Understanding and Modulating Aging / Edition 1

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For the last 40 years, biogerontology-the study of the biological basis of aging-has progressed tremendously, and it has now become an independent and respected field of study and research. This volume brings together contributions by biogerontologists, bioethicists, biodemographers, researchers, students, clinicians, and dieticians.The main areas of discussion and presentation of new research results include (1) biological and non-biological factors affecting lifespan and the quality of life; (2) ethical and social issues related to lifespan and health-span extension; (3) physiological, cellular, and molecular aspects of aging; (4) new technologies to understand and modulate aging; (5) the latest successful approaches in the prevention and treatment of age-related diseases, and (6) aging intervention, prevention, and modulation by genes, natural and synthetic molecules, and lifestyle modifications.Accordingly, the main sections of the volume focus on the following topics: defining aging, longevity, and the diseases of aging; selected aging organs; cellular aging; molecular aging; ethics of aging intervention; genetics of aging and longevity; and aging interventions.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit

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Table of Contents

Introduction: Suresh I.S. Rattan, Peter Kristensen, Brian F.C.Clark.

1. Aging is No Longer an Unsolved Problem in Biology. RobinHolliday.

2. Free Radical theory of Aging: an Update, and increasing theFunctional Life Span. Denham Harman.

3. The Free Radical Phantasm: A Panoply of Paradoxes. RandolphM. Howes.

4. Catabolic insufficiency and Aging. Alexei Terman.

5. Methionine Sulfoxide Reductases: Relevance to Aging andProtection Against Oxidative Stress. Filipe Cabreiro, CédricR. Picot, Bertrand Friguet, Isabelle Petropoulos.

6. Inadequate Intensity of Various Components of TotalEnvironmental Signals Can Lead to Natural Aging. Alexander V.Khalyavkin, anatoli I Yashin.

7. Cellular Redox Regulation and Pro-Oxidant Signalling Systems:A New Perspective on the Free Radical theory of Aging. anthony W.Linnane, Hayden Eastwood.

8. Human Immunosenescence: Does it Have an infectiousComponent?. G. Pawelec, S. Koch, C. Franceschi, A. Wikby.

9. Aging in Mouse and Human Systems: a Comparative Study. LloydDemetrius.

10. Extrapolaholics anonymous: Why Demographers’Rejections of A Huge Rise in Cohort Life Expectancy This CenturyAre Overconfident. Aubrey D.N.J. De Grey.

11. The Value of Life and the Value of Life Extension. StevenHorrobin.

12. Oxphos Supercomplexes: Respiration and Lifespan Control inthe Aging Model. Podospora anserina Frank Krause, Christian Q.Scheckhuber, Alexandra Werner, Sascha Rexroth, Nicole H.Reifschneider, Norbert A. Dencher, Heinz D. Osiewacz.

13. Unraveling Age-Dependent Variation of the MitochondrialProteome. Norbert A. Dencher, Sataro Goto, Nicole H. Reifschneider,Michiru Sugawa, Frank Krause.

14. Stress and Ageing in Caenorhabditis Elegans. anders Olsen,Maithili C. Vantipalli, Gordon J. Lithgow.

15. Age-Dependent Decrease in Renal Glucocorticoid ReceptorFunction is Reversed by Dietary Restriction in Mice. Ramesh Sharma,Debipreeta Dutta.

16. Investigation of Differentially Expressed Genes in theVentricular Myocardium of Senescent Rats. Akira Ishihata, YumiKatano.

17. Naive T Cells in the Elderly – Are they Still there?.Gerald Pfister, Daniela Weiskopf, Lutfan Lazuardi, Rania D.Kovaiou, Beatrix Grubeck-Loebenstein.

18. Brain Lipopigment Accumulation in Normal and PathologicalAging. Dan Riga, Sorin Riga, Florin Halalau, FranciscSchneider.

19. Aging and Orchidectomy Modulate Expression of Vegf Receptors(Flt-1 and Flk-1) on Corpus Cavernosum of the Rat. Delminda Neves,Janete Santos, Nuno Tomada, Henrique Almeida.

20. Role of angiotensin Ii and Endothelin-1 Receptors in theAging-Related Functional Changes in Rat Cardiovascular System.Akira Ishihata, Yumi Katano.

21. Mitochondria Damage Checkpoint, Aging and Cancer. Keshav K.Singh.

22. Free Radical Production by Aminoguanidine Damages DNA.George Suji, S Sivakami.

23. Effect of Lipid Restriction on Mitochondrial Free RadicalProduction and Oxidative DNA Damage. Alberto Sanz, Pilar Caro, JoseGomez Sanchez, Gustavo Barja.

24. Increased Production of H2O2 As Premature SenescenceEstablishes in Human Fibroblasts After a Short Sublethal Exposureto H2O2. Stephanie Zdanov, Jose Remacle, Olivier Toussaint.

25. Carf Regulates P19arf-P53-P21waf1 Senescence Pathway byMultiple Check-Points. Sunil C. Kaul, Kamrul Hasan, RenuWadhwa.

26. Structural and Functional Differences Between Mouse Mot-1and Mot-2 Proteins That Differ in Two Amino Acids. Custer C.Deocaris, Kazuhiko Yamasaki, Kazunari Taira, Sunil C. Kaul, RenuWadhwa.

27. Proteasomal Oscillation During Mild Heat Shock in AgingHuman Skin Fibroblasts. David Christian Kraft, Custer C. Deocaris,Suresh I.S. Rattan.

28. Apoptosis and Necrosis in Senescent Human Fibroblasts.Susumu Ohshima.

29. Aging of Murine Mesenchymal Stem Cells. Christine Fehrer,Gerhard Laschober, Günter Lepperdinger.

30. Prevention of Accelerated Cell Ageing in Werner Syndrome.Terence Davis, Michèle F. Haughton, Christopher J. Jones,David Kipling.

31. Oxidative Stress induces intralysosomal Accumulation ofAlzheimer Amyloid ƒ-Protein in Cultured Neuroblastoma Cells.Lin Zheng, Karin Roberg, Fredrik Jerhammar, Jan Marcusson, AlexeiTerman.

32. The Genetics of Human Longevity. Miriam Capri, StefanoSalvioli, Federica Sevini, Silvana Valensin, Laura Celani, DanielaMonti, Graham Pawelec, Giovanna De Benedictis, ClaudioFranceschi.

33. Search for Genetic Factors Associated with Susceptibility toMultiple Sclerosis. Giusi Irma forte, Paolo Ragonese, GiuseppeSalemi, Letizia Scola, Giuseppina Candore, Marco D'amelio, antonioCrivello, Norma Di Benedetto, Domenico Nuzzo, antonio Giacalone,Domenico Lio, Calogero Caruso.

34. Opposite Role of Pro-inflammatory Alleles in AcuteMyocardial infarction and Longevity: Results of Studies Performedin the Sicilian Population. Giuseppina Candore, Carmela RitaBalistreri, Maria Paola Grimaldi, Florinda Listì, Sonya Vasto,Marco Caruso, Gregorio Caimi, Enrico Hoffmann, GiuseppinaColonna-Romano, Domenico Lio, Giuseppe Paolisso, ClaudioFranceschi, Calogero Caruso.

35. Association Between +1059g/C Crp Polymorphism and AcuteMyocardial infarction in a Cohort of Patients From Sicily: A PilotStudy. Carmela Rita Balistreri, Sonya Vasto, Florinda Listì,Grimaldi Maria Paola, Domenico Lio, Giuseppina Colonna-Romano,Marco Caruso, Gregorio Caimi, Enrico Hoffmann, Calogero Caruso,Giuseppina Candore.

