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The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.
| In Memoriam | ||
| Preface | ||
| Contributors | ||
| Pt. I | Introduction | |
| 1 | Perspective on the History of Tumor Models | 3 |
| Pt. II | Transplantable Syngeneic Rodent Tumors | |
| 2 | Murine L1210 and P388 Leukemias | 23 |
| 3 | Transplantable Syngeneic Rodent Tumors: Solid Tumors in Mice | 41 |
| 4 | B16 Murine Melanoma: Historical Perspective on the Development of a Solid Tumor Model | 73 |
| Pt. III | Human Tumor Xenografts | |
| 5 | Xenotransplantation of Human Cell Cultures in Nude Mice | 93 |
| 6 | GFP-Expressing Metastatic-Cancer Mouse Models | 99 |
| 7 | Human Tumor Xenografts and Explants | 113 |
| Pt. IV | Carcinogen-Induced Tumors: Models of Carcinogenesis and Use for Therapy | |
| 8 | Hamster Oral Cancer Model | 141 |
| 9 | Mammary Cancer in Rats | 173 |
| 10 | Carcinogen-Induced Colon-Cancer Models for Chemoprevention and Nutritional Studies | 183 |
| Pt. V | Mutant, Transgenic, and Knockout Mouse Models | |
| 11 | Cancer Models: Manipulating the Transforming Growth Factor-[beta] Pathway in Mice | 195 |
| 12 | Cyclin DI Transgenic Mouse Models | 223 |
| 13 | Mice Expressing the Human Carcinoembryonic Antigen: An Experimental Model of Immunotherapy Directed at a Self, Tumor Antigen | 231 |
| 14 | The p53-Deflicient Mouse as a Cancer Model | 247 |
| 15 | The Utility of Transgenic Mouse Models for Cancer Prevention Research | 263 |
| Pt. VI | Metastasis Models | |
| 16 | Metastasis Models: Lungs, Spleen/Liver, Bone, and Brain | 277 |
| 17 | Models for Evaluation of Targeted Therapies of Metastatic Disease | 293 |
| Pt. VII | Normal Tissue Response Models | |
| 18 | Animal Models of Oral Mucositis Induced by Antineoplastic Drugs and Radiation | 323 |
| 19 | The Intestine as a Model for Studying Stem-Cell Behavior | 337 |
| 20 | SENCAR Mouse-Skin Tumorigenesis Model | 359 |
| 21 | Murine Models of Bone-Marrow Transplant Conditioning | 381 |
| 22 | Anesthetic Considerations for the Study of Murine Tumor Models | 407 |
| Pt. VIII | Disease and Target-Specific Models | |
| 23 | Tissue-Isolated Tumors in Mice: Ex Vivo Perfusion of Human Tumor Xenografts | 435 |
| 24 | Human Breast-Cancer Xenografts as Models of the Human Disease | 453 |
| 25 | Animal Models of Melanoma | 471 |
| 26 | Experimental Animal Models for Renal Cell Carcinoma | 493 |
| 27 | Animal Models of Mesothelioma | 507 |
| 28 | SCID Mouse Models of Human Leukemia and Lymphoma as Tools for New Agent Development | 521 |
| 29 | Models for Studying the Action of Topoisomerase-I Targeted Drugs | 541 |
| 30 | Spontaneous Pet Animal Cancers | 565 |
| Pt. IX | Experimental Methods and End Points | |
| 31 | In Vivo Tumor Response End Points | 593 |
| 32 | Tumor-Cell Survival | 617 |
| 33 | Apoptosis in Vivo | 633 |
| 34 | Transparent Window Models and Intravital Microscopy: Imaging Gene Expression, Physiological Function, and Drug Delivery in Tumors | 647 |
| Index | 673 |
Overview
The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of ...