The Use of Restricted Significance Tests in Clinical Trials / Edition 1

The Use of Restricted Significance Tests in Clinical Trials / Edition 1

by David S. Salsburg
     
 

This thought-provoking book discusses the use of statistics in randomized clinical trials. Its aim is two-fold: firstly, it presents a clear account of the design and analysis of experiments in this setting which stresses the foundational issues involved. Secondly, the book seeks to develop the specific tools of analysis which can be derived from Neyman's model of… See more details below

Overview

This thought-provoking book discusses the use of statistics in randomized clinical trials. Its aim is two-fold: firstly, it presents a clear account of the design and analysis of experiments in this setting which stresses the foundational issues involved. Secondly, the book seeks to develop the specific tools of analysis which can be derived from Neyman's model of restricted tests. The book is based on the author's many years of experience of clinical trials. Throughout, examples are used from a variety of types of study. As a result, all statisticians and research scientists who work on clinical trials will find this presentation clear and accessible, and very relevant to their own research interests.

Product Details

ISBN-13:
9780387977980
Publisher:
Springer New York
Publication date:
08/06/1992
Series:
Statistics for Biology and Health Series
Edition description:
1992
Pages:
173
Product dimensions:
9.21(w) x 6.14(h) x 0.50(d)

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Meet the Author

Table of Contents

Preface
Pt. 1Philosophical and Scientific Problems when Applying Statistical Methods to Clinical Data
Ch. 1The Randomized Controlled Clinical Trial3
Ch. 2Probability Models and Clinical Medicine10
Ch. 3Significance Tests Versus Hypothesis Tests22
Ch. 4Neyman's Insights30
Ch. 5Reconciling Fisher and Neyman39
Pt. 2Techniques for Applying Restricted Tests to Data from Randomized Controlled Clinical Trials
Ch. 6Continuous Measures Taken over Time49
Ch. 7Combining Data Across Measures60
Ch. 8Counts of Events78
Ch. 9Permutation Tests and Resampling Techniques89
Ch. 10Neyman's Restricted Chi Square Tests97
Ch. 11Miscellaneous Methods for Increasing Power104
Ch. 12Bayesian Estimation115
Ch. 13An Example of the Type of Analysis Suggested in This Book126
References161
Index171

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