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Doody's Review ServiceReviewer: Aaron Plattner, MD (Pine Rest Christian Mental Health Services)
Description: This book illustrates the different treatment options for patients suffering from treatment resistant depression and the research data behind the specific treatments.
Purpose: Recognizing that treatment resistant depression is a significant issue affecting many patients, the editors strive to provide clinicians with a systematic course of treatment-based research by detailing the treatment roadmap implemented by the University of Michigan Comprehensive Depression Center, followed by the current evidence supporting it.
Audience: The editors identify their primary audience as "clinicians and clinical investigators," but also note that patients, their families and friends, and policy makers also may be able to use this book. However, healthcare providers treating patients with depression will get the most benefit.
Features: The book begins with an overview of the University of Michigan Depression Center roadmap for the approach to patients with treatment resistant depression. Subsequent chapters review treatments for specific populations including adolescents, college students, pregnant women, and the elderly. Other chapters examine the role of comorbid conditions, including substance abuse, medical problems, bipolar disorder, and disturbances in sleep and circadian rhythms. Additional sections review nonpsychopharmacologic treatments, including device-related neuromodulation, peer support, psychotherapeutic options, and the role of exercise and nutrition. The book concludes with an overview of the growing field of genetics. Chapters use tables, graphs, case vignettes, and flowcharts, and end with key clinical concepts and references.
Assessment: Many of the case vignettes represent some of the patients who have been referred to me because they suffer from treatment resistant depression. Several chapters cover patient populations that are often underrepresented in the current literature. While I would recommend reading the first chapter before the other chapters, any chapter can be read in a relatively short time to get clear and concise information on a specific case. The well-written concluding chapter on genetics updates readers on the current research in this exciting area, which has great potential for use in treatment resistant depression. While complementary and alternative treatments are interspersed throughout the book, a specific chapter that reviews all of the potential treatment options that patients are pursuing outside of the traditional medical model, and the research findings behind those treatments, would have been a helpful addition.