36. Inflammation, Longevity and Cardiovascular Diseases: Role ofPolymorphisms of Tlr4. Giuseppina Candore, Alessandra Aquino,Carmela Rita Balistreri, Matteo Bulati, Daniele Di Carlo, MariaPaola Grimaldi, Florinda Listì, Valentina Orlando, SonyaVasto, Marco Caruso, Giuseppina Colonna-Romano, Domenico Lio,Calogero Caruso.

37. Frequency of Polymorphisms of Signal Peptide of Tgf-Â1and –1082g/A Snp At the Promoter Region of Il-10 Gene in aGroup of Patients with Carotid Stenosis. antonio Crivello, antonioGiacalone, Letizia Scola, Giusi Irma forte, Domenico Nuzzo,Robertina Giacconi, Catia Cipriano, Giuseppina Candore, EugenioMocchegiani, Giuseppina Colonna Romano, Domenico Lio, CalogeroCaruso.

38. Reduced Expression Levels of the Senescence BiomarkerClusterin/Apolipoprotein J in Lymphocytes from HealthyCentenarians. Ioannis P. Trougakos, Chariklia Petropoulou, ClaudioFranceschi, Efstathios S. Gonos.

39. Heat Shock Protein 70 Genes and Human Longevity. A View FromDenmark. Ripudaman Singh, Steen Kølvraa, Peter Bross, KaareChristensen, Niels Gregersen, Qihua Tan, Uffe Birk Jensen, HansEiberg, Suresh I. S. Rattan.

40. Possible Associations Between Successful Ageing andPolymorphic Markers in Werner Gene Region Mari Sild, Cemile Koca,Mette H. Bendixen, Henrik Frederiksen, Matt Mcgue, SteenKølvraa, Kaare Christensen, Bjørn Nexø.

41. The Pattern of Chromosome-Specific Variations in TelomereLength in Humans Show Signs of Heritability and is MaintainedThrough Life. J. Graakjaer, J.A. Londono-Vallejo, K. Christensen,Steen Kølvraa.

42. Identification of Genes involved in Healthy Aging andLongevity. Jens Weibel, Morten Dræby, Peter Kristensen.

43. Prevention and Treatment of Skin Aging. Jerry L. Mccullough,Kristen M. Kelly.

44. Kinetin-induced Differentiation of Normal HumanKeratinocytes Undergoing Aging in vitro. Ulrich Berge, PeterKristensen, Suresh I.S. Rattan.

45. Epidermal and Dermal Characteristics in Skin EquivalentAfter Systemic and Topical Application of Skin Care ingredients:Jana Vicanova, Charbel Bouez, Sophie Lacroix, Lars Lindmark, OdileDamour.

46. Map Kinases and Heat Shock-induced Hormesis in HumanFibroblasts During Serial Passaging in vitro. Elise R. Nielsen,Yvonne E.G. Eskildsen-Helmond, Suresh I.S. Rattan.

47. The Roles of Satellite Cells and Hematopoietic Stem Cells inImpaired Regeneration of Skeletal Muscle in Old Rats. ShuichiMachida, Mitsuo Narusawa.

48. Age-Related Effects of Dexamethasone Administration inAdrenal Zona Reticularis. Henrique Almeida, Liliana Matos, JorgeFerreira, Delminda Neves.

49. Does Chronic Glycolysis Accelerate Ageing? Could thisExplain how Dietary Restriction Works?. Alan R. Hipkiss.

50. Would Carnosine or a Carnivorous Diet Help Suppress Ageingand Associated Pathologies?. Alan R. Hipkiss.

51. The Necessity of Having a Proper Dose of (-)Deprenyl (D) toProlong the Life Spans of Rats Explains Discrepancies AmongDifferent Studies in the Past. Kenichi Kitani, Setsuko Kanai, KyokoMiyasaka, Maria Cristina Carrillo, Gwen O. Ivy.

52. The Processing, Lysis and Elimination of Brain Lipopigmentsin Rejuvenation therapies Sorin Riga, Dan Riga, Francisc Schneider,Florin Halalau.

