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Doody's Review ServiceReviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: A long standing hypothesis regarding aging (however defined) relates to cumulative oxidative damage caused to cells and extracellular matrix components. The focus in this volume is on the possible relationship of mitochondria and their components to this process.
Purpose: The purpose is to provide an examination of a current hypothesis of the role of mitochondria in aging.
Audience: This book is intended for those scientists working on the molecular aspects of aging.
Features: Topics include oxygen radical production, nitric oxide, superoxide, ubiquinone, relationship to apoptosis, and iron. Damage to mitochondrial DNA is also considered. In several of the chapters the editors provide circumstantial but not hard evidence, a common problem in this field. The individual contributions are well prepared and each has a suitable bibliography.
Assessment: Given the nature of the problem and the difficulty in doing molecular studies in this area, this up-to-date recapitulation will be of value to those interested in exploring the yin-yang of oxygen as both necessity and threat.