Tumour Angiogenesis / Edition 1

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This is the first comprehensive book to cover all areas of a rapidly expanding research area. Each chapter is written by world experts in the field and topics covered include in vivo models, mechanisms, inhibition, and the role of macrophages, cytokines, proteases, extracellular matrix components, nitric oxide, prostanoids and oncogenes/tumour suppressor genes in angiogenesis. Other chapters examine the role of specific growth factors in angiogenesis, including vascular endothelial growth factor, the basic fibroblast growth factor family, transforming growth factor-beta, tumour necrosis factor-alpha, platelet-derived endothelial cell growth factor/thymidine phosphorylase and pleiotrophin and related molecules. Clinical issues are addressed in chapters that deal with the prognostic and predictive value of tumor microvessel density and the therapeutic significance of microregional blood flow. The two final chapters examine the feasibility of targeting tumour vasculature using either antibodies or gene therapy.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Product Details

  • ISBN-13: 9780198549376
  • Publisher: Oxford University Press, USA
  • Publication date: 1/28/1997
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 408
  • Product dimensions: 7.80 (w) x 9.60 (h) x 1.10 (d)

Table of Contents

1. Introduction, Bicknell, Lewis & Ferrara
2. In Vivo Models of Angiogenesis, Fan & Polverini
3. Mechanistic Studies of Tumour Angiogenesis, Bicknell
4. Prognostic and Predictive Value of Intra-tumoral Microvessel Density in Human Solid Tumours, Gasparini
5. Vascular and Interstitial Physiology of Tumours: Role in Cancer Detection & Treatment, Jain
6. Microregional Tumour Blood Flow: Heterogeneity & Therapeutic Significance, Chaplin, Trotter, & Dougherty
7. Mechanisms of Stress-Induced Angiogenesis in Tumours, Keshet, Stein, Neeman
8. The role of Macrophages in Tumour Angiogenesis, Leek, Lewis, & Harris
9. Oncogenes and Tumour Suppressor Genes in the Regulation of Angiogenesis, Rastinejad & Bouck
10. The role of cytokines in angiogenesis, Lewis & Balkwill
11. The Role of Proteases in Angiogenesis, Bikfalvi, Klein, & Pintucci
12. Involvement of the Extracellular Matrix, Heparan Sulfate Proteoglycans and Heparan Sulfate Degrading Enzymes in Angiogenesis and Metastasis, Vlodavsky, Miao, Ishai-Michaeli, Benezra, Levy, Bar-Shavit & Peretz
13. The Role of Collagens and Proteoglycans in Tumour Angiogenesis, Rooney, Kumar, Ponting & Kumar
14. The Physiological Importance and Therapeutic Potential of Nitric Oxide in the Tumour-associated Vasculature, Hisrt & Flitney
15. Vascular Derived Growth Factors: Potential Role in the Development of the Tumour Vasculature, Bobik, Agrotis & Little
16. The Role of Vascular Endothelial Growth Factor in the Regulation of Blood Vessel Growth, Ferrara
17. The Role of Fibroblast Growth Factors in Tumour Progression and Angiogenesis, Christofori
18. The Biphasic Effects of Transforming Growth Factor in Angiogenesis, Madri & Sankar
19. Thymidine phosphorylase/platelet-derived endothelial cell growth factor an angiogenc enzyme, Moghaddam, Choudhuri & Bicknell
20. Tumor Necrosis Factor and Angiogenesis, Fajardo & Allison
21. Pleiotrophin and Related Molecules, Schulte & Wellstein
22. The Involvement of prostanoids in angiogenesis, Spisni & Tomasi
23. The Inhibition of tumour angiogenesis, Bicknell & Holmgren
24. Endothelial Cells Transformed by Polyomavirus Middle-T Oncogene: A Model for Haemangiomas and Other Vascular Tumours, Pepper, Tacchini-Cottier, Sabapathy, Montesano & Wagner
25. Development of the Embryonic Vascular System, Young & Laskey
26. Targeting the Tumour Endothelium Using Specific Antibodies, Derbyshire & Thorpe
27. Vascular Targeting of anti-cancer gene therapy, Bicknell

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