Tuning the Brain


Discover effective, outcome-oriented ways to help CFS patients who have endured useless or inappropriate treatments! From the author: "For many years I have viewed brain function as a system of electrochemical impulses continually flashing through the brain. These neural networks can often be modulated fairly simply by 'tuning' them. The point I have been trying to make for many years is that this process may be pharmacologically regulated extremely rapidly in a manner which does not yet seem to be recognized by ...

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Discover effective, outcome-oriented ways to help CFS patients who have endured useless or inappropriate treatments! From the author: "For many years I have viewed brain function as a system of electrochemical impulses continually flashing through the brain. These neural networks can often be modulated fairly simply by 'tuning' them. The point I have been trying to make for many years is that this process may be pharmacologically regulated extremely rapidly in a manner which does not yet seem to be recognized by the medical profession." In this remarkable volume, Dr. Jay A. Goldstein clearly presents both the theoretical and the practical aspects of his revolutionary approach to treating CFS and other conditions that have often been termed psychosomatic. Dr. Goldstein (author of Chronic Fatigue Syndromes: The Limbic Hypothesis and Betrayal by the Brain: The Neurologic Basis of Chronic Fatigue Syndrome, Fibromyalgia Syndrome, and Related Neural Network Disorders) shows how he achieves results for patients with CFS and a variety of other syndromes in days, rather than months or years. This well-referenced book answers questions, from the most basic to the most complex, including: What is neurosomatic medicine? How did Dr. Goldstein come to pioneer and practice this specialty? What abnormalities in brain function produce neurosomatic disorders? How can an understanding of these abnormalities help you provide effective treatment? Why do these treatments sometimes work so rapidly? What is receptor profiling, and how does it indicate the type of receptor dysregulation in an individual patient? In Part I: Inventing Neurosomatic Medicine, Dr. Goldstein describes the remarkable how and why of his life and his development of this new field of medicine, including his clashes with the medical/psychoanalytic establishment. One of the greatest medical innovators of the modern era, Dr. Goldstein has seen over 20,000 CFS patients and has exp

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Editorial Reviews

Doody's Review Service
Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: Fibromyalgia and chronic fatigue syndrome are two frequent problems encountered in the general population. They are, however, misunderstood and underscored by many. Therefore, an updated review on the topic is useful for non-believers and experts in the subject alike.
Purpose: The purpose of this book is to address fibromyalgia and chronic fatigue syndrome in a diverse approach. In my perspective, those were worthy objectives fully achieved by the authors.
Audience: The audience comprises mostly family practitioners, neurologists, neurosurgeons, and internists. In my view, the target population was completely reached by the author, who is an expert on the topic.
Features: The book is written in a very unique style, almost like a novel. However, the context is scientific enough to expose the bases for fibromyalgia and chronic fatigue syndrome. I think that any other exposure would lead into failure; as many professionals do not totally agree even with the true existence of those syndromes. Treatment is controversial and outcome, variable. However, the book is well written, has good quality pictures, and deviates from a formal style. The price is equipotent to the interest I would find in buying this book.
Assessment: I think it is overkill to add this book to any library. The contents are fine, but not attractive enough to a general or neurosciences library.
Gail R. Kansky
A LUCID, WONDERFUL, AND WONDER-FILLED BOOK crammed with patient-tested secrets based on years of clinical experience. If more physicians had Dr. Goldstein's ability to see and respond to the needs of their patients, the world would not be filled with the distrust for medical practitioners that is so prevalent today. The author was and is years ahead of his time in understanding how the brain functions and has taken neurosomatic medicine to new heights. Both the book and the man can be described in one word: BRILLIANT.
BSEd, President, National CFIDS Foundation, Inc.
Robert Bennett
In the context of this book, neurosomatic is defined as 'an inappropriate handling of sensory and cognitive input by the brain.' Indeed, there is now abundant evidence that abnormal processing of sensory and cognitive input is at the root of the symptoms experienced by patients with disorders such as chronic fatigue, irritable bowel, and fibromyalgia. This book is a useful compendium of contemporary neuroscience and I RECOMMEND IT TO HEALTH CARE PROFESSIONALS who are interested in designing an innovative approach to the management of these difficult disorders. . . . Provides the background material for creative poly-pharmacy . . .
MD, FRCP, Professor of Medicine, Oregon Health & Science University; Editor, The Clinical Neurobiology of Fibromyalgia and Myofascial Pain: Therapeutic Implications

3 Stars from Doody
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Product Details

  • ISBN-13: 9780789022462
  • Publisher: Taylor & Francis
  • Publication date: 11/28/2003
  • Pages: 670
  • Product dimensions: 6.00 (w) x 8.30 (h) x 1.60 (d)

