Transgenic and Knockout Models of Neuropsychiatric Disorders / Edition 1

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In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

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Editorial Reviews

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"… Das vorliegende Buch versucht, den aktuellen Stand einer faszinierenden Entwicklung festzuhalten, und beleuchtet durch Aufsätze von international anerkannten Autoren verschiedene Aspekte des Einsatzes von transgenen Tiermodellen bei neuropsychiatrischen Krankheitsbildern. Der erste einführende Teil des Buches gibt einen Überblick über Geschichte und die Untersuchung von Tiermodellen bei neuropsychiatrischen Fragestellungen. … Insgesamt stellt dieses Buch eine überaus interessante und anregende Lektüre … und könnte dabei wichtige Anregungen zur translationalen Umsetzung von Forschungsinhalten … vermitteln."

(H. H. Jung, in: Schweizer Archiv für Neurologie und Psychiatrie, 2007, Vol. 158, Issue 2, S. 91)

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Product Details

  • ISBN-13: 9781617376078
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/9/2010
  • Series: Contemporary Clinical Neuroscience Series
  • Edition description: Softcover reprint of hardcover 1st ed. 2006
  • Edition number: 1
  • Pages: 296
  • Product dimensions: 9.00 (w) x 6.00 (h) x 0.70 (d)

Table of Contents

Introduction and Overview

Transgenic and Knockout Models of Psychiatric Disorders: Introduction, History, and Assessment

Gene S. Fisch

Transgenic Mouse Models and Human Psychiatric Disease

Jonathan Flint

Transgenic and Knockout Mouse Models: The Problem of Language

Linda J. Hayes and Diana Delgado

If Only They Could Talk: Genetic Mouse Models for Psychiatric Disorders

Trevor Humby and Lawrence Wilkinson

Transgenic and Knockout Models of Neurocognitive Dysfunction

Spinocerebellar Ataxia Type 1: Lessons From Modeling a Movement Disease in Mice

Harry T. Orr

Mouse Models of Hereditary Mental Retardation

Hans Welzl, Patrizia D'Adamo, David P. Wolfer, and Hans-Peter Lipp

How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders?

Simon E. Fisher

Animal Models of Autism: Proposed Behavioral Paradigms and Biological Studies

Thomas Bourgeron, Stéphane Jamain, and Sylvie Granon

Transgenic and Knockout Models of Neuropsychiatric Dysfunction

Genetic Mouse Models of Psychiatric Disorders: Advantages, Limitations, and Challenges

Joseph A. Gogos and Maria Karayiorgou

Animal Models of Psychosis

Stephen I. Deutsch, Katrice Long, Richard B. Rosse, Yousef Tizabi, Ronit Weizman, Judy Eller, and John Mastropaolo

Animal Models of Anxiety: The Ethological Perspective

Robert Gerlai, Robert Blanchard, and Caroline Blanchard

Modeling Human Anxiety and Depression in Mutant Mice

Andrew Holmes and John F. Cryan

Mutant Mouse Models of Bipolar Disorder: Are There Any?

Anneloes Dirks, Lucianne Groenink, and Berend Olivier


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