Tumor Models in Cancer Research / Edition 2

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Overview

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

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Product Details

  • ISBN-13: 9781607619673
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/28/2010
  • Series: Cancer Drug Discovery and Development Series
  • Edition description: 2nd ed. 2011
  • Edition number: 2
  • Pages: 694
  • Product dimensions: 6.30 (w) x 9.30 (h) x 1.70 (d)

Meet the Author

Dr. Beverly A. Teicher is Senior Scientific Director in Cancer Research at Genzyme Molecular Oncology and Genzyme Corporation, Framingham, Massachusetts. She has authored or co-authored more than 400 scientific publications, has edited five books, senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.

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Table of Contents

TUMOR MODELS IN CANCER RESEARCH
2nd edition
Beverly A Teicher

Table of Contents

INTRODUCTION

1. Perspectives on the History and Evolution of Tumor Models
Shannon Decker and Edward Sausville

TRANSPLANTABLE SYNGENEIC RODENT TUMORS

2. Murine L1210 and P388 Leukemias
William R Waud

3. Transplantable Syngeneic Rodent Tumors
Lisa Polin, Thomas H. Corbett, Bill J. Roberts, Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White, Juiwanna Kushner, Stuart Hazeldine, Richard Moore, James Rake, and Jerome P. Horwitz

4. B16 Murine Melanomas : Historical Perspective on the Development of a Solid Tumor Model
Enrique Alvarez

HUMAN TUMOR XENOGRAFTS

5. Human Tumor Xenograft Efficacy Models
Ming Liu and Daniel Hicklin

6. Imaging the Steps of Metastasis at the Macro and Cellular Level with Fluorescent Proteins in Real Time
Robert M. Hoffman

7. Patient-derived Tumor Models and Explants
Heinz-Herbert Fiebig and Angelika M. Burger

8. The Pediatric Preclinical Testing Program
Christopher L. Morton and Peter J. Houghton

9. Imaging Efficacy in Tumor Models
Vinod Kaimal, Wilbur R. Leopold, and Patrick McConville

CARCINOGEN-INDUCED TUMORS

10. Mammary Cancer in Rats
Henry J. Thompson

DISEASE AND TARGET-SPECIFIC MODELS

11. Animal Models of Melanoma
Ene T. Fairchild and William E. Carson, III

12. Experimental Animal Models for Investigating Renal Cell Carcinoma Pathogenesis and Preclinical Therapeutic Approaches
Gilda G. Hillman

13. Animal Models of Mesothelioma
Harvey I. Pass, Joseph B. Pincus Michele Carbone, and Magdalena Plasilova

14. The Use of Mouse Models to Study Leukemi /Lymphoma and Assess Therapeutic Approaches
William Siders

15. Spontaneous Companion Animal (Pet) Cancers
David M. Vail and Douglas H. Thamm

GENETICALLY ENGINEERED MOUSE MODELS OF CANCER

16. Genetically Engineered Mouse Models of Pancreatic Ductal Adenocarcinoma
Aram F. Hezel and Nabeel Bardeesy

17. Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP): A Validated Model for the Identification and Characterization of Molecular Targets and the Evaluation of Therapeutic Agents
Sharon D. Morgenbesser

18. Transgenic Mouse Models for Cancer Prevention Research
Stephen D. Hursting, Laura Lashinger, Powel Brown, Susan N. Perkins

METASTASIS MODELS

19. Models for Evaluation of Targeted Therapies of Invasive and Metastatic Disease
Suzanne A. Eccles

NORMAL TISSUE RESPONSE MODELS

20. Animal Models of Toxicities caused by Anti-Neoplastic Therapy
Stephen T. Sonis, Gregory Lyng, and Kimberly Pouliot

21. Bone Marrow as a Critical Normal Tissue
Ralph Parchment

22. Anesthetic Considerations for the Study of Murine Tumor Models
Thies Schroeder, Siqing Shan, Mark W. Dewhirst

EXPERIMENTAL METHODS AND ENDPOINTS

23. Preclinical Tumor Response End Points
Beverly A. Teicher

24. Tumor Cell Survival
Sra Rockwell

25. Apoptosis In Vivo
L.C. Stephens, Luka Milas, K.K. Ang, Katherine A. Mason, and Raymond E. Meyn

26. Transparent Window Models and Intravital Miceoscopy: Imaging Gene Expression, Physiological Function and Therapeutic Effects in Tumors
Rakesh K. Jain, Lance L. Munn, and Dai Fukumura

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