeodomain Proteins212
10HMG Domain Proteins247
11POU Domain Proteins261
12Other Transcription Factor Families272
13Coactivators289
14General Transcription Factors299
15Somatic Cell Genetic Disease: Cancer310
16Epigenetic Disease: Teratogenesis347
Index359

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