Trends and Future Perspectives in Peptide and Protein Drug Delivery / Edition 1

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More About This Textbook


Peptide and protein drug delivery research has been moving at a brisk pace for over 10 years. Trends and Future Perspectives in Peptide and Protein Drug Delivery is a collection of snapshots of the major past and future developments in this exciting field as seen by over 20 invited speakers at a three-day conference on protein drug delivery held on September 2-4, 1993, in Kyoto, Japan. The wide-ranging topics covered included polymeric delivery systems for protein drugs, means of enhancement of protein drug transport, protein modification for improved pharmacokinetic/pharmacodynamic properties, targeting of peptide and protein drugs, and delivery of oligonucleotides and genes.
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Product Details

  • ISBN-13: 9783718656417
  • Publisher: Taylor & Francis
  • Publication date: 2/1/1995
  • Series: Drug Targeting and Delivery Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 392
  • Product dimensions: 6.60 (w) x 9.90 (h) x 1.20 (d)

Table of Contents

Introduction to the Series
List of Contributors
Peptide and Protein Drug Delivery: Past, Present and Future 3
Controlling Protein Diffusion in Hydrogels 23
Poly(ortho esters) for the Pulsed and Continuous Delivery of Peptides and Proteins 39
New Delivery Systems for Recombinant Proteins - Practical Issues from Proof of Concept to Clinic 57
Penetration Enhancement of Peptide Drugs: Palmitoyl Derivatives of Insulin and a Transition-state Mimic Tripeptide Inhibitor of HIV Protease as a Potential Anti-AIDS Drug for Oral Administration 71
Penetration Enhancement of Peptide and Protein Drugs by Electrochemical Means: Transdermal Iontophoresis 83
Technological and Development Issues of Iontophoretic Transport of Peptide and Protein Drugs 111
Enhancement of Transferrin Receptor-mediated Transcytosis for Transepithelial Protein Delivery 135
Peptide Delivery across the Blood-Brain Barrier 153
Improved Circulation Half-life of Proteins Using Deletion Mutants 177
Pathophysiology of Reactive Oxygen Species: Analysis by Targeting SOD 189
Targeting: From Proteins to Genes 199
(Protein)-Targeted Delivery with Particulate Systems 207
Vascular Targeting as a New Approach to the Therapy of Solid Tumors: Validation in a Mouse Tumor Model 241
Recombinant DNA Vaccines: Use of Escherichia coli Envelope Proteins as Tools for Cellular and Molecular Targeting of Foreign Polypeptides in Bacteria and Protein Purification 253
Targeting of Proteins in the Brain following Release from a Polymer 273
Oligonucleotides as Potential Therapeutic Agents 297
Liposomal DNA Delivery 321
Gene Introduction into Animal Tissues 337
Systemic Delivery of Recombinant Proteins by Genetically Engineered Myoblasts 351
Index 365
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