Translational Medicine: Strategies and Statistical Methods

Translational Medicine: Strategies and Statistical Methods

by Dennis Cosmatos, Shein Chung-Chow
     
 

ISBN-10: 1584888725

ISBN-13: 9781584888727

Pub. Date: 12/17/2008

Publisher: Taylor & Francis

Examines Critical Decisions for Transitioning Lab Science to a Clinical Setting
The development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in the

Overview

Examines Critical Decisions for Transitioning Lab Science to a Clinical Setting
The development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in the healthcare industry – a means of maximizing the consideration and use of information collected as compounds transition from initial lab discovery, through pre-clinical testing, early clinical trials, and late confirmatory studies that lead to regulatory approval of drug release to patients.

Translational Medicine: Strategies and Statistical Methods suggests a process for transitioning from the initial lab discovery to the patient’s bedside with minimal disconnect and offers a comprehensive review of statistical design and methodology commonly employed in this bench-to-bedside research.

Documents Alternative Research Approaches for Faster and More Accurate Data Judgment Calls
Elaborating on how to introduce TM into clinical studies, this authoritative work presents a keen approach to building, executing, and validating statistical models that consider data from various phases of development. It also delineates a truly translational example to help bolster understanding of discussed concepts.

This comprehensive guide effectively demonstrates how to overcome obstacles related to successful TM practice. It contains invaluable information for pharmaceutical scientists, research executives, clinicians, and biostatisticians looking to expedite successful implementation of this important process.

Product Details

ISBN-13:
9781584888727
Publisher:
Taylor & Francis
Publication date:
12/17/2008
Series:
Chapman & Hall/CRC Biostatistics Series, #28
Pages:
224
Product dimensions:
6.30(w) x 9.40(h) x 0.70(d)

Table of Contents

Translational Medicine: Strategies and Statistical Methods, D. Cosmatos and S.-C. Chow

Strategic Concepts in Translational Medicine, D. Cosmatos and G. Feuerstein

Design and Analysis Approaches for Discovery Translational Medicine, D. Cosmatos, S.-C. Chow, S.B. Forlow, J.A. Isler, Z. Lin, and M.E. Burczynski, with a special statistical appendix by J.Q. Xia and S.S. Young

Biomarker Development, M. Chang

Targeted Clinical Trials, J. Liu

Statistical Methods in Translational Medicine, S.-C. Chow, S.-K. Tse, and D. Cosmatos

NonparametricMethods in Translational Research, K. Wang and S.-C. Chow

Model Selection/Validation, J. Liu

Translation in Clinical Information between Populations—Bridging Studies, C.-F. Hsiao, M. Wang, H.-D. Chen, and J. Liu

Translation in Clinical Technology—Traditional Chinese Medicine, C.-F. Hsiao, H.-H. Tsou, and S.-C. Chow

Index

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