Understanding the Process of Aging: The Roles of Mitochondria, Free Radicals, and Antioxidants / Edition 1

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Overview

This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area.
Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants!
Featuring the research of over 55 experts in the area, Understanding the Process of Aging

  • covers the functions of nitric oxide and peroxynitrite in mitochondria
  • integrates several views on the role of mitochondria in the development of apoptosis
  • gives a quantitative analysis of mutations of mitochondrial DNA during human aging
  • highlights mitochondrial free radical production
  • introduces new roles of ubiquinone in mitochondrial functions
  • offers new antioxidant-based complementary therapeutic strategies
  • details aspects of intact cells and whole organisms in health and disease
  • and more!
    Featuring over 1800 references, tables, drawings, and photographs, Understanding the Process of Aging benefits nutritionists and dieticians, geriatricians, cell and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: A long standing hypothesis regarding aging (however defined) relates to cumulative oxidative damage caused to cells and extracellular matrix components. The focus in this volume is on the possible relationship of mitochondria and their components to this process.
Purpose: The purpose is to provide an examination of a current hypothesis of the role of mitochondria in aging.
Audience: This book is intended for those scientists working on the molecular aspects of aging.
Features: Topics include oxygen radical production, nitric oxide, superoxide, ubiquinone, relationship to apoptosis, and iron. Damage to mitochondrial DNA is also considered. In several of the chapters the editors provide circumstantial but not hard evidence, a common problem in this field. The individual contributions are well prepared and each has a suitable bibliography.
Assessment: Given the nature of the problem and the difficulty in doing molecular studies in this area, this up-to-date recapitulation will be of value to those interested in exploring the yin-yang of oxygen as both necessity and threat.
Eugene A. Davidson
A long standing hypothesis regarding aging (however defined) relates to cumulative oxidative damage caused to cells and extracellular matrix components. The focus in this volume is on the possible relationship of mitochondria and their components to this process. The purpose is to provide an examination of a current hypothesis of the role of mitochondria in aging. This book is intended for those scientists working on the molecular aspects of aging. Topics include oxygen radical production, nitric oxide, superoxide, ubiquinone, relationship to apoptosis, and iron. Damage to mitochondrial DNA is also considered. In several of the chapters the editors provide circumstantial but not hard evidence, a common problem in this field. The individual contributions are well prepared and each has a suitable bibliography. Given the nature of the problem and the difficulty in doing molecular studies in this area, this up-to-date recapitulation will be of value to those interested in exploring the yin-yang of oxygen as both necessity and threat.

2 Stars from Doody
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Product Details

  • ISBN-13: 9780824717230
  • Publisher: Taylor & Francis
  • Publication date: 1/28/1999
  • Series: Oxidative Stress and Disease Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 384
  • Product dimensions: 6.25 (w) x 9.25 (h) x 1.25 (d)

Table of Contents

The Mitochondrial Production of Oxygen Radicals and Cellular Aging, Alberto Boveris, Lidia E. Costa, and Enrique Cadenas
Walking a Tightrope: The Balance Between Mitochondrial Generation and Scavenging of Superoxide Anion, David M. Guidot and Joe M. McCord
The Biochemistry of Nitric Oxide and Peroxynitrite: Implications for Mitochondrial Function, Rakesh P. Patel, Trudy Cornwell, and Victor M. Darley-Usmar
Oxygen-Dependent Regulation of Biological Functions by Nitric Oxide, Kozo Utsumi, Yoshiki Takehara, Yoko Inai, Munehisa Yabuki, Tomoko Kanno, Manabu Nishikawa, Eisuke F. Sato, and Masayasu Inoue
Production of Reactive Oxygen Species in Mitochondria and Age-Associated Pathophysiology: A Reality Check, Henry Jay Forman and Angelo Azzi
Functional Roles of Ubiquinone, Jeffery R. Schultz and Catherine Freitag Clarke
Mitochondrial Generation of Reactive Oxygen Species and Oxidative Damage During Aging: Roles of Coenzyme Q and Tocopherol, Rajindar S. Sohal, Achim Lass, Liang-Jun Yan, and Linda K. Kwong
Mitochondria and Aging: The Mouse's Tale, Steve Esworthy
Mitochondria and Apoptosis, Bernard M. Babior, Roberta A. Gottlieb, and Christoph Richter
Role of Mitochondria in Oxidative Stress Associated with Aging and Apoptosis: Studies in Intact Cells, Juan Sastre, Federico V. Pallardó, José García de la Asunción, Miguel A. Asensi, Juan M. Esteve, and José Viña-Ribes
The Role of Iron and Mitochondria in Aging, Patrick B. Walter, Kenneth B. Beckman, and Bruce N. Ames
The Mitochondrial-Lysosomal Axis Theory of Cellular Aging, Ulf T. Brunk and Alexei Terman
Quantitative Analysis of Mutations of Mitochondrial DNA During Human Aging, Jörg Napiwotzki, Annette Reith, Andreas Becker, Sandra Leist, and Bernhard Kadenbach
Oxidative Damage and Fragility of Mitochondrial DNA, Takayuki Ozawa
Mitochondria in Cellular Aging and Degeneration, Gino A. Cortopassi and Alice Wong
Mitochondrial Alteration in Aging and Inflammation: A Possible Site of Action of Nitrone-Based Free Radical Traps, Kenneth Hensley, Lindsay Maidt, C. A. Stewart, Quentin N. Pye, K. A. Robinson, and Robert A. Floyd
Muscle Mitochondrial Transmembrane Processes in Mitochondriocytopathies, Marjan Huizing, J.M.F. Trijbels, J.A.M. Smeitink, L.P. van den Heuvel, Fernando Palmieri, and Wim Ruitenbeek

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