Transgenics in Endocrinology / Edition 1
  • Transgenics in Endocrinology / Edition 1
  • Transgenics in Endocrinology / Edition 1

Transgenics in Endocrinology / Edition 1

by Martin Matzuk
     
 

ISBN-10: 0896037649

ISBN-13: 9780896037649

Pub. Date: 06/01/2001

Publisher: Springer-Verlag New York, LLC

respective fields who have used creative approaches to better understa nd the complex processes that are characteristic of hormonal systems. This volume is a comprehensive review of topics in endocrinology, whic h has as its unifying theme the use of powerful transgenic mouse techn ology to better understand the endocrine physiology of living systems. Transgenic

…  See more details below

Overview

respective fields who have used creative approaches to better understa nd the complex processes that are characteristic of hormonal systems. This volume is a comprehensive review of topics in endocrinology, whic h has as its unifying theme the use of powerful transgenic mouse techn ology to better understand the endocrine physiology of living systems. Transgenic mouse technology has added tremendously to our understandi ng of hormone function in vivo. This work is a compendium of advances from a comprehensive group of systems in endocrinology whose common th eme is the use of this powerful technology. The reviews contained with in familiarize the reader with the most recent developments and serve as a basis for further discovery with a goal to advance the field of e ndocrinology. Furthermore the described mouse models will help to fost er new strategies for the evaluation and treatment of human disease. T his text will benefit graduate students, reproductive biologists, endo crinologists (both scientists and clinicians), and other scientists th at desire a comprehensive review of the subject material).

Read More

Product Details

ISBN-13:
9780896037649
Publisher:
Springer-Verlag New York, LLC
Publication date:
06/01/2001
Series:
Contemporary Endocrinology Series
Edition description:
2001
Pages:
486
Product dimensions:
7.01(w) x 10.00(h) x 0.04(d)

Table of Contents

Preface
Contributors
1Germline Genetic Engineering Techniques in Endocrinology1
2The Transgenic Mouse in Studies of Mammalian Sexual Differentiation19
3The In Vivo Function of Mullerian-Inhibiting Substance During Mammalian Sexual Development41
4Control of Ovarian Function61
5Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression91
6Functional Analysis of the Bcl2 Gene Family in Transgenic Mice115
7The Role of C-Kit/Kit Ligand Axis in Mammalian Gametogenesis147
8Gene Knockout Approaches to Steroidogenesis165
9The Progesterone Receptor Knockout Mouse Model: New Insights into Progesterone Action In Vivo173
10Knockout and Transgenic Mouse Models that Have Contributed to the Understanding of Normal Mammary Gland Development205
11Prolactin and the Prolactin Receptor231
12Transgenic Models for Oxytocin and Vasopressin245
13Glycoprotein Hormones: Transgenic Mice as Tools to Study Regulation and Function261
14Genetic Approaches to the Study of Pituitary Follicle-Stimulating Hormone Regulation297
15Transgenic Analysis of the Proopiomelanocortin Neuroendocrine System319
16Overexpression and Targeted Disruption of Genes Involved in the Control of Growth, Food Intake, and Obesity339
17Insulin and Insulin-Like Growth Factors: Targeted Deletion of the Ligands and Receptors371
18Use of Transgenic Animals in Skeleton Biology385
19Transgenic Mouse Models of Prostate Cancer401
20Neural- and Endocrine-Cell Specific Immortalization Using Transgenic Approaches427
Index469

Read More

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >