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The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging

Paperback (Softcover reprint of the original 1st ed. 1993)
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Editorial Reviews

Developed from the proceedings of the workshop (on title), held in Annapolis, Maryland, June 1990, to bring together scientists from diverse disciplines in cancer biology, epidemiology, molecular biology, genetics, immunology, gerontology, and drug resistance to discuss the possible underlying factors that may account for the increase in cancer incidence and mortality among the elderly. The 23 papers are organized in sections devoted to background, genetics and epigenetics, influence of physiological changes in the immune constitutions in aging and cancer, molecular biology of age-related changes in some types of cancer (breast cancer, prostate cancer), molecular epidemiology and treatment modality in patients of different ages with leukemias, drug resistance, and summation and synthesis. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9781461362708
  • Publisher: Springer US
  • Publication date: 4/30/2013
  • Series: Advances in Experimental Medicine and Biology Series , #330
  • Edition description: Softcover reprint of the original 1st ed. 1993
  • Edition number: 1
  • Pages: 336
  • Product dimensions: 7.01 (w) x 10.00 (h) x 0.74 (d)

Table of Contents

Background.- Aging, Comorbidity, and Breast Cancer Survival: An Epidemiologic View.- Squamous Cell Cancer of the Cervix, Immune Senescence and HPV: Is Cervical Cancer an Age-Related Neoplasm?.- Genetics and Epigenetics.- Genetic and Molecular Basis for Cellular Senescence.- A Single Gene Change Can Extend Yeast Life Span: The Role of ras in Cellular Senescence.- A Comparison of the Properties of Human P53 Mutant Alleles.- Gene Structure and Expression in Colorectal Cancer.- Influence of Physiological Changes in the Immune Constitutions in Aging and Cancer.- Tumors and Aging: The Influence of Age-Associated Immune Changes upon Tumor Growth and Spread.- T Cell Differentiation and Functional Maturation in Aging Mice.- Molecular Biology of Age-Related Changes in Some Types of Cancer.- I. Breast Cancer.- Cytogenetics and Clinical Correlations in Breast Cancer.- Breast Cancer: Influence of Endocrine Hormones, Growth Factors and Genetic Alterations.- Regulation of Estrogen Receptor Expression in Breast Cancer.- Aging and Development of Ovarian Epithelial Carcinoma: The Relevance of Changes in Ovarian Stromal Androgen Production.- II. Prostate Cancer.- Prostatic Cancer: An Age-Old Problem.- Stromal-Epithelial Paracrine Interactions in the Neoplastic Rat and Human Prostate.- Heparin-Binding Fibroblast Growth Factors and Prostate Cancer.- Molecular Epidemiology and Treatment Modality in Patients of Different Ages with Leukemias.- Age Related Changes in Adults with Acute Leukemia.- Significance of Chromosomal Chances in Patients of Different Age Groups with Acute Leukemia.- Glucocorticoid Receptors in Leukemias, Lymphomas and Myelomas of Young And Old.- Drug Resistance.- General Aspects of Cancer Chemotherapy in the Aged.- Drug Resistance and Cancer.- Summation and Synthesis.- From the Cancer Cell Biology Point of View.- From the Immunology Point of View.- From the Aging Point of View.- Participants and Contributors.
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