Transcriptional Control Of Neural Crest Development

Overview

The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, ...
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Overview

The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, nonmigratory population to a wide array of dynamic, differentiated cell types-some of which retain stem cell characteristics presumably to replenish these derivatives-requires a complex network of molecular switches to control the gene programs giving these cells their defi ning structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specifi c transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state.

Table of Contents: Introduction / AP Genes / bHLH Genes / ETS Genes / Fox Genes / Homeobox Genes / Hox Genes / Lim Genes / Pax Genes / POU Domain Genes / RAR/RXR Genes / Smad Genes / Sox Genes / Zinc Finger Genes / Other Miscellaneous Genes / References / Author Biographies

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Editorial Reviews

Doody's Review Service
Reviewer: Salvador Soriano, PhD (Loma Linda University)
Description: The authors have compiled a comprehensive list of currently known transcription factors that are relevant to neural crest development.
Purpose: Part of a series on developmental biology, this book aims to provide mechanistic and conceptual insights on the specific area of transcriptional control of neuronal crest development.
Audience: It will be of most value to readers already knowledgeable in this area. The authors are recognized experts in their field and they do an excellent job of compiling and summarizing the information.
Features: The book is overwhelming in its very thorough attention to detail, but the narrative is not engaging; rather, it reads like a thorough reference guide dense with information on each transcription factor. This is not a criticism, but this approach, while being particularly useful to scientists already well versed in the field, is unlikely to engage a wider range of scientists and students looking to gain background on the subject. The choice of illustrations does not help with this problem. The book lists six figures that show whole-mount in situ hybridization patterns of several transcription factors in mouse, chicken, fish and frog that are of limited value. The authors do include a schematic diagram of the distribution of transcription factors and their functional interplay in different neural crest lineages, which is a useful addition, but, unfortunately, key information is color-coded in my black-and-white copy, somewhat limiting its value.
Assessment: This is an exhaustive list of the currently known transcription factors that are relevant to neural crest development. For each transcription factor, the book contains, in exquisite detail, updated information on its spatial and temporal patterns of expression, specific roles, and functional links to other molecular players in the context of neural crest development. As a book aiming to engage a wide range of scientists, students, and clinicians, it is of limited value. However, as a thorough reference guide for experts in the field, this book has outstanding value.
Doody Reviews
Reviewer: Salvador Soriano, PhD (Loma Linda University)
Description: The authors have compiled a comprehensive list of currently known transcription factors that are relevant to neural crest development.
Purpose: Part of a series on developmental biology, this book aims to provide mechanistic and conceptual insights on the specific area of transcriptional control of neuronal crest development.
Audience: It will be of most value to readers already knowledgeable in this area. The authors are recognized experts in their field and they do an excellent job of compiling and summarizing the information.
Features: The book is overwhelming in its very thorough attention to detail, but the narrative is not engaging; rather, it reads like a thorough reference guide dense with information on each transcription factor. This is not a criticism, but this approach, while being particularly useful to scientists already well versed in the field, is unlikely to engage a wider range of scientists and students looking to gain background on the subject. The choice of illustrations does not help with this problem. The book lists six figures that show whole-mount in situ hybridization patterns of several transcription factors in mouse, chicken, fish and frog that are of limited value. The authors do include a schematic diagram of the distribution of transcription factors and their functional interplay in different neural crest lineages, which is a useful addition, but, unfortunately, key information is color-coded in my black-and-white copy, somewhat limiting its value.
Assessment: This is an exhaustive list of the currently known transcription factors that are relevant to neural crest development. For each transcription factor, the book contains, in exquisite detail, updated information on its spatial and temporal patterns of expression, specific roles, and functional links to other molecular players in the context of neural crest development. As a book aiming to engage a wide range of scientists, students, and clinicians, it is of limited value. However, as a thorough reference guide for experts in the field, this book has outstanding value.
From The Critics
Reviewer: Salvador Soriano, PhD(Loma Linda University)
Description: The authors have compiled a comprehensive list of currently known transcription factors that are relevant to neural crest development.
Purpose: Part of a series on developmental biology, this book aims to provide mechanistic and conceptual insights on the specific area of transcriptional control of neuronal crest development.
Audience: It will be of most value to readers already knowledgeable in this area. The authors are recognized experts in their field and they do an excellent job of compiling and summarizing the information.
Features: The book is overwhelming in its very thorough attention to detail, but the narrative is not engaging; rather, it reads like a thorough reference guide dense with information on each transcription factor. This is not a criticism, but this approach, while being particularly useful to scientists already well versed in the field, is unlikely to engage a wider range of scientists and students looking to gain background on the subject. The choice of illustrations does not help with this problem. The book lists six figures that show whole-mount in situ hybridization patterns of several transcription factors in mouse, chicken, fish and frog that are of limited value. The authors do include a schematic diagram of the distribution of transcription factors and their functional interplay in different neural crest lineages, which is a useful addition, but, unfortunately, key information is color-coded in my black-and-white copy, somewhat limiting its value.
Assessment: This is an exhaustive list of the currently known transcription factors that are relevant to neural crest development. For each transcription factor, the book contains, in exquisite detail, updated information on its spatial and temporal patterns of expression, specific roles, and functional links to other molecular players in the context of neural crest development. As a book aiming to engage a wide range of scientists, students, and clinicians, it is of limited value. However, as a thorough reference guide for experts in the field, this book has outstanding value.
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