The Treatment of Epilepsy / Edition 3

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A practical reference to the medical and surgical treatment of epilepsy

The third edition of The Treatment of Epilepsy has been thoroughly updated. It is a reference work, but has a strong practical bias, and is designed to assist neurologists, neurosurgeons and other clinicians at all levels who are involved in the treatment of patients with epilepsy. It is a definitive source of clinical information to guide clinical practice and rational therapy.

Written and edited by leading experts, many actively involved with the International League Against Epilepsy, this new edition:

  • covers the recent advances in the principles and approaches to epilepsy therapy, the introduction of new drugs and the development of new surgical techniques
  • contains 26 completely new chapters and 61 new contributors
  • includes pharmacological properties and prescribing information for all drugs used in the treatment of epilepsy
  • features the important contribution of a new editor Jerome Engel Jr, Professor of Neurology at the University of California School of Medicine in Los Angeles.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

From the Publisher
"I would highly recommend The Treatment of Epilepsy for neurologists, neurosurgeons, psychiatrists, pediatricians, and internists, as well as nurse practitioners, physician's assistants, and others who are interested in delving into the details of the treatment of epilepsy ." (Epilepsy & Behavior, 6 October 2010)
Doody's Review Service
Reviewer: Jennifer L Hopp, MD (University of Maryland School of Medicine)
Description: This is the second edition of an extremely comprehensive review of the medical and surgical treatments of the epilepsies that includes a detailed review of the literature as well as practical summaries of the current available treatments for the practicing physician. The book is unique in that it provides a review of these treatments using current themes in the treatment of epilepsy and neurologic disease, such as genetic and surgical advances in the field as well as an update on the newer anticonvulsants. The previous edition was published in 1996.
Purpose: The author notes that this book, and specifically the updated edition, has several goals, the clearest of which is to provide a systematic and thorough review of current medical and surgical treatments of the epilepsies using both practical and evidence-based approaches. These objectives are valuable, particularly as the advances in the therapies in the field of epilepsy have changed significantly in the last decade, and the practice of medicine as a whole has shifted to include more of an evidence-based approach. He meets these objectives in a unique way, by weaving four themes of the book through the review of these advances in the treatment of epilepsy. He is able to incorporate the advances in molecular genetics in the review of drug therapy, discuss evidence-based practices in clinical protocols for the use of the newer anticonvulsants, examine investigational advances in epilepsy surgery, and finally, discuss several therapies using a patient-centered approach.
Audience: The editors as well as chapter authors are credible authorities in the specialty of epilepsy as well as in their respective subspecialties in the field. A unique aspect of the book is the international panel of chapter authors, which provides a global perspective on the treatment of epilepsy. The book is written with enough background and detail to provide an update for epileptologists, but is also a comprehensive summary for general neurologists, fellows, or residents. The chapters are organized with easy to read tables and bullet points which facilitate quick reference, as well as enough readable detail for a comprehensive review.
Features: This book provides a comprehensive review of the various epilepsies and general principles in treatment and subsequently embarks on a very detailed review of the medical and surgical treatment of the disease. Dr. Shorvon takes a unique approach, in weaving this information through the themes of molecular genetics, evidence-based clinical protocols, investigational advances in surgery, and treatment of patients using a patient-centered or psychosocial based approach. These themes provide a backdrop for the comprehensive review of the current and investigational treatments in use. The strongest features of the book include the international perspectives provided by the section authors, as well as the updates in investigational methods being employed by major epilepsy centers around the globe. Of note, there also is an interesting historical review of the disease which precedes the review of current treatments which sets the stage for the recent advances in the last century. The review of current anticonvulsant drugs is particularly well done, with intricate detail of drug mechanism, treatment paradigms, and unique sections covering such topics as pharmacoeconomic aspects and quality of life pertinent to comprehensive patient care. There are some new color plates in the section on new physiological and radiological investigations in the presurgical evaluation which provide a valuable resource to readers who may not be familiar with some of the advances in the field.
Assessment: This new edition presents a wonderful overview of the medical and surgical treatment of epilepsy which will provide a comprehensive resource for epileptologists in academic practice, fellows or residents in training, as well as neurologists in private practice. The unique features of the book, including the global perspectives provided by section authors and the focus on new advances such as molecular genetics and investigational approaches in the field, justify this new edition. In addition, the coverage of psychosocial, patient-centered, and economic perspectives is unique compared to other books in the field. There is similarity in this approach to the comprehensive three-volume book by Engel and Pedley, Epilepsy: A Comprehensive Textbook (Lippincott Williams & Wilkins, 1997), though this book serves a slightly different role in its treatment-centered focus. It will serve as a useful resource as well as a review tool for general neurologists as well as subspecialists.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781405183833
  • Publisher: Wiley
  • Publication date: 8/17/2009
  • Edition description: New Edition
  • Edition number: 3
  • Pages: 1116
  • Product dimensions: 9.10 (w) x 11.00 (h) x 2.20 (d)

