Unraveling Lipid Metabolism

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Overview

Reviewing current studies and previously unpublished research from leading laboratories around the world, Unraveling Lipid Metabolism with Microarrays demonstrates the use of microarrays and transcriptomic approaches to clarify the biological function of lipids. With contributions from world-class researchers, the book focuses on the use of microarrays to study and understand lipid metabolism.

With coverage that spans the technologies of genomics, transriptomics, and meatabolomics, the text contains reviews of published work, provides a fresh look at new data, and presents previously unpublished work. It explores the role of fatty acids in gene expression and the various effects lipids have on the cell cycle, cholesterol metabolism, and insulin secretion. Taking a proteomic approach to looking at lipids, the book covers a wide variety of subjects, all linked to the study of lipid metabolism.

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Product Details

  • ISBN-13: 9780824758110
  • Publisher: CRC Press
  • Publication date: 11/23/2004
  • Pages: 472
  • Product dimensions: 6.00 (w) x 9.10 (h) x 1.20 (d)

Table of Contents

DATA ANALYSIS AND STATISTICAL INTERPRETATION IN MICROARRAY EXPERIMENTS
Statistical Design and Data Analysis for Microarray Experiments, D.R. Golstein and M. Delorenzi

EXPLORING FATTY ACID AND CHOLESTEROL METABOLISM USING MICROARRAYS
Dietary Effects of Arachidonate-Rich Fungal Oil and Fish Oil on Murine Hepatic Gene Expression: Focus on Newly Described LC-PUFA Regulated Genes, A. Berger and M.A. Roberts
Dietary Effects of Arachidonate-Rich Fungal Oil and Fish Oil on Murine Hippocampal Gene Expression: Links to Transcription Factors and Behavior, A. Berger and M.A. Roberts
Exploring the Effects of Polyunsaturated Fatty Acids on Gene Expression in Human Hepatocyte (HepG2 Cells) Using DNA Chip, Y. Fujuwara and A. Masumoto
Neurological Effects of Dietary N-3 Fatty Acids in Rat Brain, T. Farkas, K. Kitajka. G. Barcelo-Coblijn, and L.G. Puskas
Anterior and Posterior Cerebral Gene Expression in a Rat Model of Reduced Brain Docosahexaenoic Acid During Development, J.B. Gaines, N.E.J. Berman, S.E. Carlson
A Genomic Approach to Studying Leptin Signaling in a Hypothalmic Cell Line, W. Kaszubska, P. Hessler, and P.E. Kroeger
Characterizing Cholesterol Metabolism in Atherosclerosis Susceptible and Resistant Mouse Models Using DNA Microarrays, L. Vergnes, J. Phan, and K. Reue
Microarray Analysis of Lipid Metabolism in Drug Abuse, Neurological and Psychiatric Disorders, E. Lehrmann, C.-T. Lee, J. Chen, K.G. Becker, and W.J. Freed

EXPLORING THE ROLES OF PPARS, HNFS, AND SREBPS USING MICROARRAYS
Microarray Analyses of SREBP-1 Target Genes, N. Yahagi and H. Shimano
Understanding the Coordinated Effects of PPARs on Lipid Metabolism Using Microarrays, S. Kersten, P. Escher, S. Tafuri, and W. Wahli
Microarray Analysis of Changes Induced by Peroxisome Proliferator-Activated Receptor a-Agonists in the Expression of Genes Involved in Lipid Metabolism, K. Yamazaki, T. Hihara, H. Yoshitomi, J. Kuromitsu, and I. Tanaka

EXPLORING LIPIDS AND CARCINOGENESIS USING MICROARRAYS
How Dietary Long Chain Fatty Acids Induce Gene Signals Involved in Carcinogenesis, P. Anderle, P. Farmer, A. Berger, and M.A. Roberts
Omega-3 Polyunsaturated Fatty Acid Against Colon Cancer: DNA Microarray Analysis of Gene-Nutrient Interactions, B.A. Narayanan, N.K. Narayanan, and B.S. Reddy
Ellagic Acid Modulate Lipid Metabolism in Prostate Cancer: Gene-Nutrient Interactions, B.A. Narayanan, N.K. Narayanan, O. Geoffrey, and D.W. Nixon

EXPLORING HOW LIPIDS AFFECT INSULIN SECRETION USING MICROARRAYS
Changes of Gene Expression in INS-1 Cells: The Implication of Pamitate in Lipotoxicity, J.Xiao, M. Kruhoffer, P. Bendix Jeppesen, A. Reziwanggu, T. Orntoft, and K. Hermansen
Use of Microarrays to Investigate the Transcriptional Effects of Protein Tyrosine Phosphatase IB (PTP1B): Implications for Diabetes and Obesity, C.M. Rondinone and J.F. Waring

OTHER "OMIC" TECHNIQUES FOR UNRAVELLING LIPID METABOLISM
Metabonomics as a Tool for Understanding Lipid Metabolism, D.J. Grainger, D.E. Mosedale, E. Holmes, and J.K. Nicholson
Zebrafish Model of Lipid Metabolism for Drug Discover, A.L. Rubinstein, S.-Y. Ho, and S.A. Farber

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