Transgenic and Knockout Models of Neuropsychiatric Disorders

by Gene S. Fisch (Editor), Jonathan Flint (Editor)

Overview

In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

Product Details

ISBN-13:	9781617376078
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/09/2010
Series:	Contemporary Clinical Neuroscience
Edition description:	Softcover reprint of hardcover 1st ed. 2006
Pages:	296
Product dimensions:	5.98(w) x 9.02(h) x 0.03(d)

Table of Contents

and Overview.- Transgenic and Knockout Models of Psychiatric Disorders.- Transgenic Mouse Models and Human Psychiatric Disease.- Transgenic and Knockout Mouse Models.- If Only They Could Talk.- Transgenic and Knockout Models of Neurocognitive Dysfunction.- Spinocerebellar Ataxia Type 1.- Mouse Models of Hereditary Mental Retardation.- How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders?.- Animal Models of Autism.- Transgenic and Knockout Models of Neuropsychiatric Dysfunction.- Genetic Mouse Models of Psychiatric Disorders.- Animal Models of Psychosis.- Animal Models of Anxiety.- Modeling Human Anxiety and Depression in Mutant Mice.- Mutant Mouse Models of Bipolar Disorder.

Editorial Reviews

Aus den Rezensionen:

"… Das vorliegende Buch versucht, den aktuellen Stand einer faszinierenden Entwicklung festzuhalten, und beleuchtet durch Aufsätze von international anerkannten Autoren verschiedene Aspekte des Einsatzes von transgenen Tiermodellen bei neuropsychiatrischen Krankheitsbildern. Der erste einführende Teil des Buches gibt einen Überblick über Geschichte und die Untersuchung von Tiermodellen bei neuropsychiatrischen Fragestellungen. … Insgesamt stellt dieses Buch eine überaus interessante und anregende Lektüre … und könnte dabei wichtige Anregungen zur translationalen Umsetzung von Forschungsinhalten … vermitteln."

(H. H. Jung, in: Schweizer Archiv für Neurologie und Psychiatrie, 2007, Vol. 158, Issue 2, S. 91)

From the Publisher