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Doody's Review ServiceReviewer: Hidayatullah G. Munshi, MD (Northwestern University)
Description: This book, part of the series Cancer Drug Discovery and Development, brings together a panel of experts in the field of cancer biology, with almost half of the authors from Harvard Medical School.
Purpose: The book describes the role of tumor suppressor genes in human cancer. It details a current view of these important genes and highlights clinically relevant aspects of the strides made in the field of tumor suppressor biology.
Audience: The book is geared towards students of cancer biology, whether they are graduate or medical students, clinicians taking care of cancer patients, and seasoned researchers.
Features: It is organized in two parts. Part 1 summarizes the models used in studying the suppressor genes. It also has a detailed chapter on cancer drug discovery. Part 2 provides a detailed description of the individual genes and how they fit into the various pathways. The book is well organized with most chapters having figures and tables to clarify the points made in the text. It is well referenced, though slightly dated with the most recent reference in many of the chapters from 1999. There is some redundancy in the material covered in the book, with overlap in the material between Part 1 and Part 2.
Assessment: This book provides readable, yet thorough, coverage of the field of tumor suppressor biology.