Trissel's Stability of Compounded Formulationsby Lawrence A. Trissel
American Pharmacists Association Errata Trissel's Stability of Compounded Formulations, 5th Edition The lidocaine hydrochloride concentration listed in two places as 40 mg/L is incorrect. It should read 40 mg/mL. The error appears on page 188, third line of Study 1; and on page 289, fourth line under the Topical heading. Correction Sheet Issued October 7, 2013.
American Pharmacists Association Errata Trissel's Stability of Compounded Formulations, 5th Edition The lidocaine hydrochloride concentration listed in two places as 40 mg/L is incorrect. It should read 40 mg/mL. The error appears on page 188, third line of Study 1; and on page 289, fourth line under the Topical heading. Correction Sheet Issued October 7, 2013. This correction sheet may be freely reproduced and distributed. Copyright c 2013 by the American Pharmacists Association. All rights reserved.
Description: The fourth edition of this book arrives only four years after the previous edition, a reflection of the ongoing interest in compounding drug preparations for individual patients, and the data generated to support this pharmaceutical activity.
Purpose: The purpose is to provide those involved in compounding with an adequate reference to meet patient needs and professional obligations. In particular, it is a comprehensive resource for drug stability.
Audience: It is written for pharmacists in community or institutional practices involved in compounding nonparenteral medication. It also can be of use to supporting healthcare providers who have an interest in compounded medications.
Features: This book has grown by over 30 percent since the previous edition to 654 pages - including a 10-page index. The majority is made up of the 433 drug monographs which appear in alphabetical order - from Acetaminophen to Zinc sulfate. Each monograph is similarly structured with sections on drug properties, general stability considerations, stability reports of compounded preparations, compatibility with other drugs, and compatibility with common beverages and foods. The inclusion of this last section and the available physicochemical drug properties in each monograph are appreciated and unique features. The data in each monograph are referenced to the original source. The collection of the 1,233 references is listed in order of citation in its own section of the book. Between the monograph references and the index is a pair of appendixes that provide benchmarks based on USP Guidance for determining beyond-use time points for sterile and nonsterile preparations to be referred to when adequate stability data is unavailable.
Assessment: This is much more than a book of drug formulation recipes. It serves as a valuable source of stability data on compounded nonparenteral drug preparations. The physical quality of the book, especially the binding, may be a concern if this edition is used for more than a few years. Given the continued development of data in this area, each new edition, including this one, is welcome.
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