Treating Infectious Diseases in a Microbial World:: Report of Two Workshops on Novel Antimicrobial Therapeutics

Treating Infectious Diseases in a Microbial World:: Report of Two Workshops on Novel Antimicrobial Therapeutics

by Committee on New Directions in the Study of Antimicrobial Therapeutics: New Classes of Antimicrobials, Committee on New Directions in the Study of Antimicrobial Therapeutics: Immunomodulation, National Research Council
     
 

ISBN-10: 0309100569

ISBN-13: 9780309100564

Pub. Date: 01/03/2006

Publisher: National Academies Press

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of

Overview

Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Product Details

ISBN-13:
9780309100564
Publisher:
National Academies Press
Publication date:
01/03/2006
Pages:
103
Product dimensions:
8.50(w) x 11.00(h) x (d)

Table of Contents


Summary     1
Challenges for the Development of New Antimicrobials-Rethinking the Approaches: Report of a Workshop     7
Introduction     7
Antibiotic Resistance     10
A Microbial Community Approach to New Antibacterials     15
Understanding Biological Processes to Devise New Antibiotics     19
Need for New Molecules     25
How Can This Work Be Carried Out?     32
References     32
Promising Approaches to the Development of Immunomodulation for the Treatment of Infectious Diseases: Report of a Workshop     37
Introduction     37
Modulating Innate Immunity     43
Modulating Acquired Immunity     50
Taking Advantage of the Resident Microbiota     53
Cross-cutting Research Needs for the Development of Immunotherapy     57
The Near and Far Horizon     59
References     59
Appendixes
Statement of Task     63
New Classes of Antimicrobials Committee Biographical Sketches     65
New Classes of Antimicrobials Workshop     69
Immunomodulation Committee Biographical Sketches     79
Immunomodulation Workshop     85

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