Transcription Factors in the Nervous System: Development, Brain Function, and Diseases / Edition 1

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This first book to cover neural development, neuronal survival and function on the genetic level outlines promising approaches for novel therapeutic strategies in fighting neurodegenerative disorders, such as Alzheimer's disease. Focusing on transcription factors, the text is clearly divided into three sections devoted to transcriptional control of neural development, brain function and transcriptional dysregulation induced neurological diseases.
With a chapter written by Nobel laureate Eric Kandel, this is essential reading for neurobiologists, geneticists, biochemists, cell biologists, neurochemists and molecular biologists.
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Editorial Reviews

From the Publisher
"…this volume presents critical information for neuroscientists while also providing a valuable resource for biologists, chemists, and geneticists in related fields or in biomedical research." (The Quarterly Review of Biology, December 2006)

"This is a great buy for those who deal with this matter on a daily basis." (Doody's Health Services)

Doody's Review Service
Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: Since Watson and Crick deciphered the DNA structure, the mechanisms of control of genetic transcription and encoding have been explored. Transcription factors have been discovered and showed to regulate genetic transcription. Their presence or absence will determine directions in development as well as mechanisms of disease, including degenerative neurological conditions.
Purpose: The purpose of this book is to address multiple transcription factors involved in the processing of information in the brain.
Audience: Neuroscientists are the main audience for this book. Different areas of interest may subdivide the group further into those scientists interested the study of neurodegenerative and genetic disorders of the nervous system. The editor is one of the most prominent authorities in the field and the contributors are from research institutions around the world.
Features: Since this is more of an expert's book on transcription factors, it would be most accessible to those dealing with these problems everyday. This is a great buy for those who deal with this matter on a daily basis.
Assessment: This is an appropriate purchase for neuroscience libraries. However, areas of focus should include molecular biology and neurodevelopment, since that's a good proportion of the research applications of this material.
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Product Details

  • ISBN-13: 9783527312856
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 3/6/2006
  • Edition number: 1
  • Pages: 505
  • Product dimensions: 7.00 (w) x 9.60 (h) x 1.20 (d)

Meet the Author

Since 1997 Gerald Thiel has been professor for Medical Biochemistry and Molecular Biology at the University of the Saarland, Germany. In 1987 he started his career as a post-doc at The Rockefeller University, New York, in the lab of the 2000 Nobel Prize Laureate Paul Greengard. At the same time he was visiting fellow at the Howard Hughes Medical Institute, University of Texas. In 1991 and 1992 he worked as an assistant professor for Molecular and Cellular Neuroscience at The Rockefeller University, and from 1992 to 1997 he was head of lab at the Institute for Genetics, University of Cologne, Germany. His current research interests are the regulation of neuronal gene transcription, signal transduction in the nervous system and the regulation of proliferation and programmed cell death in the nervous system.
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Table of Contents

Roles of Hes bHLH Factors in Neuronal Development
The Role of Pax6 in the Nervous System During Development and in Adulthood -
Master Control Regulator or Modular Function?
Phox2a and Phox2b Essential Transcription Factors or Neuron Specification and Differentiation
Functions of LIM-Homedomain Proteins in the Development of the Nervous System
Function of SRF and Ternary Complex Factors in the Nervous System
RE-1 Silencing Transcription Factor (REST) -
Regulation of Neuronal Gene Expression Via Modification of the Chromatin Structure
Roles of Tix1 and TIX3 and Neuronal Activity in Controlling Glutamatergic Over GABAergic Cell Fates
Transcriptional Control of the Development of Central Serotoneric Neurons
Role of Nkx Homeodomain Factors in the Specification and Differentiation of Motor Neurons and Oligodendrocytes
Sox Transcription Factors in Neural Development
Role of CREB and CBP in Brain Function
CCAAT Enhancer Binding Proteins in the Nervous System: Their Role in Development, Differentiation, Long-term Synaptic Plasticity and Memory
Role of c-Jun in Brain Function
Expression, Function, and Regulation of Transcription Factor MEF2 in Neurons
RORalpha, an Orphan that Staggers the Mind
Role of NF-kappaB in Brain Function
Calcineurin/NFAT Signaling in Development and Function of the Nervous System
Stimulus-Transcription Coupling in the Nervous System -
The Zinc Finger Protein Egr-1
The Presenilin/gamma-Secretase Complex Regulates Production of Transcriptional Factors: Effects of FAD Mutations
Transcriptional Abnormalities in Huntington's Disease
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