Tumor Suppressor Genes in Human Cancer / Edition 1

by David E. Fisher

Overview

David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

Product Details

ISBN-13:	9781617371981
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/19/2010
Series:	Cancer Drug Discovery and Development
Edition description:	Softcover reprint of hardcover 1st ed. 2001
Pages:	386
Product dimensions:	7.01(w) x 10.00(h) x 0.03(d)

About the Author

Fisher, David E., MD, PhD (Harvard Medical School)

Table of Contents

1 Animal Models for Tumor Suppressor Genes.- 2 Viral Oncoproteins as Probes for Tumor Suppressor Function.- 3 Tumor Suppressors in Metastasis.- 4 Apoptosis: Machinery of Cell Death in Development and Cancer.- 5 Drug Discovery in Oncology.- 6 Retinoblastoma Protein in Growth Control and Differentiation.- 7 p53 Tumor Suppressor Protein.- 8 p16 Tumor Suppressor.- 9 DNA Mismatch Repair in Tumor Suppression.- 10 PTEN: Regulator of Phosphoinositide 3-Kinase Signal Transduction.- 11 Neurofibromatoses.- 12 Von Hippel-Lindau Disease: Clinical and Molecular Aspects.- 13 Wilms’ Tumor: A Developmental Anomaly.- 14 Fanconi Anemia Pathway and Cancer Susceptibility.

Editorial Reviews

3 Stars from Doody

This book, part of the series Cancer Drug Discovery and Development, brings together a panel of experts in the field of cancer biology, with almost half of the authors from Harvard Medical School. The book describes the role of tumor suppressor genes in human cancer. It details a current view of these important genes and highlights clinically relevant aspects of the strides made in the field of tumor suppressor biology. The book is geared towards students of cancer biology, whether they are graduate or medical students, clinicians taking care of cancer patients, and seasoned researchers. It is organized in two parts. Part 1 summarizes the models used in studying the suppressor genes. It also has a detailed chapter on cancer drug discovery. Part 2 provides a detailed description of the individual genes and how they fit into the various pathways. The book is well organized with most chapters having figures and tables to clarify the points made in the text. It is well referenced, though slightly dated with the most recent reference in many of the chapters from 1999. There is some redundancy in the material covered in the book, with overlap in the material between Part 1 and Part 2. This book provides readable, yet thorough, coverage of the field of tumor suppressor biology.

Hidayatullah G. Munshi

Reviews and summarizes the current state of the field. Describes the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, and details major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Discusses animal models, viral oncoproteins as probes, and cancer metastasis, and attempts to link molecular progress in cancer research with improved cancer therapy. Specific topics include p53 tumor suppressor protein, DNA mismatch repair in tumor suppression, neurofibromatoses, and Fanconi anemia pathway and cancer susceptibility. Fisher is affiliated with the Dana Farber Cancer Institute, Harvard Medical School. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Hidayatullah G. Munshi, MD (Northwestern University)
Description: This book, part of the series Cancer Drug Discovery and Development, brings together a panel of experts in the field of cancer biology, with almost half of the authors from Harvard Medical School.
Purpose: The book describes the role of tumor suppressor genes in human cancer. It details a current view of these important genes and highlights clinically relevant aspects of the strides made in the field of tumor suppressor biology.
Audience: The book is geared towards students of cancer biology, whether they are graduate or medical students, clinicians taking care of cancer patients, and seasoned researchers.
Features: It is organized in two parts. Part 1 summarizes the models used in studying the suppressor genes. It also has a detailed chapter on cancer drug discovery. Part 2 provides a detailed description of the individual genes and how they fit into the various pathways. The book is well organized with most chapters having figures and tables to clarify the points made in the text. It is well referenced, though slightly dated with the most recent reference in many of the chapters from 1999. There is some redundancy in the material covered in the book, with overlap in the material between Part 1 and Part 2.
Assessment: This book provides readable, yet thorough, coverage of the field of tumor suppressor biology.

Doody's Review Service

"...brings together a panel of experts in the field of cancer biology, with almost half of the authors from Harvard Medical School. ...describes he role of tumor suppressor genes in human cancer. It details a current view of these important genes and highlights clinically relevant aspects of the strides made in the field of tumor suppressor biology. ...The book is well organized with most chapters having figures and tables to clarify the points made in the text. It is well referenced....This book provides readable, yet thorough, coverage of the field of tumor suppressor biology." -Doody's Health Sciences Book Review Journal

From the Publisher