53. Effect of Dietary Restriction on Learning and MemoryImpairments and Histological Alterations of Brainstem inSenescence-Accelerated Mouse (Sam) P8 Strain Ryoya Takahashi,Yukari Komiya, Sataro Goto.

54. Curcumin’s Biphasic Hormetic Response on ProteasomeActivity and Heat Shock Protein Synthesis in Human Keratinocytes.Rehab E. Ali, Suresh I.S. Rattan.

55. Nutraceutical Supplementation: Effect of a Fermented PapayaPreparation on Redox Status and DNA Damage in Healthy Elderlyindividuals and Relationship with Gstm1 Genotype. A Randomized,Placebo-Controlled, Cross-Over Study Francesco Marotta, M Weksler,Y Naito, C Yoshida, M Yoshioka, P Marandola.

56. Redox Status Impairment in Liver and Kidney ofPrematurely-Senescent Mice: Effectiveness of Dts PhytotherapeuticCompound. Francesco Marotta, M Harada, Sk ono-Nita, E Minelli, PMarandola.

57. A Dietary Supplement Improves an Experimentalinfluenza-Model in Old Mice Francesco Marotta, J Cervi, C Bater, KMasulair, E Minelli, M Harada, P Marandola.

58. Pre-incubation with the Proteasome inhibitor Mg132 EnhancesProteasome Activity Via the Nrf2 Transcription Factor in AgingHuman Skin Fibroblasts David Christian Kraft, Custer C. Deocaris,Renu Wadhwa, Suresh I.S. Rattan.

59. Exercise and Hormesis: Activation of Cellular antioxidantSignaling Pathway. Li Li Ji, Maria-Carmen Gomez-Cabrera, JoseVina.

60. Stem Cells - Potential therapy for Age-Related Diseases.Moustapha Kassem.

61. Heat Shock-induced Enhancement of OsteoblasticDifferentiation of Htert Immortalized Mesenchymal Stem Cells. RuneNørgaard, Moustapha Kassem, Suresh I.S. Rattan.

62. Selective Ppar Agonists for the Treatment of Diabetes Type2. Jan Nehlin, John P. Mogensen, ingrid Petterson, Lone Jeppesen,Jan Fleckner, Erik M. Wulff, Per Sauerberg.

63. Alzheimers Disease Pathogenesis: Role of Aging Denham.Dennis Harman.

64. RNA Regulation in Mammals. Maciej Szymanski, JanBarciszewski.

65. Quantum Dot-Based Protein Imaging and FunctionalSignificance of Two Mitochondrial Chaperones in Cellular Senescenceand Carcinogenesis. Zeenia Kaul, Kamaljit Kaur, Sunil C. Kaul, RenuWadhwa.

66. Phage Displayed antibodies for the Detection of GlycatedProteasome in Aging Cells. Regina Gonzalez-Dosal, Morten DræbySørensen, Brian F.C. Clark, Suresh I. S. Rattan, PeterKristensen.

67. Techniques Used in Studies of Age-Related DNA MethylationChanges. Tomasz K Wojdacz, Lise Lotte Hansen.

68. Geroprotection by Glycerol: insights to its Mechanisms andClinical Potentials. Custer C. Deocaris, Bhupal G. Shrestha, DavidC. Kraft, Kazuhiko Yamasaki, Sunil C. Kaul, Kazunari Taira, SureshI. S. Rattan, Renu Wadhwa.

69. Age-Dependent Effects of in Vitro Radiofrequency Exposure(Mobile Phone) on Cd95+ T Helper Human Lymphocytes. Miriam Capri,Stefano Salvioli, Serena Altilia, Federica Sevini, DanielRemondini, Pietro Mesirca, Ferdinando Bersani, Daniela Monti,Claudio Franceschi.

70. Severe Acute Respiratory Syndrome and Phage Display. MortenDræby Sørensen, Brian Sørensen, Connie JenningMelchjorsen, Jens Weibel, Jing Wang, Chen Wie Jun, Yang Huanming,Peter Kristensen

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