Meet the Author

Professor Simon Shorvon, Institute of Neurology, Queen's Square, London, UK

Professor Emilio Perucca, University of Pavia, Italy

Professor Jerome 'Pete' Engel, University of California at Los Angeles, USA

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Table of Contents

Section 1 – Introduction

1. Definitions and Classification of Epilepsy, Christina A. Gurnett and W. Edwin Dodson

2. Epidemiology and Prognosis of Epilepsy, Lars Forsgren and Dale Hesdroffer

3. Aetiology of Epilepsy, Simon D. Shorvon

4. Differential Diagnosis of Epilepsy, Mark Cook

5. Mechanisms of Epileptogenesis, Giuliano Avanzini and Silvana Franceschetti

6. Antiepileptic Drug Discovery, Steve H. White

7. Mechanisms of Antiepileptic Drug Action, Matthew C. Walker, Rainer Surges and A. Fisher

8. Mechanisms of Tolerance and Drug Resistance, Wolfgang Löscher and Dieter Schmidt

Section 2 – Principles of Medical Management

9. General Principles of Medical Management, Emilio Perucca

10. Management of Newly Diagnosed Epilepsy, Yvonne M. Hart

11. Management of Chronic Active Epilepsy in Adults, Simon D. Shorvon

12. Management of Epilepsy in Remission, Patrick Kwan and Howan Leung

13. Management of Epilepsy in Infants, Catherine Chiron

14. Management of Childhood Epilepsy Syndromes, Colin D. Ferrie

15. Management of Epilepsies Associated with Specific Diseases in Children, John H. Livingston

16. Management of Epilepsy in the Elderly, Hiba Arif, Anil Mendiratta and Lawrence J. Hirsch

17. Management of Epilepsy in People with Learning Disabilities, Eylert Brodtkorb

18. Emergency Treatment of Seizures and Status Epilepticus, Matthew C. Walker and Simon D. Shorvon

19. Traumatic Brain Injury and Other Risks, Marc Dichter and Nancy R. Temkin

20. Management of Medical Co-morbidity Associated with Epilepsy, Gagandeep Singh

21. Psychiatric Features of Epilepsy and their Management, Brent Elliott, Meriem Amarouche and Simon D. Shorvon

22. Management of Side-effects of Antiepileptic Drugs, Gaetano Zaccara, Fabrizio Balestrieri and Aldo Ragazzoni

23. Ketogenic Diets, Eric H. Kossoff and Jennifer L. Dorward

24. Non-pharmacological, Complementary and Alternative Treatments for Epilepsy, Tom Whitmarsh

25. Reproductive Aspects of Epilepsy Treatment, Torbjörn Tomson

26. Epilepsy Counselling, Anthony Linklater, Doreen Patsika and Susan Usiskin

27. Genetic Counselling in Epilepsy, Federico Zara

28. Drug Interactions, Edoardo Spina

29. Medical Treatment of Epilepsy in Situations with Limited Resources, Gretchen L. Birbeck

Section 3 – Antiepileptic Drugs

30. Introduction to the Choice of Antiepileptic Drugs, Emilio Perucca

31. Acetazolamide, Miri Y. Neufeld

32. Adrenocorticotropic Hormone and Corticosteroids, Federico Vigevano and M. R. Cilio

33. Benzodiazepines used Primarily for Chronic Treatment (Clobazam, Clonazepam, Clorazepate and Nitrazepam), Peter Camfield and Carol Camfield

