Type 1 Diabetes

Overview

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing ? cells in the pancreas by the body's immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a detailed examination of our ...

See more details below
Other sellers (Hardcover)
  • All (7) from $86.04   
  • New (5) from $90.45   
  • Used (2) from $86.04   
Sending request ...

Overview

Type 1 diabetes, also known as juvenile-onset or insulin-dependent diabetes mellitus (IDDM), is caused by destruction of insulin-producing ? cells in the pancreas by the body's immune system. It affects hundreds of thousands of individuals worldwide, requiring regular insulin injections to control blood glucose levels and avoid severe consequences of glucose dysregulation. Written by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a detailed examination of our understanding of the disease process and its causes, as well as genetic risk factors, animal models of diabetes, and new treatment strategies that are being developed.

Read More Show Less

Product Details

  • ISBN-13: 9781936113217
  • Publisher: Cold Spring Harbor Laboratory Press
  • Publication date: 6/12/2012
  • Pages: 305
  • Product dimensions: 7.30 (w) x 10.30 (h) x 0.80 (d)

Table of Contents

Preface vii

The Pathogenesis and Natural History of Type 1 Diabetes Mark A. Atkinson 1

Breakdown in Peripheral Tolerance in Type 1 Diabetes in Mice and Humans Lukas T. Jeker Hélène Bour-Jordan Jeffrey A. Bluestone 19

Generating β Cells from Stem Cells-The Story So Far Matthias Hebrok 39

Endoplasmic Reticulum Stress, Pancreatic β-Cell Degeneration, and Diabetes Feroz R. Papa 51

Genetics of Type 1 Diabetes Janelle A. Noble Henry A. Erlich 69

Humoral Autoimmunity in Type 1 Diabetes: Prediction, Significance, and Detection of Distinct Disease Subtypes Massimo Pietropaolo Roberto Towns George S. Eisenbarth 85

Immunologic and Metabolic Biomarkers of (β-Cell Destruction in the Diagnosis of Type 1 Diabetes Jasmin Lebastchi Kevan C. Herald 103

Islet Autoantigens: Structure, Function, Localization, and Regulation Peter Arvan Massimo Pietropaolo David Ostrov Christopher J. Rhodes 117

Do MHCII-Presented Neoantigens Drive Type 1 Diabetes and Other Autoimmune Diseases? Philippa Marrack John W. Kappler 137

Antigen Targets of Type 1 Diabetes Autoimmunity Bart O. Roep Mark Peakman 155

The Hygiene Hypothesis: An Explanation for the Increased Frequency of Insulin-Dependent Diabetes Jean-François Bach Lucienne Chatenoud 169

Environmental Triggers of Type 1 Diabetes Mikael Knip Olli Simell 179

Virus Infections in Type 1 Diabetes Ken T. Coppieters Tobias Boettler Matthias von Herrath 195

Connecting Type 1 and Type 2 Diabetes through Innate Immunity Justin I. Odegaard Ajay Chawla 209

Advancing Animal Models of Human Type 1 Diabetes by Engraftment of Functional Human Tissues in Immunodeficient Mice Michael A. Brehm Alvin C. Powers Leonard D. Shultz Dale L. Greiner 227

Antigen-Specific Therapeutic Approaches in Type 1 Diabetes Xavier Clemente-Casares Sue Tsai Carol Huang Pere Santamaria 241

Clinical Immunologic Interventions for the Treatment of Type 1 Diabetes Lucienne Chatenoud Katharina Warncke Anette-G. Ziegler 265

Update on Islet Transplantation Michael McCall A.M. James Shapiro 283

Index 299

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)