Tumour Angiogenesis / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$220.00
Used and New from Other Sellers
Used and New from Other Sellers
from $26.29
Usually ships in 1-2 business days
(Save 88%)
Other sellers (Hardcover)
  • All (8) from $26.29   
  • New (4) from $231.32   
  • Used (4) from $26.29   

Overview

This is the first comprehensive book to cover all areas of a rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases, extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis, including vascular endothelial growth factor, the basic fibroblast growth factor family, transforming growth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumor microvessel density and the therapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.

The book contains predominantly black-and-white illustrations, with some color illustrations.

Read More Show Less

Product Details

  • ISBN-13: 9780198549376
  • Publisher: Oxford University Press, USA
  • Publication date: 1/28/1997
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 408
  • Product dimensions: 7.80 (w) x 9.60 (h) x 1.10 (d)

Table of Contents

1. Introduction, Bicknell, Lewis & Ferrara
2. In Vivo Models of Angiogenesis, Fan & Polverini
3. Mechanistic Studies of Tumour Angiogenesis, Bicknell
4. Prognostic and Predictive Value of Intra-tumoral Microvessel Density in Human Solid Tumours, Gasparini
5. Vascular and Interstitial Physiology of Tumours: Role in Cancer Detection & Treatment, Jain
6. Microregional Tumour Blood Flow: Heterogeneity & Therapeutic Significance, Chaplin, Trotter, & Dougherty
7. Mechanisms of Stress-Induced Angiogenesis in Tumours, Keshet, Stein, Neeman
8. The role of Macrophages in Tumour Angiogenesis, Leek, Lewis, & Harris
9. Oncogenes and Tumour Suppressor Genes in the Regulation of Angiogenesis, Rastinejad & Bouck
10. The role of cytokines in angiogenesis, Lewis & Balkwill
11. The Role of Proteases in Angiogenesis, Bikfalvi, Klein, & Pintucci
12. Involvement of the Extracellular Matrix, Heparan Sulfate Proteoglycans and Heparan Sulfate Degrading Enzymes in Angiogenesis and Metastasis, Vlodavsky, Miao, Ishai-Michaeli, Benezra, Levy, Bar-Shavit & Peretz
13. The Role of Collagens and Proteoglycans in Tumour Angiogenesis, Rooney, Kumar, Ponting & Kumar
14. The Physiological Importance and Therapeutic Potential of Nitric Oxide in the Tumour-associated Vasculature, Hisrt & Flitney
15. Vascular Derived Growth Factors: Potential Role in the Development of the Tumour Vasculature, Bobik, Agrotis & Little
16. The Role of Vascular Endothelial Growth Factor in the Regulation of Blood Vessel Growth, Ferrara
17. The Role of Fibroblast Growth Factors in Tumour Progression and Angiogenesis, Christofori
18. The Biphasic Effects of Transforming Growth Factor in Angiogenesis, Madri & Sankar
19. Thymidine phosphorylase/platelet-derived endothelial cell growth factor an angiogenc enzyme, Moghaddam, Choudhuri & Bicknell
20. Tumor Necrosis Factor and Angiogenesis, Fajardo & Allison
21. Pleiotrophin and Related Molecules, Schulte & Wellstein
22. The Involvement of prostanoids in angiogenesis, Spisni & Tomasi
23. The Inhibition of tumour angiogenesis, Bicknell & Holmgren
24. Endothelial Cells Transformed by Polyomavirus Middle-T Oncogene: A Model for Haemangiomas and Other Vascular Tumours, Pepper, Tacchini-Cottier, Sabapathy, Montesano & Wagner
25. Development of the Embryonic Vascular System, Young & Laskey
26. Targeting the Tumour Endothelium Using Specific Antibodies, Derbyshire & Thorpe
27. Vascular Targeting of anti-cancer gene therapy, Bicknell

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)