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Transmembrane Dynamics of Lipids is comprised of contributions from expert authors from leading research groups that present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes.
Incorporating an impressive amount of new, previously uncollected data, the book examines transmembrane asymmetry and movement of lipids in biological membranes, and methods for the measurement of transmembrane lipid motion, emphasizing the role of lipid flippases and discusses biological functions associated with lipid asymmetry. In addition, it draws attention to important new discoveries in the field, such as the correlation between malfunction of lipid flippases and human diseases such as thrombosis and cancer. The book also addresses the manifold methods that are used to measure the rate of transmembrane movement of lipids in biological and model systems.
The only guide to new discoveries regarding lipids in cell membranes, Transmembrane Dynamics of Lipids is designed to appeal to biophysicists, biochemists, and cellular and molecular biologists working in the growing field of membrane research.
Part 1. Assessment Transmembrane Movement and Asymmetry of Lipids.
1. Methods for the determination of lipids transmembrane distribution and movement in biological membranes (Andreas Herrmann and Philippe F. Devanx).
2. Detection and measurement of unlabelled lipid transmembrane movement (Iván López-Montero, Marisela Vélez and Philippe F. Devaux).
Part 2. Lipid Assmetry in Cell Membranes.
3. New insights in membrane lipid asymmetry in animal and plant cells (Alain Zachowski).
4. Sphingolipid asymmetry and transmembrane translocation in mammalian cells (Gerrit can Meer, Sylvia Neumann and Per Haberkant).
5. Transbilayer movement and distribution of cholesterol (Peter Müller, Anna Pia Plazzo, and Andreas Herrmann).
Part 3. Energy Independent Protein-Mediated Transmembrane Movement of Lipids.
6. Phospholipid flip-flop in biogenic membranes (Andreas Herrmann and Anant K. Menon).
7. Phospholipid Scramblase – When phospholipid asymmetry goes away (Edouard M. Bevers and Patrick L. Williamson).
Part 4. Energy dependent Lipid Transport across Membranes.
8. Flip or flop: mechanism and (patho)physiology of P4-ATPase-catalysed lipid transport (Patricia M. Verhulst, Thomas G. Pomorski and Joost C. M. Holthuis).
9. Coupling Drs2p to phospholipid translocation, membrane asymmetry and vesicle budding (Xiaoming Zhou, Ke Liu, Paramasivam Natarajan, Baby-Periyanayaki Muthusamy and Todd R. Graham).
10. Substrate specificity of the aminophospholipid flippase (Shelley M. Cook and David L. Daleke).
Overview
Transmembrane Dynamics of Lipids is comprised of contributions from expert authors from leading research groups that present up-to-date quantitative data on the formation, stability, and biological consequences of the asymmetrical organization of lipids in cell membranes.
Incorporating an impressive amount of new, previously uncollected data, ...