Treating Dementia: Do We Have a Pill for It?

Overview

Treatments for age-related dementia and the growing reliance on pharmaceuticals to alleviate its worst symptoms raise a number of questions about attitudes toward aging and cognition, the relationship between growing older and getting sick, and the conflicting interests of patients, caregivers, physicians, scientists, and business. This volume aims to foster a constructive debate about the future of dementia treatment by providing multiple perspectives on these tangled issues.

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Overview

Treatments for age-related dementia and the growing reliance on pharmaceuticals to alleviate its worst symptoms raise a number of questions about attitudes toward aging and cognition, the relationship between growing older and getting sick, and the conflicting interests of patients, caregivers, physicians, scientists, and business. This volume aims to foster a constructive debate about the future of dementia treatment by providing multiple perspectives on these tangled issues.

The first section examines how the concepts of dementia have expanded to encompass a broad range of symptoms and the implications of this evolution on the development of pharmaceutical treatments. The second section explores the use and effectiveness of drug treatments for dementia through the perspectives of a clinician, a researcher, and a layperson. In the third section, the contributors probe how culture, language, and values affect the overlapping worlds of pharmacology, drug marketing, and dementia treatment. A final section elucidates the thorny ethical and policy concerns surrounding the often-conflicting hopes for dementia medications.

Featuring contributions from noted clinicians, researchers, and scholars from a broad range of disciplines, this multidisciplinary dialogue addresses central questions about the history and future of drug treatment for dementia and makes clear why there are no simple answers. Professionals and students involved in gerontology, psychiatry, and bioethics will find the discussion both enlightening and practical.

Johns Hopkins University Press

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Editorial Reviews

JAMA

An interdisciplinary analysis of the development of drugs for Alzheimer disease. Alongside and intertwined with the theme of drug development is thorough scrutiny of the concepts of Alzheimer disease and dementia from a wealth of viewpoints.

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Product Details

  • ISBN-13: 9780801893650
  • Publisher: Johns Hopkins University Press
  • Publication date: 9/2/2009
  • Pages: 288
  • Product dimensions: 6.10 (w) x 9.00 (h) x 1.00 (d)

Meet the Author

Jesse F. Ballenger, Ph.D., is an assistant professor in the Science, Technology, and Society Program at Pennsylvania State University. Peter J. Whitehouse, M.D., Ph.D., is the director of integrative studies at Case Western Reserve University. Constantine G. Lyketsos, M.D., M.H.S., is the Elizabeth Plank Althouse Professor in Alzheimer's Disease Research at Johns Hopkins, where he is chair of the Department of Psychiatry at the Bayview Medical Center, vice-chair of the Department of Psychiatry and Behavioral Sciences at the Johns Hopkins Hospital, co-director of the Division of Geriatric Psychiatry and Neuropsychiatry, and director of the Memory and Alzheimer's Treatment Center. Peter V. Rabins, M.D., M.P.H., is the vice-chair for Faculty Academic Affairs at the Johns Hopkins University, where he is co-director of the Division of Geriatric Psychiatry and Neuropsychiatry and a professor of psychiatry and behavioral sciences. Jason H. T. Karlawish, M.D., is an associate professor of medicine and medical ethics at the University of Pennsylvania.

Johns Hopkins University Press

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Table of Contents

Pt. I Concepts of Dementia and Treatment 1

1 The Classification of Alzheimer's Disease and Mild Cognitive Impairment: Enriching Therapeutic Models through Moral Imagination Danny George George, Danny Peter J. Whitehouse Whitehouse, Peter J. 5

2 Notes toward a Future History of Treatments for Cognitive Failure David Healy Healy, David 25

3 Alzheimer's Disease: Pathogenesis, Models, and Experimental Therapeutics Donald L. Price Price, Donald L. Tong Li Tong, Li Fiona M. Laird Laird, Fiona M. Mohamed H. Farah Farah, Mohamed H. Alena V. Savonenko Savonenko, Alena V. Vassilis E. Koliatsos Koliatsos, Vassilis E. Juan C. Troncoso Troncoso, Juan C. Philip C. Wong Wong, Philip C. 42

4 From the Periphery to the Center: Treating Noncognitive, Especially Behavioral and Psychological, Symptoms of Dementia Annette Leibing Leibing, Annette 74

Pt. II The Use and Evaluation of Drugs for Dementia 99

5 Pharmacologic Treatment of Dementia: A Clinician's View Allan A. Anderson Anderson, Allan A. 103

6 Managing Dad Judith Levine Levine, Judith 116

7 Making Sense of the Language of Benefit for Alzheimer's Disease Treatments Jason H. T. Karlawish Karlawish, Jason H. T. 125

Pt. III Objectivity, Language, and Values at the Interface of Science, Medicine, and Business 133

8 Science and Marketing: The Promotion of Donepezil in the Primary Research Literature John R. Gilstad Gilstad, John R. Thomas E. Finucane Finucane, Thomas E. 137

9 Profiling Drugs and Diseases: The Shaping, Making, and Marketing of Drugs for Alzheimer's Disease Rein Vos Vos, Rein 147

10 Can We Fix This with a Pill? Qualities of Life and the Aging Brain Peter J. Whitehouse Whitehouse, Peter J.168

Pt. IV The Problem of Hope 183

11 Necessary Inventions: Antidementia Drugs and Heightened Expectations for Aging in Modern American Culture and Society Jesse E. Ballenger Ballenger, Jesse E. 189

12 Truth and Hope in Drug Development and Evaluation in Alzheimer's Disease Tiago Moreira Moreira, Tiago 210

13 APOE Genotyping, Risk Estimates, and Public Understanding of Susceptibility Genes Margaret Lock Lock, Margaret Adam Hedgecoe Hedgecoe, Adam 231

14 Developing Drugs for Dementia: Hope, Hype, and Hypocrisy Peter V. Rabins Rabins, Peter V. 250

Index 259

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