Overview

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes.

Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may ...

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Transgenerational Epigenetics

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Overview

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes.

Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations.

This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research.



  • Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes
  • Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies
  • Covers history, future outlook, disease management and current controversies
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Editorial Reviews

Doody's Review Service
Reviewer: Luis F. Escobar, MD, MS (St. Vincent Hospital and Health Care Center)
Description: Epigenetics is a relatively new concept that has faced some neglect from the medical community. However, rapid advances in technology have placed this fascinating and important area of genomics in the forefront. Epigenetics explains mechanisms of disease in humans that previously could not be completely explained by traditional genetics concepts. Wonderfully designed and full of provocative subjects, this book is written by a good number of experts on transgenerational epigenetics.
Purpose: The intent is to expose and review the vast amount of information on epigenetics, which is difficult to find in detail in other books. This book is the first to be devoted in its entirety to transgenerational epigenetics. The authors have done a good job providing information that it is usually intimidating to clinicians.
Audience: This book is of use to all individuals interested in gene expression and the influence of the environment on gene behavior. It is of extreme importance for medical genetics specialists who seek further understanding of the etiology of genetics disorders, and it provides information to aid the in understanding of diagnostic genomic results. In addition, teachers of genetics may find this book useful for incorporating epigenetic information into high school, undergraduate, and graduate level courses.
Features: The 11 chapters cover topics from basic concepts and definitions to current controversies in epigenetics. Topics have been carefully selected and the book appears to be all inclusive. Early chapters cover basic concepts in generational epigenetics, but the book quickly delves deeper, reviewing concepts such as the emergence of phenotypic novelties during evolution by inheritance of epigenome variants across generations. The final chapter presents provocative and stimulating information about current controversies in generational epigenetic inheritance. The illustrations are appropriate and well designed.
Assessment: Usually epigenetics is covered in a chapter in books on human genetics. This book is unique in its focus solely on this subject. This is an area destined to become extremely important in the practice of human and medical genetics. This book is without comparison.
From the Publisher
"This book is unique in its focus solely on this subject. This is an area destined to become extremely important in the practice of human and medical genetics. This book is without comparison. Score: 99 - 5 Stars"—Doodys.com, January 23, 2015

"...this seminal book on transgenerational epigenetics not only confronts these controversies, but also illuminates many other aspects of transgenerational epigenetics."—Anticancer Research, January 2015

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Product Details

  • ISBN-13: 9780124059221
  • Publisher: Elsevier Science
  • Publication date: 5/2/2014
  • Sold by: Barnes & Noble
  • Format: eBook
  • Pages: 412
  • File size: 13 MB
  • Note: This product may take a few minutes to download.

Meet the Author

Professor of Biology, University of Alabama at Birmingham, Birmingham, AL. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. The Glenn Foundation for Medical Research funding was unsolicited and was awarded to Dr. Tollefsbol for lifetime contributions to the field of aging. In 2006 Dr. Tollefsbol was selected and highlighted as part of the 25th anniversary of the AFAR for significant contributions to aging research. Dr. Tollefsbol’s research interests have covered a wide range of topics such as aging, epigenetics, nutrition, cancer, telomerase, and caloric restriction. Work from his laboratory has been featured in Women’s Health magazine, Shape magazine, and the AICR Newsletter and Dr. Tollefsbol has been a Scientist in the Spotlight in ScienceNow. Currently he serves as an Associate Editor for Frontiers in Epigenomics and is on the Editorial Boards of the international journals Open Longevity Science, Epigenetics of Diabetes and Obesity, Molecular Biotechnology and Clinical Epigenetics. He is also a contributing Editor of Lewin’s GENES X classic textbook. Over 25 of the publications from Dr. Tollefsbol’s laboratory have received national or international accolades such as best paper award, selection for press release by the journal editors and featured on the journal homepage. Dr. Tollefsbol has been invited to give presentations on his research in many countries including Germany, China, Italy, Switzerland, France and The Netherlands as well as at various leading institutions in the US such as Harvard Medical School, Tufts University and the University of California at San Francisco. His research has received considerable media attention both nationally and internationally through television, newspaper and radio venues and has been highlighted in eScience News and ScienceDaily. He has ten books which have been published or are in progress and a recent book on “Epigenetics of Aging” that Dr. Tollefsbol co-authored and edited was highlighted in Nature.
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Table of Contents

  1. Transgenerational Epigenetics
  2. Historical Perspective of Transgenerational Epigenetics
  3. Epidemiology of Transgenerational Epigenetics
  4. Metastable Epiallels
  5. Paramutations
  6. Epigenetic Silencing of Transgenes
  7. Epigenetic Inheritance of Repeat Sequences
  8. Histone-mediated Transgenerational Epigenetics
  9. Heritable Generational Effects Through RNA
  10. Animal Models of Transgenerational Epigenetic Effects
  11. Plant Models of Transgnerational Epigenetic Inheritance
  12. Transgenerational Epigenetic Effects in Plants
  13. Maternal Epigenetic Inheritance
  14. Paternal Epigenetic Inheritance
  15. Evolution of Transgenerational Epigenetic Inheritance
  16. Heritable Epigenetics Over Multiple Generations
  17. Maternal Stress Effects on Transgenerational Epigenetics
  18. Preimplantation Environment and Epigenetic Transgenerational Inheritance
  19. Transgenerational Epigenetic Inheritance and Human Disease
  20. Environmental Transgenerational Epigenetic Effects
  21. Transgenerational Epigenetics of Endocrine Disruptors
  22. Effects of Transgenerational Epigenetics on Longevity
  23. Transgenerational Epigenetic Effects of an Environmental Enrichment on Memory Formation
  24. Dietary Effects on Transgenerational Epigenetic Inheritance
  25. Clinical Applications of Transgenerational Epigenetics
  26. Transgenerational Epigenetics: Current Controversies
  27. Future Directions of Transgenerational Epigenetic Research
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