Transporters as Drug Carriers: Structure, Function, Substrates / Edition 1

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This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion.
As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general.
For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

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Editorial Reviews

From the Publisher
"Overall, the book is well organized and the topics are clearly andeasily accessible. This book offers many strengths ...but overallis quite worthwhile." (ChemMedChem, January 2011)

"Overall, the book is a specialised text (as reflected in theprice) that provides a comprehensive review of drug transporters.It would also be a welcome addition to any well stocked universitylibrary." (PJ Online, 12 November 2010)

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Product Details

Meet the Author

Gerhard Ecker is the head of the Pharmacoinformatics Initiative atthe Department of Medicinal Chemistry, University of Vienna. Hestudied Pharmacy at the University of Vienna (Ph.D. thesisadvisors: W. Fleischhacker and C.R. Noe) and did post-doctoral workwith J. Seydel in Borstel (Germany) where he started his SAR andQSAR studies on P-glycoprotein. His main scientific interests arepharmacoinformatic approaches to target drug efflux pumps, insilico screening methods for promiscuous targets, and non-linearmethods in drug design.

Peter Chiba is a senior scientist and lecturer at the MedicalUniversity of Vienna. He holds a doctorate in Medicine from theUniversity of Vienna and worked at the Universities of Nijmegen(The Netherlands) and South Florida (USA) as a Fulbright scholarand post-doctoral associate. His research focuses on multidrugtransport and resistance to drugs in treatment of cancer andmicrobial disease.

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Table of Contents

1 The ABC Transporters: Structural Insights into DrugTransport
2 Biochemistry, Physiology, and Pharmacology of Nucleoside andNucleobase Transporters
3 Organic Anion Transporting Polypeptides (Oatps/OATPs)
4 CNS Transporters as Drug Targets
5 Bacterial Multidrug Transporters: Molecular and ClinicalAspects
6 Pleiotropic drug resistance in yeast and fungal pathogens
7 QSAR studies on ABC-transporters: how to deal withpolyspecificity
8 Drug Transporter Pharmacophores
9 Biological Membranes and Drug Transport
10 Transport at the Blood-Brain Barrier
11 Bile canalicular transporters
12 Interplay of Cytochrome P450 Isoenzymes andABC-transporter
13 ABC-Transporter: From target to antitarget
14 A Systems Biology View of Drug Transporters
15 Drug Transporters in Health and Disease

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