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This book is the only published literature that comprehensively discusses all aspects of transfusion of transmissible diseases, the facts and the fiction. It is of paramount importance to all involved in the vein to vein chain of transfusion medicine.
Session I addresses the basic blood safety aspects including the need for quality management, rational donor screening and the risks of blood transfusion for prenatal developmental toxicity.
Session II addresses the gamma of transmissible infectious agents from bacteria through parasites and tick-borne agents to prions and the risks associated with xeno-transplantation and xenozoonoses
Session III sheds new light on NAT technology for detection of viral DNA and RNA, the cost-effectiveness of the alternatives to allogeneic blood transfusion. To what extent are genetic defects in stem cell genomic structures transmissible through transplantation and does questioning potential donors make any sense?
Session IV addresses the preventive aspects on the future of transfusion medicine. Quantitative real-time PCR for Parvo B19 and advances in bacterial detection technology. The advancement from theory to practice of pathogen inactivation technology based on destruction of nucleic acids in cellular structures. Finally, a plea is made for co-operation and collaboration on a global scale, changing the pars pro toto phenomenon (the ships that pass in the night) for a totum pro parte, a true joining of forces to create a global network for blood safety and structured blood supply systems.
Transmissible Diseases and Blood Transfusion is an important reference for all hematologists and researchers involved in transfusion medicine.
|Moderators and Speakers|
|I||Blood Safety Aspects|
|Germs, Gels and Genomes. A Personal Recollection of 30 Years in Blood Safety Testing||3|
|Quality Management for Blood Transfusion Services||21|
|The Value of Donor Selection for Blood Safety||23|
|Blood Donation: A Risk for Prenatal Developmental Toxicity?||25|
|Bacterial Contamination of Blood and Blood Products. An Underestimated Problem||51|
|Parasites Transmitted by Blood Transfusion||57|
|Prion Diseases and Blood Transfusion||73|
|Tick-Borne Diseases: Recognized and Theoretical Risks Associated with Blood Transfusion||83|
|Xeno-Transplantation and Xenozoonoses||93|
|NAT Update: Where Are We Today?||111|
|Cost-Effectiveness of Alternatives to Allogeneic Blood Transfusion; Reviewing the Available Evidence||131|
|Hereditary Metabolic Diseases and Stem Cell Transplantation||143|
|Detection of Disease: Possibilities and Limitations||147|
|Quantitative Real-Time PCR for Detection of Parvovirus B19 DNA in Blood Plasma for Plasma Screening||167|
|Advances in Bacterial Detection Technology||177|
|Pathogen Inactivated Blood Components: Advancing from Theory to Practice||181|
|GCBS, ICBS and Other Initiatives - The Pars Pro Toto Phenomenon; Will There Ever Be a Totum Pro Parte?||195|