Tumor Models in Cancer Research

Overview

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of ...

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Overview

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

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Product Details

Meet the Author

Dr. Beverly A. Teicher is Senior Scientific Director in Cancer Research at Genzyme Molecular Oncology and Genzyme Corporation, Framingham, Massachusetts. She has authored or co-authored more than 400 scientific publications, has edited five books, senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.

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Table of Contents

In Memoriam
Preface
Contributors
Pt. I Introduction
1 Perspective on the History of Tumor Models 3
Pt. II Transplantable Syngeneic Rodent Tumors
2 Murine L1210 and P388 Leukemias 23
3 Transplantable Syngeneic Rodent Tumors: Solid Tumors in Mice 41
4 B16 Murine Melanoma: Historical Perspective on the Development of a Solid Tumor Model 73
Pt. III Human Tumor Xenografts
5 Xenotransplantation of Human Cell Cultures in Nude Mice 93
6 GFP-Expressing Metastatic-Cancer Mouse Models 99
7 Human Tumor Xenografts and Explants 113
Pt. IV Carcinogen-Induced Tumors: Models of Carcinogenesis and Use for Therapy
8 Hamster Oral Cancer Model 141
9 Mammary Cancer in Rats 173
10 Carcinogen-Induced Colon-Cancer Models for Chemoprevention and Nutritional Studies 183
Pt. V Mutant, Transgenic, and Knockout Mouse Models
11 Cancer Models: Manipulating the Transforming Growth Factor-[beta] Pathway in Mice 195
12 Cyclin DI Transgenic Mouse Models 223
13 Mice Expressing the Human Carcinoembryonic Antigen: An Experimental Model of Immunotherapy Directed at a Self, Tumor Antigen 231
14 The p53-Deflicient Mouse as a Cancer Model 247
15 The Utility of Transgenic Mouse Models for Cancer Prevention Research 263
Pt. VI Metastasis Models
16 Metastasis Models: Lungs, Spleen/Liver, Bone, and Brain 277
17 Models for Evaluation of Targeted Therapies of Metastatic Disease 293
Pt. VII Normal Tissue Response Models
18 Animal Models of Oral Mucositis Induced by Antineoplastic Drugs and Radiation 323
19 The Intestine as a Model for Studying Stem-Cell Behavior 337
20 SENCAR Mouse-Skin Tumorigenesis Model 359
21 Murine Models of Bone-Marrow Transplant Conditioning 381
22 Anesthetic Considerations for the Study of Murine Tumor Models 407
Pt. VIII Disease and Target-Specific Models
23 Tissue-Isolated Tumors in Mice: Ex Vivo Perfusion of Human Tumor Xenografts 435
24 Human Breast-Cancer Xenografts as Models of the Human Disease 453
25 Animal Models of Melanoma 471
26 Experimental Animal Models for Renal Cell Carcinoma 493
27 Animal Models of Mesothelioma 507
28 SCID Mouse Models of Human Leukemia and Lymphoma as Tools for New Agent Development 521
29 Models for Studying the Action of Topoisomerase-I Targeted Drugs 541
30 Spontaneous Pet Animal Cancers 565
Pt. IX Experimental Methods and End Points
31 In Vivo Tumor Response End Points 593
32 Tumor-Cell Survival 617
33 Apoptosis in Vivo 633
34 Transparent Window Models and Intravital Microscopy: Imaging Gene Expression, Physiological Function, and Drug Delivery in Tumors 647
Index 673
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