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Doody's Review ServiceReviewer: Muhammad Rafi Ud Din, MD (University of Kentucky College of Medicine)
Description: Appearing 12 years after the first edition, this revised, second edition of a book on glomerulonephritis keeps the same format of multiple short chapters.
Purpose: The goals are to offer comprehensive information and detailed discussion on the rationale, specifics, efficacy, toxicity, and limitations of current therapy as there has been tremendous development in the area of immune-modulating treatment options for various forms of primary glomerulonephritis since the last edition. This book responds well to the continued need for updated, well-organized information in this area where most guidelines and recommendations are still based on opinion.
Audience: It is written primarily for nephrology and glomerular disease specialists, as well as general internists and trainees caring for patients with primary glomerular diseases. A fresh view is being offered by a large number of international authors (authorities in their fields) and the newly assigned section editors.
Features: The book uses a standard design of black-and-white print with a colorful atlas in the middle to describe salient features of different primary glomerulonephritis with some immunofluorescence and electron micrographs. It provides a brief introduction to pathogenesis, etiology, epidemiology, and clinical presentation of glomerular diseases. It then details medical management, based on a critical review of the best available randomized clinical trials. In controversial areas, or the ones lacking definitive clinical studies, the authors provide their personal views and approach to treatment. Also, the first three chapters of the book describe the symptomatic therapy, pharmacology of glucocorticoids, and newer immune-modulating agents. The last chapter covers the less common form of glomerular diseases and recurrent glomerular diseases in the transplanted kidney. It provides diagnostic and treatment algorithms and tables of commonly used drugs. There are plenty of updated references, but placing them in the middle of sentences is rather distracting. The index is good but not complete. There are a few new topics, including transplant immunology and immunosuppression.
Assessment: This is an excellent addition to the currently available publications on medical management of glomerular diseases. It has its own niche because it offers in-depth discussions, critiques, and referenced coverage of key trials that influence decision making. It is rather comprehensive in its coverage and easy to read. However, given the lengthy discussion and lack of specific recommendations, it would be difficult for busy clinicians to use it as a quick reference. What I personally appreciate is the fact that it specifically tackles issues that are either controversial or not well understood.