Ultradian Rhythms from Molecules to Mind: A New Vision of Life / Edition 1

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More About This Textbook


Ultradian rhythms play an essential part at all levels of biological organization, providing timekeeping for intracellular processes, playing various roles in intracellular signalling systems and underpinning coherent behaviour in tissues and organs. They are crucial to endocrine and neural performance and in psychobiology. This book brings together the evidence for these findings. In lower eukaryotes short-period rhythms (period 30-70 min) are coupled to an ultradian clock which serves as a central timekeeper. In metazoans, similar rhythms are necessary for intercell communications, and temporal coupling for the coordination of integrated functions of tissues and organs to provide "homeodynamics" of the whole organism. Electrical, endocrine and behavioural rhythms characterize both wakefulness and sleep; pathologically disordered states give rise to dynamic diseases. Chapters on human movements, sleep, attention span and alertness indicate the broad span of this subject. A continuum can now be traced from the molecular genetic, through the cellular and neuroendocrine to the behavioural and psychosocial levels. Many of the results presented in this book are recent and novel, and have far-reaching consequences for our understanding of health and disease. Our first book (published 15 years ago) ended with " Epilogue :The Unification Hypothesis of Chronobiology-Psychobiology from Molecule to Mind". In retrospect we can now recognise how this epilogue was a prescient vision of what is now the cutting edge of epigenetics, bioinformatics, systems biology, neuroscience, and the new sciences of consciousness that are the foundation for the emerging vision of life and philosophy in our current era. Each of the four parts of this book are successive iterations towards this new integration of the life sciences from molecule to mind and spirit in the emergent ethos of the future.

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Product Details

  • ISBN-13: 9781402083518
  • Publisher: Springer Netherlands
  • Publication date: 11/28/2008
  • Edition description: 2008
  • Edition number: 1
  • Pages: 450
  • Product dimensions: 6.30 (w) x 9.30 (h) x 0.90 (d)

Table of Contents

Acknowledgements vii

Introduction: The Temporal Organization of Living Systems from Molecule to Mind D. Lloyd E.L. Rossi M.R. Roussel 1

Part I The Molecular-Genetic-Cellular Level

1 The Ultradian Clock ([tilde]40 min) in Yeast Saccharomyces cerevisiae D. Lloyd D.B. Murray R.R. Klevecz J. Wolf H. Kuriyama 11

2 ENOX Proteins: Copper Hexahydrate-Based Ultradian Oscillators of the Cell's Biological Clock D.J. Morre D.M. Morre 43

3 Self-Organized Intracellular Ultradian Rhythms Provide Direct Cell-Cell Communication V.Y. Brodsky D. Lloyd 85

4 Phosphorylation Dynamics in Mammalian Cells D.A. Gilbert K.D. Hammond 105

5 Is There a Mitochondrial Clock? M.A. Aon S. Cortassa B. O'Rourke 129

Part II Invertebrate Systems

6 Ultradian and Circadian Rhythms: Experiments and Models B. Fuentes-Pardo C. Barriga-Montoya M. Lara-Aparicio S. Lopez de Medrano 147

7 Ultradian Lovesong Rhythms in Drosophila C.P. Kyriacou 163

8 Mid-range Ultradian Rhythms in Drosophila and the Circadian Clock Problem H.B. Dowse 175

9 Tidal Rhythms M.K. Chandrashekaran V.K. Sharma 201

Part III The Neuroendocrineal and Developmental Level

10 Pulsatile Hormone Secretion: Mechanisms, Significance and Evaluation J.D. Veldhuis 229

11 Ultradian Rhythms as the Dynamic Signature of Life F.E. Yates L.B. Yates 249

12 The Mammalian Circadian Timekeeping System U. Schibler 261

Part IV Ultradian and Circadian Rhythms in Human Experience

13 Ultradian Cognitive Performance Rhythms During Sleep Deprivation C.M. LaJambe F.M. Brown 283

14 High Frequency EEG and Its Relationship to Cognitive Function H.C. Sing 303

15 Total Sleep Deprivation and Cognitive Performance: The Case for MultipleSources of Variance H. Babkoff A. Goldstein G. Zukerman 343

16 Open Questions on Mind, Genes, Consciousness, and Behavior: The Circadian and Ultradian Rhythms of Art, Beauty, and Truth in Creativity E.L. Rossi K.L. Rossi 391

17 Genes, Sleep and Dreams S. Ribeiro S. Simoes M. Nicolelis 413

18 Epilogue: A New Vision of Life D. Lloyd E.L. Rossi 431

Index 441

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