Trissel's Stability of Compounded Formulations

Overview

Trissel's? Stability of Compounded Formulations is the only book in print that provides a single compilation of all currently available stability information on drugs in compounded oral, enteral, topical, ophthalmic, and other specialized preparations. Using data published during the past 50 years, the reference summarizes specific formulations and stability studies. The book will help readers (a) determine whether formulated compounds will be stable for the anticipated duration of use, (b) properly store and ...
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Overview

Trissel's? Stability of Compounded Formulations is the only book in print that provides a single compilation of all currently available stability information on drugs in compounded oral, enteral, topical, ophthalmic, and other specialized preparations. Using data published during the past 50 years, the reference summarizes specific formulations and stability studies. The book will help readers (a) determine whether formulated compounds will be stable for the anticipated duration of use, (b) properly store and repackage compounded formulations, (c) formulate compounds in accordance with documented standards, and (d) counsel patients on the use and storage of compounded medications. Key Features: • Completely updated monographs on 433 products—an increase of 78 compared with the 3rd edition—are arranged alphabetically by nonproprietary name.
• Each monograph is organized into the following easy-to-use categories: “Properties,” “General Stability Considerations,” and “Stability Reports of Compounded Preparations.”
• Additional categories—”Compatibility with Other Drug Products” and “Compatibility with Common Beverages and Foods”—are included where information is available.
• All 1,233 references—326 new to the 4th edition—are from worldwide literature.
• Appendices summarize United States Pharmacopeia benchmarks for assigning beyond-use periods in the absence of relevant research.
• Index of nonproprietary and brand names is provided.

The book contains no figures.

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Editorial Reviews

Joan M. Stachnik
This book is a summary of the available information on the compounding and stability of extemporaneously prepared dosage forms of commonly used medications. The purpose is to provide practitioners with a reputable and authoritative resource on the stability of compounded formulations. The intended audience is practicing pharmacists involved in extemporaneous compounding of medications. This reference would also be of value to students, technicians, and any clinicians working with special populations (such as pediatrics or geriatrics) where alternative dosage forms may be needed. The reference contains 280 monographs of commonly used medications. Each entry includes information on the physical properties of the medication (such as pH, solubility, osmolality, and/or pka), a review of stability considerations of the medication itself, and a summary of the available published information on the stability of various compounded formulations. Included with the stability information is a description of the methods of preparation of the various formulations when available, and a listing of commercially available dosage forms is at the end of each monograph. Entries are arranged alphabetically making the reference easy to use and each monograph is well referenced. An appendix lists providers of compounding supplies and materials. Although a number of sources can provide information on extemporaneous compounding for specific medications, few if any provide detailed or documented information on the stability of such products. This book gives practitioners a reference that provides both general stability information as well as stability of the product when extemporaneously compounded as acommercially unavailable dosage form. The editor is a well-recognized name in the area of compatibility and stability of dosage forms. This second edition is an update, with an additional 221 published articles included. This reference would be of value to pharmacists practicing in any setting where extemporaneous compounding may be necessary.
Booknews
Compiles all currently available stability information on drugs in compounded oral, enteral, topical, and ophthalmic formulations, drawing on data published over the past 40 years. Helps determine whether formulated compounds will be stable for the duration of use, gives information on storing and repackaging compounded formulations, tells how to formulate in accordance with documented standards, and gives advice on counseling patients on use and storage. Includes a list of chemical suppliers. This edition offer entries on 280 products, and lists 674 references, an increase of 221 over the first edition. Trissel is director of the Clinical Pharmaceutics Research Program at the University of Texas M. D. Anderson Cancer Center. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: Joseph Boullata, PharmD (University of Pennsylvania School of Nursing)
Description: The fourth edition of this book arrives only four years after the previous edition, a reflection of the ongoing interest in compounding drug preparations for individual patients, and the data generated to support this pharmaceutical activity.
Purpose: The purpose is to provide those involved in compounding with an adequate reference to meet patient needs and professional obligations. In particular, it is a comprehensive resource for drug stability.
Audience: It is written for pharmacists in community or institutional practices involved in compounding nonparenteral medication. It also can be of use to supporting healthcare providers who have an interest in compounded medications.
Features: This book has grown by over 30 percent since the previous edition to 654 pages - including a 10-page index. The majority is made up of the 433 drug monographs which appear in alphabetical order - from Acetaminophen to Zinc sulfate. Each monograph is similarly structured with sections on drug properties, general stability considerations, stability reports of compounded preparations, compatibility with other drugs, and compatibility with common beverages and foods. The inclusion of this last section and the available physicochemical drug properties in each monograph are appreciated and unique features. The data in each monograph are referenced to the original source. The collection of the 1,233 references is listed in order of citation in its own section of the book. Between the monograph references and the index is a pair of appendixes that provide benchmarks based on USP Guidance for determining beyond-use time points for sterile and nonsterile preparations to be referred to when adequate stability data is unavailable.
Assessment: This is much more than a book of drug formulation recipes. It serves as a valuable source of stability data on compounded nonparenteral drug preparations. The physical quality of the book, especially the binding, may be a concern if this edition is used for more than a few years. Given the continued development of data in this area, each new edition, including this one, is welcome.

5 Stars! from Doody
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Product Details

  • ISBN-13: 9781582121673
  • Publisher: APhA Publications
  • Publication date: 9/1/2012
  • Series: 5 , #5
  • Edition number: 5
  • Pages: 580
  • Sales rank: 421,533
  • Product dimensions: 8.70 (w) x 11.10 (h) x 1.50 (d)

Table of Contents

PrefaceMonographs Appendix: Suppliers References Index
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