Troubleshooting LC Systems: A Comprehensive Approach to Troubleshooting LC Equipment and Separations / Edition 1

Troubleshooting LC Systems: A Comprehensive Approach to Troubleshooting LC Equipment and Separations / Edition 1

by John W. Dolan, Lloyd R. Snyder
     
 

Over the last 15 years, high-performance liquid chromatogra­ phy (LC) has made the transition from an instrument used only by experts in research labs to a tool used for routine applications by relatively unskilled workers. With this transition have come in instrumentation and column technology. In major advances the past, the operator had to be a… See more details below

Overview

Over the last 15 years, high-performance liquid chromatogra­ phy (LC) has made the transition from an instrument used only by experts in research labs to a tool used for routine applications by relatively unskilled workers. With this transition have come in instrumentation and column technology. In major advances the past, the operator had to be a jack-of-all-trades, with a screw­ driver, soldering iron, and various wrenches as constant compan­ ions in the LC lab. Today, many instruments contain micropro­ cessors as powerful as those of mainframe computers of earlier days. With this technology has come a variety of self-diagnostic tools that allow the LC system to locate many of its own prob­ lems. Traditionally, well-honed LC troubleshooting skills have been a result of years of work at the bench. Today the LC system itself often can do a better job of troubleshooting than the operator can. Yet many of the problems of the past are still the major problems of today: air bubbles, check valves, detector lamps, and, of course, problems with the separation. An added pressure on the operator of today's LC system is that of productivity-the lab often cannot afford unnecessary downtime. This means that the operator has to be a troubleshooting expert, or has to have that expertise at his or her fingertips. The present book was written to provide this expertise in an easy-to-use format for users at all levels of experience.

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Product Details

ISBN-13:
9780896031517
Publisher:
Springer-Verlag New York, LLC
Publication date:
03/28/1989
Edition description:
1989
Pages:
523
Product dimensions:
7.20(w) x 9.48(h) x 1.33(d)

Table of Contents

General Considerations. Logical Approaches to Troubleshooting. Separation Basics. Principles of Troubleshooting. Prevention of Problems. Individual HPLC Modules. Reservoirs and Degassing. Pumps. Tubing. Fittings. Injectors and Autosamplers. Columns. Detectors. Recorders and Data Systems.Troubleshooting the Separation plus Other Problems. Separation Problems: Band Tailing and Peak Distortion. Separation Problems: Other Changes in the Appearance of the Chromatogram. Problems in Quantitation. Other Problems. Index.

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