34. Benzodiazepines used Primarily for Emergency Treatment (Diazepam, Lorazepam and Midazolam), Eugen  Trinka

35. Brivaracetam, Philipp von Rosenstiel and Emilio Perucca

36. Carisbamate, Gerald P. Novak and Martin J. Brodie

37. Carbamazepine, Matti Sillanpää, Leena Haataja, T. Tomson and S.I. Johannessen

38. Eslicarbazepine Acetate, Patricio Soares-da-Silva, Luis Almeida and Meir Bialer

39. Ethosuximide, Tracy A. Glauser and Emilio Perucca

40. Felbamate, Ilo E. Leppik and J.R. White

41. Gabapentin, Ernest R. Somerville and Andrew W. Michell

42. Lacosamide, Rajesh Sachdeo

43. Lamotrigine, Fumisuke Matsuo and Awais Riaz

44. Levetiracetam, Jacqueline A. French and Francoise Tonner

45. Oxcarbazepine, Edward Faught and Nita Limdi

46. Phenobarbital, Primidone and Other Barbiturates, Roberto Michelucci, Elena Pasini and Carlo Alberto Tassinari

47. Phenytoin, Mervyn J. Eadie

48. Piracetam, Simon D. Shorvon

49. Pregabalin, Sylvain Rheims and Philippe Ryvlin

50. Retigabine, Harry Mansbach and Michel Baulac

51. Rufinamide, Victor Biton

52. Stiripentol, Kai Eriksson and Tapani Keränen

53. Tiagabine, Reetta Kälviäinen

54. Topiramate, J. Helen Cross and Kate J. Riney

55. Valproate, Blaise F.D. Bourgeois

56. Vigabatrin, Günter Krämer and Gabriele Wohlrab

57. Zonisamide, Stephen J. Wroe

58. Other Drugs Rarely Used, Hartmut Meierkord and M. Holtkamp

59. Antiepileptic Drugs in Early Clinical Development, Philip N. Patsalos and Josemir W. Sander

Section 4 – Presurgical Assessment and Epilepsy Surgery

60. Overview of Surgical Treatment for Epilepsy, Jerome Engel Jr

61. Scalp EEG in the Epilepsy Surgery Evaluation, John M. Stern and Christine M. Bower

62. Invasive EEG in Presurgical Evaluation of Epilepsy, Susan S. Spencer, Dang K. Nguyen and Robert B. Duckrow

63. MEG in Presurgical Evaluation of Epilepsy, Herman Stefan, S. Rampp and R. Hopfengärtner

64. MRI in the Presurgical Evaluation, Christian E. Elger and J. Wellmer

65. PET and SPECT in Presurgical Evaluation of Epilepsy, Wim Van Paesschen, Karolien Goffin and Koen Van Laere

66. Experimental Neurophysiological Techniques, François Mauguière, Isabelle Merlet and Julien Jung

67. Neuropsychological Testing in Presurgical Evaluation, Marilyn Jones-Gotman and Jelena Djordjevic

68. Presurgical Psychiatric Evaluation, Andres M. Kanner

69. Mesial Temporal Lobe Surgery and Other Lobar Resections, James Leiphart and Itzhak Fried

70. Resective Surgery of Neoplasms, N.M. Wetjen, Mithri R. Junna, K. Radhakrishnan, A.A. Cohen-Gadol and Gregory D. Cascino

71. Resective Surgery of Vascular and Infective Lesions for Epilepsy, Christopher E. Uff and Neil D. Kitchen

72. Surgery of Developmental Anomalies Causing Epilepsy, Youssef G. Comair and Joshua Chern

73. Hemispherectomy for Epilepsy, Olivier Delalande, Georg Dorfmüller, and Christine Bulteau

74. Corpus Callosotomy, David W. Roberts

75. Hypothalamic Hamartoma and Multiple Subpial Transection, Michael Smith, Rich Burne and Andres Kanner

76. Awake Surgery for Epilepsy, Christian B. Kaufman and Webster H. Pilcher

77. Epilepsy Surgery in Children, Jason S. Hauptman and Gary W. Mathern

78. Stereotactic Surgery for Epilepsy, Andrew W. McEvoy and Fiona J.L. Arnold

79. Complications of Epilepsy Surgery, Charles E. Polkey

80. Anaesthesia for Epilepsy Surgery, Barbara Van de Wiele

81. Vagal Nerve Stimulation, Steven C. Schachter

82. Brain Stimulation, Gregory K. Bergey

83. Stereotactic Radiosurgery for Medically Intractable Epilepsy, Isaac Yang, Edward F. Chang and Nicholas M. Barbaro

84. Future Focal Treatment Approaches to Epilepsy, Hannah R. Cock and Karen E. Nilsen

85. Epilepsy Surgery in Countries with Limited Resources, Andre Palmini

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