Table of Contents

  • Foreword
  • Preface
  • Abbreviations
  • Part I: Inventing Neurosomatic Medicine: Rewards and Satisfactions versus Problems and Pitfalls
  • Chapter 1. The Education of a Neurosomaticist
  • Chapter 2. The Office Practice of Neurosomatic Medicine
  • Bankruptcy Despite a Three-Month Waiting List
  • Solving the Problems and Avoiding the Pitfalls
  • Taking Care of Business
  • Chapter 3. Lawyers and Litigation
  • Sample Pathophysiology of Posttraumatic Fibromyalgia
  • Mene, Mene, Tekel, Upharsin
  • Chapter 4. Treatment Case Examples
  • Instantaneous Neural Network Reconfiguration by Pharmacologic Modulation of Afferent Cranial Nerve Input
  • The Pathophysiology of CFS and Related Neurosomatic Disorders
  • Thyroid Function in Neurosomatic Disorders: Stimulation of Trigeminal Nerve Activity with Thyrotropin-Releasing Hormone (TRH)
  • Chapter 5. Case Reports
  • My So-Called Illness: Is It Real or All in My Head?
  • One-Second Epiphanies
  • My Most Unusual Case
  • Bug-of-the-Month Club
  • Chapter 6. Married to a Doctor Who Is Married to His Practice
  • Part II: Society for Neuroscience Conference Proceedings
  • Chapter 7. This Is . . . Los Angeles
  • Chapter 8. Neurosomatic Pearls
  • Eldritch Lore About Neurosomatic Therapy
  • Chapter 9. Neurosomatic Neuroscience
  • Part III: Pathophysiology and Treatment
  • Chapter 10. Treatment of Neurosomatic Disorders
  • Abecarnil and Acamprosate
  • Stimulants
  • The Corticostriatal-Thalamocortical (CSTC) Circuit in Reverse
  • Corticotropin-Releasing Hormone (CRH) and Hypocortisolism
  • Agmatine
  • Cholinesterase Inhibitors
  • Ascorbate (Vitamin C)
  • Amantadine
  • Adenosine
  • Baclofen
  • Gamma-Aminobutyric Acid (GABA)
  • Adenosine Triphosphate (ATP)
  • Lorazepam Nasal Spray
  • Antibiotics
  • Endothelin (ET)
  • Respiratory Rhythm Regulation in Fibromyalgia Syndrome
  • pH and Panic Disorder
  • Buspirone/BuSpar
  • Thalamic Reticular Nucleus
  • The Attentional Network
  • Clonidine
  • Catecholamines
  • Norepinephrine, Dopamine, Salience, and Attention
  • Dopamine and Reward
  • Effexor (Venlafaxine)
  • Synaptic Plasticity and Long-Term Potentiation in Neurosomatic Disorders
  • The Postreceptor Phosphorylation Cascade
  • The Treatment of Attentional Disorders
  • Instantaneous Neural Network Reconfiguration
  • Other Aspects of Synaptic Plasticity
  • Hormonal Modulation in Neurosomatic Medicine
  • Modulating the N-Methyl-D-Aspartate (NMDA) Receptor
  • Atypical Messengers
  • Synaptic Fatigue
  • Glutamate Receptors, Subunits, and Synaptic Scaling
  • Neurotrophic Factors
  • Metabotropic Glutamate Receptors
  • Conclusion
  • Chapter 11. Modulating Glutamatergic Neurotransmission
  • Ketamine
  • Pharmacologic Modulation of Sensory Integration via the Trigeminal Nerve
  • Electroconvulsive Therapy (ECT)
  • Kinases and Phosphatases
  • The Nicotinic Cholinergic Receptor
  • Long-Term Potentiation and Depression
  • Mitogen-Activated Protein Kinases (MAPKs)
  • Gabapentin
  • Zolpidem
  • Lamotrigine
  • Pentazocine (Talwin)
  • Oxytocin
  • Opioids
  • Oxytocin, Hypothalamic Function, and Circadian Rhythms
  • Other Effects of Oxytocin
  • Modafinil (Provigil)
  • Ventrolateral Preoptic Nucleus (VLPO)
  • Lidocaine
  • Gonadotropin-Releasing Hormone (GnRH) and Dysregulation of Circadian Rhythms
  • Pyrrolidines
  • Fatigue
  • Sleep
  • Conclusion
  • Conclusion. Closing the Circuit: The Role of the Nucleus Accumbens in Neurosomatic Disorders
  • Appendix
  • Diagnostic Criteria from the DSM-IV-TR
  • Treatment Algorithm
  • Medication List: Present and Near-Future Treatment Options for Neurosomatic Disorders
  • CFS Symptom Checklist
  • References
  • Index
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