Transgenics in Endocrinology / Edition 1

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respective fields who have used creative approaches to better understa nd the complex processes that are characteristic of hormonal systems. This volume is a comprehensive review of topics in endocrinology, whic h has as its unifying theme the use of powerful transgenic mouse techn ology to better understand the endocrine physiology of living systems. Transgenic mouse technology has added tremendously to our understandi ng of hormone function in vivo. This work is a compendium of advances from a comprehensive group of systems in endocrinology whose common th eme is the use of this powerful technology. The reviews contained with in familiarize the reader with the most recent developments and serve as a basis for further discovery with a goal to advance the field of e ndocrinology. Furthermore the described mouse models will help to fost er new strategies for the evaluation and treatment of human disease. T his text will benefit graduate students, reproductive biologists, endo crinologists (both scientists and clinicians), and other scientists th at desire a comprehensive review of the subject material).

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Editorial Reviews

Doody's Review Service
Reviewer: Roy E. Weiss, MD, PhD (University of Chicago Medical Center)
Description: This book in the Contemporary Endocrinology series contains reviews by experts in the field of the current knowledge on transgenic and knock out animals and what they have taught us about endocrine systems.
Purpose: Development of embryonic stem cells of the mouse opened the door for the use of this animal in understanding hormonal regulation as well as a model for human disease. Although there has been a virtual explosion of research in this area over the last 10 years, there has not been a single book that brings together all the information in the field of endocrinology. While transgenic reviews have been written and made part of a particular subarea of endocrinology, such as thyroid or diabetes or reproduction, there is a worthy objective in bringing all the subareas together in one book. The three editors have done a wonderful job in getting experts in the field to review their respective areas for publication in one book.
Audience: The title may imply this could be a laboratory manual. Actually it is not intended to be a practical "how to" book, but indeed is much more encylopedic and original. The authors of the individual chapters put together the information learned from their different animal models. Basic scientists in endocrinology will find this an important book as it puts together in one book areas that they might not otherwise be able to find summarized so well. Clinical scientists and clinicians will welcome the book for the insights into endocrine mechanisms.
Features: The book is divided into 20 chapters. The first chapter is perhaps the most technical, but it is an extremely well written review on techniques involved in germline genetic engineering with instructive diagrams. Some of the other 19 chapters discuss specific genes, such as Bc12 gene family, prolactin, oxytocine, and vasopressin. Other chapters are more system-oriented, focusing on such topics as control of ovarian function or skeletal biology or obesity. The index is very helpful as a resource to determine if a particular hormone or factor has been discussed in the book. Although it does not detract from the book's usefulness, a section on diabetes is missing.
Assessment: This month another book covering similar topics, Transgenic Models in Endocrinology edited by Maria Castro (Kluwer Academic Publishers, 2001) has appeared. The Castro book is also excellent but less encyclopedic than this one. Although some of the topics are covered in both books, they are presented with a different perspective. Castro has chapters on POMC and CRF which are not in Matzuk et al. On the other hand, Matzuk et al. has chapters on prostate cancer, breast development, and the skeleton that are not in the Castro. While the Matzuk et al. is primarily by authors in Houston, Castro's book has a more international author list. Both books are very good and both are similar in content. If I wanted a broader, more inclusive book, I would choose the Matzuk and if I wanted a book with more of a neuroendocrine slant, I would consider Castro.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780896037649
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 6/1/2001
  • Series: Contemporary Endocrinology Series
  • Edition description: 2001
  • Edition number: 1
  • Pages: 486
  • Product dimensions: 6.96 (w) x 11.08 (h) x 1.12 (d)

Table of Contents

1 Germline Genetic Engineering Techniques in Endocrinology 1
2 The Transgenic Mouse in Studies of Mammalian Sexual Differentiation 19
3 The In Vivo Function of Mullerian-Inhibiting Substance During Mammalian Sexual Development 41
4 Control of Ovarian Function 61
5 Mouse Models to Study the Pituitary-Testis Interplay Leading to Regulated Gene Expression 91
6 Functional Analysis of the Bcl2 Gene Family in Transgenic Mice 115
7 The Role of C-Kit/Kit Ligand Axis in Mammalian Gametogenesis 147
8 Gene Knockout Approaches to Steroidogenesis 165
9 The Progesterone Receptor Knockout Mouse Model: New Insights into Progesterone Action In Vivo 173
10 Knockout and Transgenic Mouse Models that Have Contributed to the Understanding of Normal Mammary Gland Development 205
11 Prolactin and the Prolactin Receptor 231
12 Transgenic Models for Oxytocin and Vasopressin 245
13 Glycoprotein Hormones: Transgenic Mice as Tools to Study Regulation and Function 261
14 Genetic Approaches to the Study of Pituitary Follicle-Stimulating Hormone Regulation 297
15 Transgenic Analysis of the Proopiomelanocortin Neuroendocrine System 319
16 Overexpression and Targeted Disruption of Genes Involved in the Control of Growth, Food Intake, and Obesity 339
17 Insulin and Insulin-Like Growth Factors: Targeted Deletion of the Ligands and Receptors 371
18 Use of Transgenic Animals in Skeleton Biology 385
19 Transgenic Mouse Models of Prostate Cancer 401
20 Neural- and Endocrine-Cell Specific Immortalization Using Transgenic Approaches 427
Index 469
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