Transmissible Diseases and Transfusion / Edition 1

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Overview

This book is the only published literature that comprehensively discusses all aspects of transfusion of transmissible diseases, the facts and the fiction. It is of paramount importance to all involved in the vein to vein chain of transfusion medicine.

Session I addresses the basic blood safety aspects including the need for quality management, rational donor screening and the risks of blood transfusion for prenatal developmental toxicity.

Session II addresses the gamma of transmissible infectious agents from bacteria through parasites and tick-borne agents to prions and the risks associated with xeno-transplantation and xenozoonoses

Session III sheds new light on NAT technology for detection of viral DNA and RNA, the cost-effectiveness of the alternatives to allogeneic blood transfusion. To what extent are genetic defects in stem cell genomic structures transmissible through transplantation and does questioning potential donors make any sense?

Session IV addresses the preventive aspects on the future of transfusion medicine. Quantitative real-time PCR for Parvo B19 and advances in bacterial detection technology. The advancement from theory to practice of pathogen inactivation technology based on destruction of nucleic acids in cellular structures. Finally, a plea is made for co-operation and collaboration on a global scale, changing the pars pro toto phenomenon (the ships that pass in the night) for a totum pro parte, a true joining of forces to create a global network for blood safety and structured blood supply systems.

Transmissible Diseases and Blood Transfusion is an important reference for all hematologists and researchers involved in transfusion medicine.

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Product Details

Table of Contents

Moderators and Speakers
Foreword
I Blood Safety Aspects
Germs, Gels and Genomes. A Personal Recollection of 30 Years in Blood Safety Testing 3
Quality Management for Blood Transfusion Services 21
The Value of Donor Selection for Blood Safety 23
Blood Donation: A Risk for Prenatal Developmental Toxicity? 25
II Transmissible Diseases
Bacterial Contamination of Blood and Blood Products. An Underestimated Problem 51
Parasites Transmitted by Blood Transfusion 57
Prion Diseases and Blood Transfusion 73
Tick-Borne Diseases: Recognized and Theoretical Risks Associated with Blood Transfusion 83
Xeno-Transplantation and Xenozoonoses 93
III Transmissible Diseases
NAT Update: Where Are We Today? 111
Cost-Effectiveness of Alternatives to Allogeneic Blood Transfusion; Reviewing the Available Evidence 131
Hereditary Metabolic Diseases and Stem Cell Transplantation 143
Detection of Disease: Possibilities and Limitations 147
IV Preventative Aspects
Quantitative Real-Time PCR for Detection of Parvovirus B19 DNA in Blood Plasma for Plasma Screening 167
Advances in Bacterial Detection Technology 177
Pathogen Inactivated Blood Components: Advancing from Theory to Practice 181
GCBS, ICBS and Other Initiatives - The Pars Pro Toto Phenomenon; Will There Ever Be a Totum Pro Parte? 195
Index 213
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